PROFOXYDIM-LITHIUM
- CAS No.
- 139001-49-3
- Chemical Name:
- PROFOXYDIM-LITHIUM
- Synonyms
- AIK;AURA;STK7;BTAK;STK6;ARK1;AIRK1;AURKA;STK15;TETRIS
- CBNumber:
- CB4320465
- Molecular Formula:
- C24H32ClNO4S
- Molecular Weight:
- 466.03
- MOL File:
- 139001-49-3.mol
- Modify Date:
- 2023/5/4 17:34:33
| Melting point | <25 °C |
|---|---|
| Boiling point | 597.2±60.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | -70°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| pka | 4.25±0.25(Predicted) |
| color | White to Off-White |
| Stability | Hygroscopic, Unstable in Solution |
| EPA Substance Registry System | Profoxydim (139001-49-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07, GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H351-H361d |
| Precautionary statements | P201-P261-P280-P308+P313-P333+P313-P362+P364 |
| Hazard Codes | Xn |
| Risk Statements | 21/22 |
| Safety Statements | 36/37 |
| WGK Germany | 3 |
PROFOXYDIM-LITHIUM price More Price(1)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SRP5034 | GRK2, active, GST tagged human PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | 139001-49-3 | 10μG | ₹50149.8 | 2022-06-14 | Buy |
| Product number | Packaging | Price | Buy |
|---|---|---|---|
| SRP5034 | 10μG | ₹50149.8 | Buy |
PROFOXYDIM-LITHIUM Chemical Properties,Uses,Production
General Description
G-protein-coupled receptor kinase 2 (GRK2), which is officially known as adrenergic, beta, receptor kinase 1 (ADRBK1), gene codes for a 689 amino acid protein, that is of 79.573kDa. This gene has 12 catalytic region subdomains. GRK2 is expressed in the vascular endothelium, arterial smooth muscle, myocardium, kidney and in the renal proximal tubule. It is mapped to human chromosome 11q13.
Biochem/physiol Actions
G-protein-coupled receptor kinase 2 (GRK2) or ADRBK1 is a ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G protein-coupled receptors. GRK2 phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. RAF kinase inhibitor protein RKIP is a physiologic inhibitor of GRK2. After stimulation of G protein-coupled receptors, RKIP dissociates from its known target, RAF1 to associate with GRK2 and block its activity. G-protein-coupled receptor kinase 2 (GRK2) controls several intracellular mechanisms. It helps to maintain the structure and activities of the heart. Hence it participates in several cardiovascular diseases. GRK2 also modulates ion and fluid transport and eventually, blood pressure. It increases the synthesis of mitochondrial superoxide and reduces oxygen utilization and ATP synthesis. This protein serves as a major onco-modulator.
PROFOXYDIM-LITHIUM Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29897 | 58 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10318 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | China | 4088 | 58 | Inquiry |
| changzhou huayang technology co., ltd | +8615250961469 | China | 9827 | 58 | Inquiry |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8615195660023 | China | 23053 | 58 | Inquiry |
| United States Biological | 1-800-520-3011 | United States | 6106 | 58 | Inquiry |
| Crescent Chemical Co., Inc. | 631 348 0333 | United States | 4599 | 68 | Inquiry |
| 3B Scientific Corporation | 847.281.9822 | United States | 6744 | 47 | Inquiry |
| Dr. Ehrenstorfer GmbH | (0821) 90 60 80 | Germany | 5547 | 66 | Inquiry |
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