6-Chloroguanine
- CAS No.
- 10310-21-1
- Chemical Name:
- 6-Chloroguanine
- Synonyms
- 2-AMINO-6-CHLOROPURINE;6-Chloro-7H-purin-2-amine;2-amino-6-chloro-purin;6-CHLORO-2-AMINOPURINE;9H-PURIN-2-AMINE, 6-CHLORO-;2-AMINO-6-CHLOROPURINE (2A6ClP);AURORA KA-689;6-CHLOROGUANINE;TIMTEC-BB SBB003863;2-AMino-6-chlorpurin
- CBNumber:
- CB4143631
- Molecular Formula:
- C5H4ClN5
- Molecular Weight:
- 169.57
- MOL File:
- 10310-21-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/29 18:03:56
| Melting point | >300 °C (lit.) |
|---|---|
| Boiling point | 279.76°C (rough estimate) |
| Density | 1.4937 (rough estimate) |
| refractive index | 1.6110 (estimate) |
| storage temp. | 2-8°C |
| solubility | Solubility in 1mol/L NaOH |
| form | Powder |
| pka | 6.65±0.20(Predicted) |
| color | White to yellow |
| Water Solubility | 1.7 g/L (20 ºC) |
| BRN | 9626 |
| InChI | InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11) |
| InChIKey | RYYIULNRIVUMTQ-UHFFFAOYSA-N |
| SMILES | N1C2C(=NC(N)=NC=2Cl)NC=1 |
| CAS DataBase Reference | 10310-21-1(CAS DataBase Reference) |
| EPA Substance Registry System | 6-Chloro-2-aminopurine (10310-21-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P201-P202-P261-P264b-P271-P280i-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362+P364-P403+P233-P501c | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 22-24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UO7502000 | |||||||||
| F | 10 | |||||||||
| Hazard Note | Irritant/Keep Cold | |||||||||
| HazardClass | IRRITANT, KEEP COLD | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
6-Chloroguanine price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 342300 | 2-Amino-6-chloropurine 97% | 10310-21-1 | 1G | ₹4524.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2861 | Famciclovir Related Compound F pharmaceutical secondary standard, certified reference material | 10310-21-1 | 50MG | ₹44804.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 342300 | 2-Amino-6-chloropurine 97% | 10310-21-1 | 5G | ₹11355.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 109789 | 2-Amino-6-chloropurine ≥99% | 10310-21-1 | 1G | ₹3810.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 109789 | 2-Amino-6-chloropurine ≥99% | 10310-21-1 | 5G | ₹11312.13 | 2022-06-14 | Buy |
6-Chloroguanine Chemical Properties,Uses,Production
Description
2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).
Chemical Properties
white to light yellow crystal powder
Uses
2-Amino-6-chloropurine finds its uses in the enzymatic synthesis of 2?-deoxyguanosine, 9-alkyl purines and (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases.
Definition
ChEBI: 6-chloroguanine is an organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6. It is a member of 2-aminopurines and an organochlorine compound.
General Description
2-Amino-6-chloropurine is a 6-substituted purine. Tautomeric purine forms of 2-amino-6-chloropurine were investigated by vibrational spectroscopy and quantum chemical method.
Synthesis
Preparation of 2-amino-6-chloropurine:
Diacetyl guanine (8.0g, 0.034 moles), triethyimethylammonium chloride (15.45g, 0.102 moles), and triethylamine (4.74 mis, 0.034 moles) were heated together with stirring in acetonitrile (70mls) to 50°C. Phosphorus oxychioride (6.34 mis, 0.068 moles) was then added and stirring continued for 4 hours. The reaction mixture was cooled and then added to aqueous sodium hydroxide solution (20g in 300mls water). The reaction mixture was heated to 80°C for 2 hours and then the volume made up to 300 mis with water. The mixture was cooled to 25°C and the pH adjuster to 7 using 10% hydrochloric acid. The resulting slurry was stirred for fifteen minutes and the product filtered off and washed with water 30 mis and then dried at 80°C under vacuum to give a cream/off white coloured product, 2-amino-6-chioropurine 4.69 g (74.6% yield).
6-Chloroguanine Preparation Products And Raw materials
Raw materials
Preparation Products
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| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
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| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| JSK Chemicals | 58 |
| ALS INDIA LIFE SCIENCES | 58 |
| Shivam Pharma Chemicals | 58 |
| ChemOrbit International | 58 |
| CHEMSWORTH | 30 |
| Shivam Pharma - CHEM | 30 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
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