6-O-Benzylguanine
- CAS No.
- 19916-73-5
- Chemical Name:
- 6-O-Benzylguanine
- Synonyms
- 6-benzylguanine;O6-BENZYLGUANINE;O6-Benzylguanine ,98%;6-(benzyloxy)-7H-purin-2-aMine;O6-BenzyL;NSC 637037;6-O-BENZYLGUANINE;6-BENZYLOXY GUANINE;6-oxo -benzylguanine;4 6-Benzyloxyguanine
- CBNumber:
- CB9263934
- Molecular Formula:
- C12H11N5O
- Molecular Weight:
- 241.25
- MOL File:
- 19916-73-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/11 20:10:50
| Melting point | 193(dec.) |
|---|---|
| Boiling point | 459.3±55.0 °C(Predicted) |
| Density | 1.48±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | methanol: 20 mg/mL |
| form | solid |
| pka | 7.47±0.20(Predicted) |
| color | Off-White to Light Yellow |
| CAS DataBase Reference | 19916-73-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
6-O-Benzylguanine Chemical Properties,Uses,Production
Chemical Properties
Light Yellow Solid
Uses
An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents.
Biochem/physiol Actions
O6-Benzylguanine (O6BG) inhibits methylguanine methyltransferase (MGMT) by blocking the active site through benzyl group transfer. The use of O6BG with bis-chloroethylnitrosourea (BCNU) or carmustine is effective in treating solid tumors including lymphomas, melanomas and sarcoma.
6-O-Benzylguanine Preparation Products And Raw materials
Raw materials
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Global( 417)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| P. D. Polychem Pvt., Ltd. | 91-11-49064070 ext. 121 | Delhi, India | 19 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Gagri Global IT Services Pvt. Ltd. | +91-40-27170174, | Telangana, India | 1321 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
19916-73-5(6-O-Benzylguanine)Related Search:
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O(sup 6)benzylguanidine
O6-Benzylguanine ,98%
2-Amino-6-(benzyloxy)-9H-purine
6-(Benzyloxy)-1H-purin-2-amine
6-(benzyloxy)-7H-purin-2-aMine
6-(PhenylMethoxy)-9H-purin-2-aMine
NSC 637037
6-benzylguanine
6-oxo -benzylguanine
6-O-Benzylguanine(O6BG)
9H-Purin-2-amine,6-(phenylmethoxy)-
6-phenylmethoxy-7H-purin-2-amine
O6-BENZYLGUANINE
2-Amino-6-(benzyloxy)purine
2-amino-6-(phenylmethoxy)-9h-purine
Ganciclovir Impurity 12
6-O-BENZYLGUANINE
6-BENZYLOXY-9H-PURIN-2-AMINE
6-BENZYLOXY GUANINE
4 6-Benzyloxyguanine
6-BENZYLOXY GUANINE2-AMINO-6-BENZYLOXYPURINE
O6-BenzyL
2-((2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)propane-1,3-diyl dibenzoate
"2-Amino-6-(benzyloxy)purine, 2-Amino-6-(phenylmethoxy)-9H-purine"
19916-73-5
9916-73-5
Apoptosis and Cell Cycle
DNA Repair Regulators
DNA metabolism
BioChemical
Cell Signaling and Neuroscience
Cell Biology
Alkylguanine-DNA alkyltransferase, mammalian DNA repair proteinApoptosis and Cell Cycle
DNA Repair Regulators
A to
DNA metabolism
Enzyme Inhibitors by Enzyme
Nucleotides and Nucleosides
Bases & Related Reagents
Nucleotides