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4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘

4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘 구조식 이미지

카스 번호:: 479633-63-1

한글명:: 4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘

동의어(한글):: 4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘

상품명:: 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

동의어(영문):: Tofacitinib Impurity 20;Tofacitinib-9;Tofacitinib imurity;Tofatinib Impurity 1;Tofatinib Impurity P;Tofacitinib Impurity R;Tofacitinib Impurity 53;4-Chloro-7-tosyl-7H-pyrro...;4-Chloro-7-tosyl-7H-pyrrolo[2;Azilsartan medoxomil impurity345

CBNumber:: CB32452480

분자식:: C13H10ClN3O2S

포뮬러 무게:: 307.76

MOL 파일:: 479633-63-1.mol

속성

안전

용도

공급 업체 392

4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘 속성

녹는점: 145.0 to 149.0 °C

끓는 점: 505.3±60.0 °C(Predicted)

밀도: 1.49

저장 조건: Keep in dark place,Sealed in dry,Room Temperature

용해도: 클로로포름 (약간 용해됨), DMSO (약간 용해됨)

물리적 상태: powder to crystal

산도 계수 (pKa): 1.73±0.30(Predicted)

색상: White to Orange to Green

InChI: InChI=1S/C13H10ClN3O2S/c1-9-2-4-10(5-3-9)20(18,19)17-7-6-11-12(14)15-8-16-13(11)17/h2-8H,1H3

InChIKey: BTOJSYRZQZOMOK-UHFFFAOYSA-N

SMILES: C1=NC(Cl)=C2C=CN(S(C3=CC=C(C)C=C3)(=O)=O)C2=N1

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xn
위험 카페고리 넘버	22
위험 등급	IRRITANT
HS 번호	2933599590

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고		P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고		P264, P280, P305+P351+P338,P337+P313P

예방조치문구:

P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352	피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P332+P313	피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P337+P313	눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.

4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘 C화학적 특성, 용도, 생산

용도

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine is a reagent in the synthesis of (+)-tofacitinib, a selective Janus kinase 3 inhibitor (JAK3) and an immunosuppressant drug.

Synthesis

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine (2kg, 12.96mol) and dichloromethane (40L) were added to the reaction flask at room temperature, stirred and dissolved. Triethylamine (3.88 kg, 38.4 mol) and 4-dimethylamino pyridine (157.6 g, 1.28 mol) were added in that order, and after stirring and dissolved, p-toluenesulfonyl chloride (2.6 kg, 13.6 mol) was added dropwise at 0 °C. The chloromethane (30 L) solution was added dropwise, and the mixture was stirred at room temperature for 30 min. After the TLC was applied, the mixture was washed with water (16L×3). 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (3.9 kg, yield 97.7%) was obtained after drying under reduced pressure.

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘 준비 용품 및 원자재

원자재

파라-톨루엔설폰일 염화물 2,4-DICHLORO-7H-피롤로2,3-DPYRIMIDINE 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

준비 용품

4-IODO-7-[(4-METHYLPHENYL)SULFONYL]-7H-PYRROLO[2,3-D]PYRIMIDINE

4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘 공급 업체

글로벌( 392)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai Minbiotech Co., Ltd.	+8617315815539	sales@minbiotech.com	CHINA	129	58
Huanfu Industrial Co.，（Shanghai）Ltd.	+86-18001856580 +86-18001856580	2415195517@qq.com	China	43	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20318	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29798	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	16208	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	811	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21673	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60

4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘 관련 검색:

트리플루오로티민 2-티오우라실 Tofacitinib Impurity T N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride DEAZAPURINE 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 4-Amino-7H-pyrrolo[2,3-d]pyrimidine 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE 4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine Pyrrolo[2,3-d]pyrimidin-4-ol N4-Benzoylcytosine 4-Aminopyrazolo[3,4-d]pyrimidine 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine