KNK437
- CAS No.
- 218924-25-5
- Chemical Name:
- KNK437
- Synonyms
- KNK437;KNK423;CS-1681;KNK-437;KNK 437;HEAT SHOCK PROTEIN INHIBITOR I;HEAT SHOCK PROTEIN INHIBITOR II;KNK 437 (Heat Shock Protein Inhibitor I);3,4-METHYLENEDIOXY-BENZYLIDINE-GAMMA-BUTYROLACTAM;N-Formyl-3,4-methylenedioxy-benzylidene-g-butyrolactam;N-FORMYL-3,4-METHYLENEDIOXY-BENZYLIDINE-GAMMA-BUTYROLACTAM
- CBNumber:
- CB4713272
- Molecular Formula:
- C13H11NO4
- Molecular Weight:
- 245.23
- MOL File:
- Mol file
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:06
| Boiling point | 412.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.515±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| form | White to light yellow powder |
| pka | -1.70±0.20(Predicted) |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
KNK437 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0964 | KNK437 ≥98% (HPLC) | 218924-25-5 | 5MG | ₹11528.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0964 | KNK437 ≥98% (HPLC) | 218924-25-5 | 25MG | ₹46515.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 373260 | Heat Shock Protein Inhibitor I - CAS 218924-25-5 - Calbiochem Heat Shock Protein Inhibitor I, CAS 218924-25-5 blocks the induction of HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose- | 218924-25-5 | 5MG | ₹24680 | 2022-06-14 | Buy |
KNK437 Chemical Properties,Uses,Production
Uses
KNK437 has been used:
- as a heat shock factor 1 (HSF1) inhibitor to study its effects on the inhibition of viability and apoptosis activation in chemoresistant mice cells
- as an HSF1 inhibitor to study its effects on viability and apoptosis of colorectal cancer cells
- as a heat shock protein 70 (HSP70) inhibitor to study its effects on glutamine-induced HSP70 and inflammatory mediator release
Biochem/physiol Actions
KNK437 inhibits the accumulation of heat shock proteins (including hsp -27, -40, -70, -72 and -105). KNK437 inhibits thermotolerance in cells with greater potency than quercetin.
KNK437 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 77)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5738 | 58 | Inquiry |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | China | 694 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
N-FORMYL-3,4-METHYLENEDIOXY-BENZYLIDINE-GAMMA-BUTYROLACTAM
3,4-METHYLENEDIOXY-BENZYLIDINE-GAMMA-BUTYROLACTAM
KNK423
KNK437
HEAT SHOCK PROTEIN INHIBITOR I
HEAT SHOCK PROTEIN INHIBITOR II
3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde
Heat Shock Protein Inhibitor I - CAS 218924-25-5 - Calbiochem
CS-1681
3-[(E)-1,3-Benzodioxol-5-ylmethylene]-2-oxopyrrolidine-1-carbaldehyde
KNK-437;KNK 437
1-Pyrrolidinecarboxaldehyde, 3-(1,3-benzodioxol-5-ylmethylene)-2-oxo-
N-Formyl-3,4-methylenedioxy-benzylidene-g-butyrolactam
3-(Benzo[d][1,3]dioxol-5-ylmethylene)-2-oxopyrrolidine-1-carbaldehyde
HSP,inhibit,Heat shock proteins,KNK-437,KNK437,KNK 437,Inhibitor
KNK 437 (Heat Shock Protein Inhibitor I)
218924-25-5
API
Inhibitors