Ingenol

Ingenol Structure
CAS No.
30220-46-3
Chemical Name:
Ingenol
Synonyms
Ingeno;INGENOL;Inglenook;Ingenol, BR;(-)-Ingenol;Ingenol base;Ingenol >99%;Ingenol USP/EP/BP;INGENOL,HIGHPURITY;Ingenol 30220-46-3
CBNumber:
CB4370581
Molecular Formula:
C20H28O5
Molecular Weight:
348.43
MOL File:
30220-46-3.mol
Modify Date:
2024/1/4 11:05:11

Ingenol Properties

Melting point 153 °C
Boiling point 523.8±50.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO: soluble
form film
pka 12.06±0.70(Predicted)
color colorless

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05
Signal word  Danger
Hazard statements  H315-H318
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xi
Risk Statements  38-41
Safety Statements  26-36
WGK Germany  3
HS Code  2914409000

Ingenol price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemicals (India) I1112 Ingenol 30220-46-3 10MG ₹2600 2022-05-26 Buy
TCI Chemicals (India) I1112 Ingenol 30220-46-3 50MG ₹9800 2022-05-26 Buy
Product number Packaging Price Buy
I1112 10MG ₹2600 Buy
I1112 50MG ₹9800 Buy

Ingenol Chemical Properties,Uses,Production

Description

Ingenol is a diterpenoid related to phorbol, derived from the milkweed plant E. peplus. It is a protein kinase C activator that displays a Ki value of 30 μM and an ED50 value of 27 μM in vitro. Most ingenol esters are tumor-promoting. However, ingenol mebutate possesses anti-tumor activity when used topically for actinic keratosis.

Uses

Ingenol, is the analogue of Ingenol 3-Angelate (I655800), which has anti-tumor activity when used topically for the treatment of actinic keratosis.

Definition

ChEBI: A tetracyclic diterpenoid that is 1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one substituted at positions 5, 5a and 6 by hydroxy groups, positions 1, 1, 7 and 9 by met yl groups, position 4 by a hydroxymethyl group and position 1 by an oxo group (the 1aR,2S,5R,5aR,6S,8aS,9R,10aR diastere mer).

Global( 229)Suppliers
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Related articles

  • Total Synthesis of Ingenol
  • Isolated in 1968, ingenol (1), a highly oxygenated tetracyclic diterpene classified as a member of the phorboid family, is the....
  • Oct 30,2019
1A,2,5,5A,6,9,10,10A OCTAHYDRO-5,5A,6-TRIHYDROXY4(HYDROXYMETHYL)1,1,7,9-TETRAMETHYL1H-2,8 AMETHANOCYCLOPENTA[A]CYCLOPROPA[E]CYCLODECEN-11 ONE 1 ALPHA,2,5,5 ALPHA,6,9,10,10 ALPHA-OCTAHYDRO-5,5 ALPHA,6-TRIHYDROXY-4-HYDROXYMETHYL-1,1,7,9-RETRAMETHYL-1H-2,8 ALPHA-M INGENOL INGENOL \ ACTIVATES PROTEIN KINASE C (1ar,2s,5r,5ar,6s,8as,9r,10ar)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1h-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one INGENOL,HIGHPURITY 1alpha,2,5,5alpha,6,9,10,10alpha-Octahydro-5,5alpha,6-trihydroxy-4-hydroxymethyl-1,1,7,9,-retramethyl-1H-2,8alpha-m (1aR,2S,8aS)-1aα,2,5,5a,6,9,10,10aα-Octahydro-5β,5aβ,6β-trihydroxy-4-(hydroxymethyl)-1,1,7,9α-tetramethyl-2,8aα-methano-1H-cyclopenta[a]cyclopropa[e]cyclodecene-11-one (1aR,2S,8aS)-1aα,2,5,5a,6,9,10,10aα-Octahydro-5β,5aβ,6β-trihydroxy-4-hydroxymethyl-1,1,7,9α-tetramethyl-1H-2,8aα-methanocyclopenta[a]cyclopropa[e]cyclodecene-11-one Ingenol >99% Ingenol base (1aR,2S,5R,5aR,6S,8aS,9R,10aR)-5,5a,6-Trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one 1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one,1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-4-(hydroxyMethyl)-1,1,7,9-tetraMethyl-,(1aR,2S,5R,5aR,6S,8aS,9R,10aR)- Ingenol 30220-46-3 HPLC 99% purity Ingenol from Euphorbia lathyris 30220-46-3 99% Purity Ingenol Natural Plant Extracts 30220-46-3 Euphorbia Source Ingenol, BR Ingenol USP/EP/BP Inglenook (-)-Ingenol Ingeno 30220-46-3 BioChemical Cell Signaling and Neuroscience Cell Biology Protein Phosphorylation Protein Kinase Activators Activator