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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyrimidines >Iodine pyrimidine >3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Structure
CAS No.
151266-23-8
Chemical Name:
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Synonyms
4-Amino-3-iodopyrazolo[3,4-d]pyrimidine;IbrutinibIntermediate6;7-Iodo-7-deaza-8-aza-adenine;4-AMINO-3-IODO-1H-PYRAZOLO[3;4-AMino-3-iodopyrazolo[3,4-d]pyridine;3-iodo-4-Aminopyrazolo[3,4-d]pyridine;3-iodopyrazolo[3,4-d]pyriMidin-4-aMine;3-iodo-4-AMino-1H-pyrazolo[3,4-d]pyridine;4-Amino-3-iodo-1H-pyrazolo[3,4-D]pyridine;3-iodo-2H-pyrazolo[3,4-d]pyrimidin-4-amine
CBNumber:
CB8144555
Molecular Formula:
C5H4IN5
Molecular Weight:
261.02
MOL File:
151266-23-8.mol
MSDS File:
SDS
Modify Date:
2024/7/2 9:29:29
Request For Quotation

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Properties

Boiling point 312.3±52.0 °C(Predicted)
Density 2.92±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form powder to crystal
pka 10.50±0.20(Predicted)
color White to Light yellow to Light orange
Sensitive Light Sensitive
λmax 282nm(lit.)
InChI InChI=1S/C5H4IN5/c6-3-2-4(7)8-1-9-5(2)11-10-3/h1H,(H3,7,8,9,10,11)
InChIKey HQAIUXZORKJOJY-UHFFFAOYSA-N
SMILES C1=NC(N)=C2C(I)=NNC2=N1

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xn
Risk Statements  36/37/38-22
Safety Statements  26-36/37/39-37
TSCA  N
HS Code  29335990
NFPA 704
0
2 0

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemicals (India) I0941 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine 151266-23-8 1G ₹8800 2022-05-26 Buy
TCI Chemicals (India) I0941 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine 151266-23-8 5G ₹15200 2022-05-26 Buy
Product number Packaging Price Buy
I0941 1G ₹8800 Buy
I0941 5G ₹15200 Buy

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Chemical Properties,Uses,Production

Uses

3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine acts as a reagent in the discovery and preparation of CHMFL-FLT3-122 as potent and orally available FLT3 kinase inhibitor for FLT3-ITD positive acute myeloid leukemia. Development and preparation of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.

Synthesis

A solution of 3H-pyrazolo[3,4-d]pyrimidin-4-amine (10 g, 0.074 mol) and n-iodo-succinamide (25 g, 0.111 mol) in DMF (80 mL) was heated to 80° C. overnight under an argon atmosphere. The resulting solid was filtered and rinsed with cold EtOH. The product was dried in vacuo overnight to yield 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (24 g, 100 per cent yield).

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Preparation Products And Raw materials

Raw materials

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine 4-Aminopyrazolo[3,4-d]pyrimidine 2H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI) N-Iodosuccinimide

Preparation Products

(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine 1-cyclopentyl-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine 3-(4-Phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Suppliers

Global( 356)Suppliers
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SPD CHEMICALS +91-7075800742 +91-7075800742 Hyderabad, India 214 58 Inquiry
Stereokem Pvt Ltd +91-4029706929 +91-9394224843 Telangana, India 350 58 Inquiry
Trimax bio sciences private ltd +91-8532299988 +91-8532299988 Karnataka, India 36 58 Inquiry
Aravali Pharma And Lifesciences +91-9350857917 +91-9810502945 New Delhi, India 119 58 Inquiry
Aktinos Pharma Pvt Ltd +91-4048541177 +91-4048541177 Telangana, India 42 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Aravali Pharma & Lifesciences 91--9810502945 Delhi, India 71 58 Inquiry
Supplier Advantage
SPD CHEMICALS 58
Stereokem Pvt Ltd 58
Trimax bio sciences private ltd 58
Aravali Pharma And Lifesciences 58
Aktinos Pharma Pvt Ltd 58
TCI Chemicals (India) Pvt. Ltd. 58
A.J Chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
Aravali Pharma & Lifesciences 58

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Spectrum

4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE(151266-23-8)1HNMR

151266-23-8(3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine )Related Search:

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3-iodo-2H-pyrazolo[3,4-d]pyrimidin-4-amine 3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE 4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-iodo- 4-Amino-3-iodo-1H-pyrazolo[3,4-D]pyridine 3-iodo-4-AMino-1H-pyrazolo[3,4-d]pyridine 7-Iodo-7-deaza-8-aza-adenine 3-iodopyrazolo[3,4-d]pyriMidin-4-aMine 4-AMino-3-iodopyrazolo[3,4-d]pyridine 3-iodo-4-aMino-1H-pyrazolo[3,4-d]pyriMidine 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine > 4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE ISO 9001：2015 REACH 4-AMINO-3-IODO-1H-PYRAZOLO[3 TIANFU-CHEM - 4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 3-iodo-4-Aminopyrazolo[3,4-d]pyridine 4-Amino-3-iodopyrazolo[3,4-d]pyrimidine 3-Iodo-4-amino-1H-pyrazolo[3,4-d]pyrimidine, 7-Iodo-7-deaza-8-azaadenine 3-iodo-5H-pyrazolo[3,4-d]pyrimidin-4-amine 4-AMINO-3-iodo-1H-Pyrazolo[3,4-D]Pyrimidin 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine IbrutinibIntermediate6 151266-23-8 Heterocycle-Pyridine series pharmacetical