PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2
- CAS No.
- 39024-57-2
- Chemical Name:
- PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2
- Synonyms
- LHG-17;[Leu15]-HG-17;[LEU15]-GASTRIN I;gastrin I, human Leu15;(LEU15)-GASTRIN I (HUMAN);(Leu??)-Gastrin I (human);[Leucine15]-Little gastrin I;(Leu15)-Gastrin-17 I (human);[15-leucine]gastrin I, human;(15-LEUCINE) HUMAN GASTRIN I
- CBNumber:
- CB4485427
- Molecular Formula:
- C98H126N20O31
- Molecular Weight:
- 2080.2
- MOL File:
- 39024-57-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:09
Boiling point | 2368.8±65.0 °C(Predicted) |
---|---|
Density | 1.400±0.06 g/cm3(Predicted) |
storage temp. | −20°C |
pka | 4.20±0.10(Predicted) |
form | Solid |
color | White to off-white |
BRN | 5227423 |
Sequence | Pyr-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2 |
PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 price More Price(2)
PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 Chemical Properties,Uses,Production
Uses
Gastrin has been used:
- as a medium supplement establish enteroid cultures
- as a supplement to standard Dulbecco′s Modified Eagle Medium (DMEM) culture medium, human minigut medium to establish the growth of crypts.
General Description
GAST gene encodes for the protein [Leu15]-Gastrin I in human. In human chromosome, the gene GAST is localized on 17q21.2. G cells in the stomach antrum produces the precursor of [Leu15]-Gastrin I, progastrin. Progastrin undergoes cleavage and processing to yield gastrin, which is trophic for the entire gastrointestinal epithelium. Gastrin is essential for the growth of the digestive system and stimulates the production of gastric acid by parietal cells. Gastrin exerts its function through G-protein-coupled receptor called the cholecystokinin (CCK) or CCK-B receptor (CCK-BR). Gastrin release is stimulated by food, especially protein diet and is inhibited by very low pH. Atrophic gastritis, a Helicobacter pylori infection and long-term administration of proton pump inhibitors infection may cause overexpression of gastrin. Gastric adenocarcinoma show high levels of gastrin.
Biochem/physiol Actions
Gastrin I analog with full biological activity and improved stability in aqueous solutions. Leu15 replaces Met15, that is readily oxidized resulting in loss of biological activity.
PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 Preparation Products And Raw materials
Raw materials
Preparation Products
PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10311 | 58 | Inquiry |
BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
Cellmano Biotech Limited | 0551-65326643 18156095617 | China | 999 | 58 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29824 | 58 | Inquiry |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | China | 2345 | 58 | Inquiry |
LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | China | 3581 | 58 | Inquiry |
39024-57-2(PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2)Related Search:
1of2
chevron_right