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Eliprodil

Eliprodil Structure
CAS No.
119431-25-3
Chemical Name:
Eliprodil
Synonyms
ELIPRODIL;SL 820715;1-(4-broMophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethanol;α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol;1-(4-chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol;α-(4-Chlorophenyl)-4-[(4-fluorophenyl)Methyl]-1-piperidineethanol;(+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol;(+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol;1-Piperidineethanol, α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-;ALPHA-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-1-PIPERIDINEETHANOL
CBNumber:
CB4373759
Molecular Formula:
C20H23ClFNO
Molecular Weight:
347.85
MOL File:
119431-25-3.mol
Modify Date:
2023/9/4 15:50:00
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Eliprodil Properties

Boiling point 474.1±35.0 °C(Predicted)
Density 1.205±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility DMSO: ~17 mg/mL
form solid
pka 13.99±0.20(Predicted)
color white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H319-H410
Precautionary statements  P273-P305+P351+P338-P501
Hazard Codes  N
Risk Statements  50/53
Safety Statements  60-61
RIDADR  UN 3077 9/PG 3
WGK Germany  3
NFPA 704
0
2 0

Eliprodil price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) E2031 Eliprodil ≥98% (HPLC), powder 119431-25-3 10MG ₹13350 2022-06-14 Buy
Sigma-Aldrich(India) E2031 Eliprodil ≥98% (HPLC), powder 119431-25-3 50MG ₹60100 2022-06-14 Buy
Sigma-Aldrich(India) 5.04539 Eliprodil - CAS 119431-25-3 - Calbiochem 119431-25-3 10MG ₹7470 2022-06-14 Buy
Product number Packaging Price Buy
E2031 10MG ₹13350 Buy
E2031 50MG ₹60100 Buy
5.04539 10MG ₹7470 Buy

Eliprodil Chemical Properties,Uses,Production

Description

N-Methyl-D-aspartate (NMDA) receptors are calcium permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. Eliprodil is a non-competitive NMDA receptor antagonist that inhibits neuronal calcium channel currents. It is selective for NR2B subunit-containing receptors (IC50 = 1 μM), displaying greater than 100-fold selectivity for NR2B over NR2A and NR2C subunits. Eliprodil also avidly binds σ1 and σ2 sites (Kis = 0.013 and 0.63 μM, respectively). It is effective in vivo, blocking ischemia-induced neurodegeneration in the CA1 region of the hippocampus of gerbils subjected to bilateral carotid artery occlusion. Eliprodil can also have proarrhythmic actions in hearts under normal conditions.

Uses

Eliprodil is a noncardiac drug with neuroprotective properties. It is also a N-Methyl-D-aspartate receptor (NMDAR) antagonist.

Biological Activity

Non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Selective for NR2B- over NR2A- and NR2C-containing receptors (IC 50 values are 1, > 100 and > 100 μ M respectively). Also σ 1 ligand (K i = 0.013 μ M). Antagonizes neuronal voltage-gated Ca 2+ channels and selectively inhibits the rapid component of the delayed rectifier K + current (I Kr ). Neuroprotective.

Eliprodil Preparation Products And Raw materials

Raw materials

Preparation Products

Eliprodil Suppliers

Global( 113)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29898 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
Alfa Chemistry United States 24072 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3136 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
Zhejiang J&C Biological Technology Co.,Limited 58
Alfa Chemistry 58
InvivoChem 58
Nantong HI-FUTURE Biology Co., Ltd. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58

Eliprodil Spectrum

Eliprodil(119431-25-3)1HNMR

119431-25-3(Eliprodil)Related Search:

7-Hydroxyisoflavone (7β,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic Acid γ-Lactone Methyl Ester Serotonin hydrochloride (R)-Eliprodil (S)-Eliprodil
4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE 4-(4-FLUOROBENZYL)PIPERIDINE HYDROCHLORIDE 4-(4'-Fluorobenzyl)piperidine Eliprodil
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SL 820715 ALPHA-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-1-PIPERIDINEETHANOL ELIPRODIL α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol SL 820715, α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol (+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol 1-(4-broMophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethanol 1-Piperidineethanol, α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]- α-(4-Chlorophenyl)-4-[(4-fluorophenyl)Methyl]-1-piperidineethanol 1-(4-chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol 119431-25-3 C20H23ClFNO Cell Biology BioChemical Cell Signaling and Neuroscience Ionotropic Glutamate Receptor Modulators Ion Channels Ligand-Gated Ion Channels Inhibitors Glutamate receptor Neuroprotective agent.