6-Methoxy-2-tetralone
- CAS No.
- 2472-22-2
- Chemical Name:
- 6-Methoxy-2-tetralone
- Synonyms
- 6-methoxy-2-Tetrlone;4-dihydro-6-Methoxy-;6-METHOXY-2-TETRALONE;6-methoxyl-2-tetralone;6-Methoxytetralin-2-one;6-Methoxy-2-tetralone>6-METHOXY-2-TETRALONE 95%;6-Methoxy-2-tetralone,98%;6-Methoxy-2-tetralone,90%;6-Methoxy-2-tetralone,tech.90%
- CBNumber:
- CB4323880
- Molecular Formula:
- C11H12O2
- Molecular Weight:
- 176.21
- MOL File:
- 2472-22-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/4 15:29:52
| Melting point | 28-35 °C |
|---|---|
| Boiling point | 114-116 °C (0.2 mmHg) |
| Density | 1.0431 (rough estimate) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| form | Crystalline Low Melting Solid |
| color | Light yellow-beige to orange |
| Sensitive | Air Sensitive |
| BRN | 513418 |
| InChI | InChI=1S/C11H12O2/c1-13-11-5-3-8-6-10(12)4-2-9(8)7-11/h3,5,7H,2,4,6H2,1H3 |
| InChIKey | RMRKDYNVZWKAFP-UHFFFAOYSA-N |
| SMILES | C1C2=C(C=C(OC)C=C2)CCC1=O |
| CAS DataBase Reference | 2472-22-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29145090 | |||||||||
| NFPA 704 |
|
6-Methoxy-2-tetralone price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 184063 | 6-Methoxy-3,4-dihydro-2(1H)-naphthalenone 95% | 2472-22-2 | 1G | ₹8183.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 184063 | 6-Methoxy-3,4-dihydro-2(1H)-naphthalenone 95% | 2472-22-2 | 5G | ₹40279.83 | 2022-06-14 | Buy |
| ALFA India | ALF-L11007-MD | 6-Methoxy-2-tetralone, tech. 90% | 2472-22-2 | 250mg | ₹4110 | 2022-05-26 | Buy |
| ALFA India | ALF-L11007-03 | 6-Methoxy-2-tetralone, tech. 90% | 2472-22-2 | 1g | ₹7917 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M1317 | 6-Methoxy-2-tetralone min. 95.0 % | 2472-22-2 | 1G | ₹7000 | 2022-05-26 | Buy |
6-Methoxy-2-tetralone Chemical Properties,Uses,Production
Description
6-methoxy-2-tetralone has been selected as the starting material for the synthesis of many steroidal compounds, including 2-aminotetalin derivatives, which exhibit antifungal activities, tetrahydro benzocycloheptane and many terpenoid compounds. 6-methoxy-2-tetralone is more expensive, difficult to synthesize, and unstable in comparison to 6-methoxy-1-tetralone[1].
Chemical Properties
light yellow-beige to orange
Uses
6-Methoxy-3,4-dihydro-2(1H)-naphthalenone was used in the synthesis of 1, 2, 3, 4-tetrahydro-2-naphthylamine derivatives.
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 9, p. 267, 1961 DOI: 10.1248/cpb.9.267
The Journal of Organic Chemistry, 26, p. 3237, 1961 DOI: 10.1021/jo01067a049
Synthesis
To a suspension of MCPBA (1.5g, 8.7mmol) in dry dichloromethane (16mL), cooled in ice, was added dihydro naphthalene (616mg, 3.8mmol) dissolved in dichloromethane (2mL). The reaction mixture was stirred overnight, filtered, diluted with dichloromethane, washed with a solution of sodium bicarbonate (5%), brine, dried, and evaporated to obtain an oil (591mg), which without purification was dissolved in ethanol (3mL) and treated with sulfuric acid (3mL, 10%) and heated under reflux for 3 hours. The reaction mixture was cooled, diluted with water, and extracted three times using chloroform. The organic extracts were washed with brine, dried, and evaporated to obtain an oil which, on purification (eluent hexane: ether 7:3), afforded 6-Methoxy-2-tetralone.
References
[1] Banerjee, A. K. et al. “A concise approach for the synthesis of 6-methoxy-2-tetralone.” 2018. 0.
6-Methoxy-2-tetralone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4535 | 58 | Inquiry |
| SynthoCascade Research Laboratories | +91-9440962500 +91-9440962500 | Telangana, India | 284 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3753 | 58 | Inquiry |
| Suven Pharmaceuticals Limited | +91-91-40-23541142 +91-4023541142 | Telangana, India | 218 | 58 | Inquiry |
| ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1878 | 58 | Inquiry |
| ASM Organics | 91-9866122393 | Andhra Pradesh, India | 1185 | 58 | Inquiry |
| Vivera Labs | 91-9912882943 | Hyderabad, India | 24 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6905 | 58 | Inquiry |
| VASIN BIO LIFE SCIENCES PVT LTD | 9491644688 | Hyderabad, India | 2092 | 58 | Inquiry |
| TSK Lifesciences | 91-9397306789 | Hyderabad, India | 246 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| SynthoCascade Research Laboratories | 58 |
| JSK Chemicals | 58 |
| Suven Pharmaceuticals Limited | 58 |
| ALS INDIA LIFE SCIENCES | 58 |
| ASM Organics | 58 |
| Vivera Labs | 58 |
| Alfa Aesar | 58 |
| VASIN BIO LIFE SCIENCES PVT LTD | 58 |
| TSK Lifesciences | 58 |
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