PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2

PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 Structure
CAS No.
39024-57-2
Chemical Name:
PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2
Synonyms
LHG-17;[Leu15]-HG-17;[LEU15]-GASTRIN I;gastrin I, human Leu15;(LEU15)-GASTRIN I (HUMAN);(Leu??)-Gastrin I (human);[Leucine15]-Little gastrin I;(Leu15)-Gastrin-17 I (human);[15-leucine]gastrin I, human;(15-LEUCINE) HUMAN GASTRIN I
CBNumber:
CB4485427
Molecular Formula:
C98H126N20O31
Molecular Weight:
2080.2
MOL File:
39024-57-2.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:09

PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 Properties

Boiling point 2368.8±65.0 °C(Predicted)
Density 1.400±0.06 g/cm3(Predicted)
storage temp. −20°C
pka 4.20±0.10(Predicted)
form Solid
color White to off-white
BRN 5227423
Sequence Pyr-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2

SAFETY

Risk and Safety Statements

WGK Germany  3

PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) G9145 [Leu15]-Gastrin I human ≥95% (HPLC) 39024-57-2 0.1MG ₹9471.88 2022-06-14 Buy
Sigma-Aldrich(India) G9145 [Leu15]-Gastrin I human ≥95% (HPLC) 39024-57-2 0.5MG ₹27798.6 2022-06-14 Buy
Product number Packaging Price Buy
G9145 0.1MG ₹9471.88 Buy
G9145 0.5MG ₹27798.6 Buy

PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 Chemical Properties,Uses,Production

Uses

Gastrin has been used:

  • as a medium supplement establish enteroid cultures
  • as a supplement to standard Dulbecco′s Modified Eagle Medium (DMEM) culture medium, human minigut medium to establish the growth of crypts.

General Description

GAST gene encodes for the protein [Leu15]-Gastrin I in human. In human chromosome, the gene GAST is localized on 17q21.2. G cells in the stomach antrum produces the precursor of [Leu15]-Gastrin I, progastrin. Progastrin undergoes cleavage and processing to yield gastrin, which is trophic for the entire gastrointestinal epithelium. Gastrin is essential for the growth of the digestive system and stimulates the production of gastric acid by parietal cells. Gastrin exerts its function through G-protein-coupled receptor called the cholecystokinin (CCK) or CCK-B receptor (CCK-BR). Gastrin release is stimulated by food, especially protein diet and is inhibited by very low pH. Atrophic gastritis, a Helicobacter pylori infection and long-term administration of proton pump inhibitors infection may cause overexpression of gastrin. Gastric adenocarcinoma show high levels of gastrin.

Biochem/physiol Actions

Gastrin I analog with full biological activity and improved stability in aqueous solutions. Leu15 replaces Met15, that is readily oxidized resulting in loss of biological activity.

PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 Suppliers

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H-PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 [LEU15]-GASTRIN I PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 PGLU-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 leu(15)-gastrinheptadecapeptid 18-(5-Oxo-L-proline)-22-L-leucine-32-L-leucine-18-34-gastrinI【pig】 5-Oxo-L-Pro-Gly-L-Pro-L-Trp-L-Leu-L-Glu-L-Glu-L-Glu-L-Glu-L-Glu-L-Ala-L-Tyr-Gly-L-Trp-L-Leu-L-Asp-L-Phe-NH2 (Leu15)-Gastrin I (huMan) (Leu15)-Gastrin-17 I (huMan), (Pyr18,Leu22,Leu32)-Gastrin I (18-34) (porcine) (Leu15)-Gastrin-17 I (huMan), (Pyr18,Leu22,Leu32)-Gastrin I (18-34) (porcine) [18-Pyroglutamic acid, 32-leucine]-Big gastrin I-(18-34)-peptide amide, human [Leu15]-HG-17 [Leucine15]-Gastrin I heptadecapeptide [Leucine15]-Little gastrin I LHG-17 (Leu15)-Gastrin-17 I (human) 18-34-Gastrin I (pig), 18-(5-oxo-l-proline)-22-l-leucine-32-l-leucine- [15-leucine]-gastrin i, human heptadecapeptide gastrin heptadecapeptide, Leu(15)- gastrin I, human Leu15 [15-leucine]gastrin I, human [15-Leucine]-Gastrin I, human heptadecapeptide, [Leu15]-Gastrin I, human, [Leu15]-HG-17, [Leucine15]-Gastrin I heptadecapeptide, [Leucine15]-Little gastrin I, LHG-17, [18-Pyroglutamic acid, 32-leucine]-Big gastrin I-(18-34)-peptide amide, human (15-LEUCINE) HUMAN GASTRIN I (LEU15)-GASTRIN I (HUMAN) L-Phenylalaninamide, 5-oxo-L-prolylglycyl-L-prolyl-L-tryptophyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-tyrosylglycyl-L-tryptophyl-L-leucyl-L-α-aspartyl- Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2 (Leu??)-Gastrin I (human) 39024-57-2 C98H126N20O31 Gastrins Gastrointestinal Products Peptides BioChemical Amino Acids and Peptides Biochemicals and Reagents