PODOPHYLLUM RESIN
- CAS No.
- 9000-55-9
- Chemical Name:
- PODOPHYLLUM RESIN
- Synonyms
- PODOPHYLLIN;podophyllum;Podophylline;podofillina;Podophyll resin;Podophyllum Resi;PODOPHYLLUM RESIN;PODOPHYLIUM RESIN;Resins Podophyllum;PODOCARPIC ACID(RG)
- CBNumber:
- CB4451718
- Molecular Formula:
- C88H92O34
- Molecular Weight:
- 1693.65168
- MOL File:
- 9000-55-9.mol
- Modify Date:
- 2024/4/22 15:59:48
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300+H310+H330-H314-H360 |
| Precautionary statements | P202-P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | T+ |
| Risk Statements | 61-26/27/28-34 |
| Safety Statements | 53-26-27-36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | TP8925000 |
PODOPHYLLUM RESIN price More Price(2)
PODOPHYLLUM RESIN Chemical Properties,Uses,Production
Chemical Properties
light yellow to brown powder
Uses
antiallergic
Indications
Podophyllin in a 10% to 25% suspension in a tincture of benzoin or alcohol can be used with success. Since this compound contains two mutagens, quercetin and kaempherol, it should used with caution in the physician’s office. It should stay on for 1 to 4 hours and be applied every week for 4 to 6 weeks. Podofilox (0.05 mL of 5%) is safer than podophyllin and should be self-applied twice a day for 3 days followed by 4 rest days to complete a treatment cycle. Topical 0.5% podophyllotoxin cream has been used b.i.d. for 3 consecutive days for a maximum of 4 weeks with clearance in 54% of patients. Podophyllum resin (podophyllin), or podofilox, a cytotoxic agent that arrests mitosis in metaphase, is used primarily for treatment of condyloma acuminata but may also be used on all other types of warts. Although now rarely available, a 25% preparation of podophyllum in compound tincture of benzoin should be applied overnight when treating common nongenital warts. A more commonly available preparation, podofilox 0.5% gel (Condylox), should be applied twice a day for 3 days, then discontinued for 4 consecutive days. The same cycle is continued until eradication of the lesions. The effectiveness as well as the irritant potential of this medication may be increased by covering with adhesive tape or plastic tape (Blenderm).
World Health Organization (WHO)
Podophyllum resin, which is extracted from Indian podophyllum, is highly irritant to the skin and mucous membranes and its use in purgatives is now obsolescent. However, topical preparations remain available for the treatment of venereal and other warts and the drug is included in the WHO Model List of Essential Drugs for this purpose. Podophyllin extracts have been demonstrated to have a teratogenic potential which has led to their withdrawal in some countries and restriction of use in others. They are best avoided during pregnancy. (Reference: (WHTAC1) The Use of Essential Drugs, 2nd Report of the WHO Expert Committee, 722, , 1985)
General Description
Podophyllin is an alcoholic plant extract, obtained from the dried rhizome and roots of?Podoplryllui emodi. It is a powder with colors varying from light brown to greenish-yellow and exposure to heat or light turns it darker.
Mechanism of action
Podophyllum resin (podophyllin) is a chemically complex extract obtained from the roots of either of the two plants: Podophyllum peltatum (American) or Podophyllum emodi (Indian) (also called Mandrake or May-apple). Podofilox is the most cytotoxic ingredient in podophyllum resin (present in concentrations of 15% to 20% in P. peltatum and 30% to 40% in P. emodi resins) and exerts its effect by binding to intracellular microtubular proteins and thereby preventing the development of the mitotic spindle. In vitro, podophyllum also inhibits RNA synthesis. Podophyllum is used in the treatment of condyloma acuminata and other warts.
Side effects
Podophyllin can cause severe irritation and, if absorbed in large quantities, may produce systemic toxic effects. It is inadvisable to apply it in large amounts to mucous membranes, and it is unwise to use it in pregnant women because of its possible cytotoxic action on the fetus.
Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. An irritant to skin, eyes, and mucous membranes. Questionable carcinogen with experimental neoplastigenic data. An experimental teratogen. Other experimental reproductive effects. Combustible when exposed to heat or flames. When heated to decomposition it emits acrid smoke and irritating fumes.
PODOPHYLLUM RESIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Himpharm | +91-9816648055 +91-9816664455 | Himachal Pradesh, India | 29 | 58 | Inquiry |
| Merck Ltd | +91-2262109800 +91-2262109000 | Maharashtra, India | 272 | 58 | Inquiry |
| Inga Pharmaceuticals | +91-2228202932 +91-2228202932 | Maharashtra, India | 38 | 58 | Inquiry |
| Namiex Chemicals Private Limited | +91-1862225256 +91-9988625256 | Punjab, India | 13 | 58 | Inquiry |
| Synnat Pharma Pvt Ltd | +91-9966980001 +91-9989984964 | AndhraPradesh, India | 22 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Doshil | 08048372652Ext 357 | Mumbai, India | 117 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Himpharm | 58 |
| Merck Ltd | 58 |
| Inga Pharmaceuticals | 58 |
| Namiex Chemicals Private Limited | 58 |
| Synnat Pharma Pvt Ltd | 58 |
| OCEAN TRADING CORPORATION | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
| Triveni chemicals | 58 |
| Doshil | 58 |
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