Tivozanib (hydrate)

CAS No.: 682745-40-0

Chemical Name:: Tivozanib (hydrate)

Synonyms: Tivozanib (hydrate);N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-urea,monohydrate

CBNumber:: CB44666310

Molecular Formula:: C22H21ClN4O6

Molecular Weight:: 472.88

MOL File:: 682745-40-0.mol

Modify Date:: 2023/5/21 10:59:17

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Tivozanib (hydrate) Properties

storage temp.	Store at -20°C
solubility	≤25mg/ml in DMSO;30mg/ml in dimethyl formamide
form	crystalline solid

Tivozanib (hydrate) Chemical Properties,Uses,Production

Description

Tivozanib is an orally available, selective VEGFR inhibitor with IC₅₀ values of 0.21, 0.16, and 0.24 nM for VEGFR1, VEGFR2, and VEGFR3, respectively. It can also inhibit c-Kit and PDGFRβ with IC₅₀ values of 1.63 and 1.72 nM, respectively. When administered to athymic rats, tivozanib was shown to decrease the microvessel density within tumor xenografts and attenuate VEGFR2 phosphorylation levels in tumor endothelium. It also displays antitumor activity against a wide variety of human tumor xenografts, including lung, breast, colon, ovarian, pancreas, and prostate cancer.

Tivozanib (hydrate) Preparation Products And Raw materials

Raw materials

Preparation Products

Tivozanib (hydrate) Suppliers

Global( 12)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
ApexBio Technology	+ 1-832-696-8203	United States	6254	58	Inquiry
Boao Pike	010-57798038 15652371397	CHINA	6629	58	Inquiry
Beijing Bolide Biotechnology Co., Ltd.	010-51653916	CHINA	6172	58	Inquiry
Shanghai Weiwei Biological Technology Co., Ltd.	021-55669583 18616258598	CHINA	4398	58	Inquiry
Morning Student Science and Technology (Guangzhou) Co., Ltd.	020-36048871 13760856740	CHINA	6618	58	Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd.	15800340161	CHINA	6846	58	Inquiry
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	China	11289	58	Inquiry
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	China	8141	58	Inquiry
Cayman Chemical Company	(800) 364-9897	United States	6618	81	Inquiry
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	China	8736	58	Inquiry

Supplier	Advantage
ApexBio Technology	58
Boao Pike	58
Beijing Bolide Biotechnology Co., Ltd.	58
Shanghai Weiwei Biological Technology Co., Ltd.	58
Morning Student Science and Technology (Guangzhou) Co., Ltd.	58
Shanghai Hao Zhun Biological Technology Co., Ltd.	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
MedBioPharmaceutical Technology Inc	58
Cayman Chemical Company	81
Shanghai Yifei Biotechnology Co. , Ltd.	58

682745-40-0(Tivozanib (hydrate))Related Search:

Tivozanib 3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione

Tivozanib (hydrate) N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-urea,monohydrate 682745-40-0 C22H19ClN4O5H2O