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1-Tetralone

1-Tetralone Structure
CAS No.
529-34-0
Chemical Name:
1-Tetralone
Synonyms
tetralone;3,4-Dihydronaphthalen-1(2H)-one;α-Tetralone;A-TETRALONE;3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE;ALPHA-TETRALONE;Tetralin-1-one;1(2H)-Naphthalenone;2,3,4-Trihydronaphthalen-1-one;3,4-dihydro-1(2h)-naphthalenon
CBNumber:
CB7357499
Molecular Formula:
C10H10O
Molecular Weight:
146.19
MOL File:
529-34-0.mol
MSDS File:
SDS
Modify Date:
2024/5/21 17:03:17

1-Tetralone Properties

Melting point 2-7 °C(lit.)
Boiling point 113-116 °C6 mm Hg(lit.)
Density 1.099 g/mL at 25 °C(lit.)
refractive index n20/D 1.568(lit.)
Flash point >230 °F
storage temp. 2-8°C
solubility Chloroform, Ethyl Acetate (Slightly)
form Liquid
color brown
Water Solubility insoluble
BRN 607374
InChIKey XHLHPRDBBAGVEG-UHFFFAOYSA-N
CAS DataBase Reference 529-34-0(CAS DataBase Reference)
NIST Chemistry Reference 1(2H)-Naphthalenone, 3,4-dihydro-(529-34-0)
EPA Substance Registry System 1,2,3,4-Tetrahydronaphthalen-1-one (529-34-0)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn
Risk Statements  22-20/22-20/21/22
Safety Statements  23-24/25-36
WGK Germany  3
RTECS  QK4375000
TSCA  Yes
HS Code  29143900
Toxicity LD50 orally in Rabbit: 810 mg/kg LD50 dermal Rabbit > 2200 mg/kg
NFPA 704
1
1 0

1-Tetralone price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) T19003 α-Tetralone 97% 529-34-0 5G ₹2284.08 2022-06-14 Buy
Sigma-Aldrich(India) T19003 α-Tetralone 97% 529-34-0 100G ₹3561.43 2022-06-14 Buy
Sigma-Aldrich(India) T19003 α-Tetralone 97% 529-34-0 500G ₹11398.73 2022-06-14 Buy
Sigma-Aldrich(India) PHR3081 Phenylbutyrate Related Compound B pharmaceutical secondary standard, certified reference material 529-34-0 200MG ₹51635.25 2022-06-14 Buy
Sigma-Aldrich(India) 8.08203 1,2,3,4-Tetrahydro-1-naphthalenone for synthesis 529-34-0 100ML ₹6950 2022-06-14 Buy
Product number Packaging Price Buy
T19003 5G ₹2284.08 Buy
T19003 100G ₹3561.43 Buy
T19003 500G ₹11398.73 Buy
PHR3081 200MG ₹51635.25 Buy
8.08203 100ML ₹6950 Buy

1-Tetralone Chemical Properties,Uses,Production

Chemical Properties

Clear amber to brown oily liquid

Uses

1-Tetralone is a reagent used in the synthesis of amino-pyrazolopyridines with anti-NF-κB and pro-apoptotic potential.

Purification Methods

Check the IR first. Purify α-tetralone by dissolving 20mL in Et2O (200mL), washing with H2O (100mL), 5% aqueous NaOH (100mL), H2O (100mL), 3% aqueous AcOH (100mL), 5% NaHCO3 (100mL) then H2O (100mL) and dry the ethereal layer over MgSO4. Filter, evaporate and fractionate the residue through a 6in Vigreux column (p 11) under reduced pressure to give a colourless oil (~17g) with b 90-91o/0.50.7mm. [Snyder & Werber Org Synth Coll Vol III 798 1955.] It has also been fractionated through a 0.5metre packed column with a heated jacket under reflux using a partial take-off head. It has max 247.5 and 290nm (hexane). The phenylhydrazone has m 83o. The 2,4,6-trinitrophenylhydrazone has m 247.5-248o (from EtOH). [Olson & Bader Org Synth Coll Vol IV 898 1963, Beilstein 7 H 370, 7 III 1416, 7 IV 1015.]

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