6-Chloropurine
- CAS No.
- 87-42-3
- Chemical Name:
- 6-Chloropurine
- Synonyms
- 6-CHLORO-9H-PURINE;ClP;6-CHLORO-7H-PURINE;6-CP;6-chloro-5H-purine;x47;X 47;nsc744;sk6048;NSC 744
- CBNumber:
- CB1726169
- Molecular Formula:
- C5H3ClN4
- Molecular Weight:
- 154.56
- MOL File:
- 87-42-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/8 13:48:25
| Melting point | >300 °C (dec.) (lit.) |
|---|---|
| Boiling point | 254.17°C (rough estimate) |
| Density | 1.4649 (rough estimate) |
| refractive index | 1.8430 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | 5 g/L |
| pka | 7.47±0.20(Predicted) |
| form | crystalline |
| color | yellow-orange |
| Water Solubility | 5 g/L |
| Merck | 14,2161 |
| BRN | 5774 |
| InChIKey | ZKBQDFAWXLTYKS-UHFFFAOYSA-N |
| CAS DataBase Reference | 87-42-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 6-Chloropurine(87-42-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312a-P330-P501a-P264-P270-P301+P312+P330-P501 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UO7520000 | |||||||||
| F | 10-23 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29335990 | |||||||||
| Toxicity | LD50 oral in mouse: 720mg/kg | |||||||||
| NFPA 704 |
|
6-Chloropurine price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 511617 | 6-Chloropurine 99% | 87-42-3 | 5G | ₹5531.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 161179 | 6-Chloropurine ≥99% | 87-42-3 | 5G | ₹5531.58 | 2022-06-14 | Buy |
| ALFA India | ALF-A11202-14 | 6-Chloropurine, 99% | 87-42-3 | 25g | ₹19139 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C0278 | 6-Chloropurine | 87-42-3 | 5G | ₹3900 | 2022-05-26 | Buy |
| ALFA India | ALF-A11202-06 | 6-Chloropurine, 99% | 87-42-3 | 5g | ₹4848 | 2022-05-26 | Buy |
6-Chloropurine Chemical Properties,Uses,Production
Chemical Properties
It is a pale yellow crystal with relatively stable chemical properties that do not cause decomposition at room temperature. Its structure includes nitrogen heterocycles, which give rise to remarkable alkalinity and the formation of volatile acid salts. It is soluble in dimethyl sulfoxide, but has only slight solubility in water.
Uses
6-Chloropurine is used in the preparation of 9-alkylpurines through alkylation with various substituted alkyl halides in dimethyl sulfoxide. It is also used to prepare 6-succinoaminopurine.
Definition
ChEBI: 6-Chloro-1H-purine is a member of purines. It is metabolized to form 6-mercaptopurine and has been used as an antineoplastic.
Preparation
6-chloropurine is synthesized by reacting hypoxanthine with phosphoryl chloride in the presence of an unreactive base such as dimethyl aniline. It may likewise be formed by heating hypoxanthine under pressure with phosphoryl chloride as well as with a reagent prepared by adding water, preferably about by volume, to dry phosphoryl chloride.
US2832781A
General Description
The acid-catalyzed reaction of 6-chloropurine with 3,4-di-O-acetyl-D-xylal has been investigated.
Purification Methods
6-Chloropurine crystallises from water. The UV in water at pH 1 has 264nm (log 3.94). [Beilstein 26 III/IV 1742.]
6-Chloropurine Preparation Products And Raw materials
Raw materials
Preparation Products
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| Aarti Industries Limited (AIL) | +91-84596144931 +91-9920899935 | Maharashtra, India | 235 | 58 | Inquiry |
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| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Aarti Industries Limited (AIL) | 58 |
| ALS INDIA LIFE SCIENCES | 58 |
| S.R.LABORATORIES | 30 |
| CHEMSWORTH | 30 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Triveni chemicals | 58 |
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