L-655,708

CAS No.: 130477-52-0

Chemical Name:: L-655,708

Synonyms: MSD;L-655,708;L 655708,L655708;ETHYL (S)-11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLATE;Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate;11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1.5-a]pyrrolo[2.1-c][1.4]benzodiazepine-1-carboxylicacidethylester;(S)-ethyl 7-methoxy-9-oxo-11,12,13,13a- tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate;11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLIC ACID, ETHYL ESTER;9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)-;9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)- (011-14426_500Mg)

CBNumber:: CB4345633

Molecular Formula:: C18H19N3O4

Molecular Weight:: 341.36

MOL File:: 130477-52-0.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:09

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L-655,708 Properties

Melting point	175-176 °C
Boiling point	584.4±50.0 °C(Predicted)
Density	1.42±0.1 g/cm3(Predicted)
storage temp.	Desiccate at +4°C
solubility	DMSO: 6 mg/mL
form	powder
pka	1.49±0.20(Predicted)
color	White to yellow

SAFETY

Risk and Safety Statements

WGK Germany	3

L-655,708 price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	L9787	L-655,708 ≥98% (HPLC), powder	130477-52-0	5MG	₹9547.65	2022-06-14	Buy
Sigma-Aldrich(India)	L9787	L-655,708 ≥98% (HPLC), powder	130477-52-0	25MG	₹42780.4	2022-06-14	Buy

Product number	Packaging	Price	Buy
L9787	5MG	₹9547.65	Buy
L9787	25MG	₹42780.4	Buy

L-655,708 Chemical Properties,Uses,Production

Uses

L-655,708 has been used as an α5 GABAA receptor inverse agonist to inhibit the discriminative stimulus of propofol in a dose-dependent manner.

Biological Activity

Potent, selective inverse agonist for the benzodiazepine site of GABA A receptors containing the α 5 subunit (K i = 0.45 nM). Displays 50-100-fold selectivity over GABA A receptors containing α 1, α 2, α 3 or α 6 subunits in combination with β 3 and γ 2. Enhances LTP in? a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.

Biochem/physiol Actions

L-655,708 is an inverse agonist of the α5 γ-Aminobutyric acid type A (GABAA) receptor. It has an ability to increase cognition in rats.

L-655,708 Preparation Products And Raw materials

Raw materials

Preparation Products

L-655,708 Suppliers

Global( 67)Suppliers

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Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Labnetwork lnc.	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Nanjing Bicbiotechnology Co., Ltd	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Beijing Taize Ruida Technology Co., Ltd.	58

130477-52-0(L-655,708)Related Search:

[3H]-L-655,708,L-655,708, [1',1',1'-3H] 2-(1H-IMIDAZOL-1-YL)BENZENECARBOXAMIDE 2-IMIDAZOL-1-YL-BENZALDEHYDE 4-(5-METHYL-1H-IMIDAZOL-1-YL)PHENOL 4-(1H-IMIDAZOL-4-YL)-BUTYLAMINE

1-[2-(1H-IMIDAZOL-1-YL)PHENYL]METHANAMINE L-655,708

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9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)- 9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)- (011-14426_500Mg) MSD Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate 11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1.5-a]pyrrolo[2.1-c][1.4]benzodiazepine-1-carboxylicacidethylester 11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLIC ACID, ETHYL ESTER L-655,708 ETHYL (S)-11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLATE (S)-ethyl 7-methoxy-9-oxo-11,12,13,13a- tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate L 655708,L655708 130477-52-0 GABA/Glycine receptor