MONOBEHENIN
- CAS No.
- 30233-64-8
- Chemical Name:
- MONOBEHENIN
- Synonyms
- MONOBEHENIN;1-MONOBEHENIN;KeMester 6500;MONODOCOSANOIN;Glycetyl Behenate;Glyceryl monobehenate;Docosanoin, Mono- (7CI);Monostearin Impurity 37;Behenic acid monoglyceride;n-Docosanoicacidglycerolester
- CBNumber:
- CB4489612
- Molecular Formula:
- C25H50O4
- Molecular Weight:
- 414.66
- MOL File:
- 30233-64-8.mol
- Modify Date:
- 2024/7/18 18:48:51
| Density | 0.93[at 20℃] |
|---|---|
| vapor pressure | 0.001Pa at 25℃ |
| solubility | Soluble, when heated, in chloroform and dichloromethane and in many organic solvents; slightly soluble in hot ethanol (96%); practically insoluble in cold ethanol (95%), hexane, mineral oil, and water. |
| form | A solid |
| color | White to off-white |
| Water Solubility | 100ng/L at 25℃ |
| LogP | 8.58 at 25℃ |
| EPA Substance Registry System | Docosanoic acid, monoester with 1,2,3-propanetriol (30233-64-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
MONOBEHENIN Chemical Properties,Uses,Production
Chemical Properties
Glyceryl behenate occurs as a fine white-yellow powder, as a hard waxy mass or pellet, or as white or almost white unctuous flakes. It has a faint odor.
Production Methods
Glyceryl behenate is prepared by the esterification of glycerin by behenic acid (C22 fatty acid) without the use of catalysts. In the case of Compritol 888 ATO (Gattefosse′), raw materials used are of vegetable origin, and the esterified material is atomized by spraycooling.
Pharmaceutical Applications
Glyceryl behenate is used in cosmetics, foods, and oral pharmaceutical
formulations.
In pharmaceutical formulations, glyceryl behenate is mainly used
as a lubricant in the preparation of oral tablets and capsules. It
has good binding properties, it does not affect tablet hardness and is
unaffected by mixing or production parameters. Glyceryl behenate
has been investigated for the encapsulation of various drugs such as
retinoids. It has also been investigated for use in the preparation
of sustained-release tablets; as a matrix-forming agent for the
controlled release of water-soluble drugs; and it can also be used
as a hot-melt coating agent sprayed onto a powder or drug-loaded
sugar beads and granules. It may also be incorporated via
extrusion/spheronization into pellets, which can be further compressed
into tablets.
Glyceryl behenate is used in oral enteric-coated pellets, powders
and suspensions. It is also used in controlled, extended-release and
orally disintegrating tablets. For oral preparations, glyceryl
behenate forms a lipidic matrix for sustained-release formulations.
It has been used along with acid-soluble or swellable polymers to
mask the bitter or unpleasant taste of the medicament with
improved palatability.
Glyceryl behenate has been used for the preparation of
ophthalmic inserts.
In cosmetics, glyceryl behenate is used as a skin conditioning
agent, emollient and viscosity-increasing agent in emulsions. It also
improves the heat stability of emulsions and is a gelifying agent for
various oils. For topical formulations, it is used as a thickening
agent for oily phases. It is also used as a surfactant or emulsifying
agent.
Safety
Glyceryl behenate is used in cosmetics, foods and oral pharmaceutical
formulations, and is generally regarded as a relatively
nonirritant and nontoxic material. The US Cosmetic Ingredients
Review Expert Panel evaluated glyceryl behenate and concluded
that it is safe for use in cosmetic formulations in present practices of
use and concentration.
LD50 (mouse, oral): 5 g/kg
storage
Glyceryl behenate should be stored in a tightly closed container, at a temperature less than 35°C.
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules, tablets, and suspensions). Included in the Canadian List of Acceptable Non-medicinal Ingredients.
MONOBEHENIN Preparation Products And Raw materials
MONOBEHENIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jiangxi Alpha Hi-tech Pharmaceutical Co., Ltd | 510-85010237 | CHINA | 41 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | China | 3957 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12446 | 58 | Inquiry |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | China | 3002 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | China | 8821 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29824 | 58 | Inquiry |
| Univar Solutions(China) Co., Ltd. | +8615902132654 | China | 654 | 58 | Inquiry |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | China | 13341 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | China | 5989 | 58 | Inquiry |