ChemicalBook > Product Catalog >Organic Chemistry >Nitrogen Compounds >4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

CAS No.: 479633-63-1

Chemical Name:: 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

Synonyms: Tofacitinib Impurity 20;Tofacitinib-9;Tofacitinib imurity;Tofatinib Impurity 1;Tofatinib Impurity P;Tofacitinib Impurity R;Tofacitinib Impurity 53;4-Chloro-7-tosyl-7H-pyrro...;4-Chloro-7-tosyl-7H-pyrrolo[2;Azilsartan medoxomil impurity345

CBNumber:: CB32452480

Molecular Formula:: C13H10ClN3O2S

Molecular Weight:: 307.76

MOL File:: 479633-63-1.mol

Modify Date:: 2024/11/14 14:09:35

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4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Properties

Melting point	145.0 to 149.0 °C
Boiling point	505.3±60.0 °C(Predicted)
Density	1.49
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly)
form	powder to crystal
pka	1.73±0.30(Predicted)
color	White to Orange to Green
InChI	InChI=1S/C13H10ClN3O2S/c1-9-2-4-10(5-3-9)20(18,19)17-7-6-11-12(14)15-8-16-13(11)17/h2-8H,1H3
InChIKey	BTOJSYRZQZOMOK-UHFFFAOYSA-N
SMILES	C1=NC(Cl)=C2C=CN(S(C3=CC=C(C)C=C3)(=O)=O)C2=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes	Xn
Risk Statements	22
HazardClass	IRRITANT
HS Code	2933599590

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	ADE000077	4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine AldrichCPR	479633-63-1	1G	₹68706.28	2022-06-14	Buy
TCI Chemicals (India)	C3036	4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine	479633-63-1	1G	₹8000	2022-05-26	Buy
TCI Chemicals (India)	C3036	4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine	479633-63-1	5G	₹18200	2022-05-26	Buy

Product number	Packaging	Price	Buy
ADE000077	1G	₹68706.28	Buy
C3036	1G	₹8000	Buy
C3036	5G	₹18200	Buy

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Uses,Production

Uses

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine is a reagent in the synthesis of (+)-tofacitinib, a selective Janus kinase 3 inhibitor (JAK3) and an immunosuppressant drug.

Synthesis

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine (2kg, 12.96mol) and dichloromethane (40L) were added to the reaction flask at room temperature, stirred and dissolved. Triethylamine (3.88 kg, 38.4 mol) and 4-dimethylamino pyridine (157.6 g, 1.28 mol) were added in that order, and after stirring and dissolved, p-toluenesulfonyl chloride (2.6 kg, 13.6 mol) was added dropwise at 0 °C. The chloromethane (30 L) solution was added dropwise, and the mixture was stirred at room temperature for 30 min. After the TLC was applied, the mixture was washed with water (16L×3). 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (3.9 kg, yield 97.7%) was obtained after drying under reduced pressure.

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Tosyl chloride 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

Preparation Products

4-IODO-7-[(4-METHYLPHENYL)SULFONYL]-7H-PYRROLO[2,3-D]PYRIMIDINE

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Suppliers

Global( 405)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
EPOCH LABS	+91-7702174901 +91-9515109812	Hyderabad, India	68	58	Inquiry
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Shreyasvi Lifesciences Pvt Ltd	+919848346660	Telangana, India	66	58	Inquiry
PSN Medicare Private Limited	+91-9030090313 +91-7702388996	Telangana, India	82	58	Inquiry
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A.J Chemicals	91-9810153283	New Delhi, India	6100	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6739	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6768	58	Inquiry

Supplier	Advantage
EPOCH LABS	58
VGS SYNTHESIS PRIVATE LIMITED	58
Varanous Labs Pvt Ltd	58
Shreyasvi Lifesciences Pvt Ltd	58
PSN Medicare Private Limited	58
Opulent Pharma	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
TCI Chemicals (India) Pvt. Ltd.	58

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Spectrum

4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE(479633-63-1)¹HNMR

479633-63-1(4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine)Related Search:

N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride DEAZAPURINE 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

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2-Thiouracil 2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE 4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine Pyrrolo[2,3-d]pyrimidin-4-ol N4-Benzoylcytosine

4-Aminopyrazolo[3,4-d]pyrimidine 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine Tofacitinib Impurity T

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Tofacitinib Impurity R 4-Chloro-7-(p-tolylsulfonyl)pyrrolo[2,3-d]pyrimidine 4-CHLORO-7-[(4-METHYLPHENYL)SULFONYL]-7H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE 4-Chloro-7-tosyl-7H-pyrro... 4-Chloro-7-[(4-methylbenzene)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine 4-Chloro-7-p-toluenesulphonyl-7H-pyrrolo[2,3-d]pyrimidine 7H-Pyrrolo[2,3-D]pyriMidine,4-chloro-7-[(4-Methylphenyl)sulfonyl]- 4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine 4-Chloro-7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine 4-Chloro-7-tosyl-7H-pyrrolo[2 4-chloro-7-(4-methylphenyl)sulfonylpyrrolo[2,3-d]pyrimidine Tofacitinib-9 4-Chloro-7-[(4-methylbenzene)sulfonyl]pyrrolo[2,3-d]pyrimidine Tofacitinib imurity 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-2-yl) amino)piperidin-1-yl)-3-oxopropanenitrile Tofacitinib Impurity 53 4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine > 4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrim... Azilsartan medoxomil impurity345 Tofacitinib Impurity 20 Tofatinib Impurity 1 Tofatinib Impurity P 479633-63-1 Heterocycle-Pyrimidine series ADVANCED INT.