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BISINDOLYLMALEIMIDE III

BISINDOLYLMALEIMIDE III Structure
CAS No.
137592-43-9
Chemical Name:
BISINDOLYLMALEIMIDE III
Synonyms
BISINDOLYLMALEIMIDE III;3-[1-(3-aminopropyl)indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione;3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-
CBNumber:
CB4728487
Molecular Formula:
C23H20N4O2
Molecular Weight:
384.43
MOL File:
Mol file
Modify Date:
2024/7/2 8:55:09
Request For Quotation

BISINDOLYLMALEIMIDE III Properties

Boiling point 708.7±60.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
solubility DMSO: soluble; Methanol: soluble
form A crystalline solid
pka 8.15±0.60(Predicted)
color Brown to reddish brown

BISINDOLYLMALEIMIDE III Chemical Properties,Uses,Production

Description

Bisindolylmaleimide III was developed as a protein kinase C (PKC) inhibitor with structural similarity to the nonspecific PKC inhibitor staurosporine. At 1 μM, bisindolylmaleimide III inhibits 93% of PKCα kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-K1, RSK2 and MSK1 with similar potency. Additionally, it inhibits PDK1, an important kinase in the insulin signaling pathway, with an IC50 value of 3.8 μM.

Uses

Bisindolylmaleimide III is a protein kinase C inhibitor and was also shown to exhibit inhibitory activities towards PDK1, an important kinase in the insulin signaling pathway,

BISINDOLYLMALEIMIDE III Preparation Products And Raw materials

Raw materials

Preparation Products

BISINDOLYLMALEIMIDE III Suppliers

Global( 25)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826 China 48467 58 Inquiry
Bide Pharmatech Ltd. 400-1647117 15221909166 China 63720 58 Inquiry
TargetMol Chemicals Inc. 15002134094 China 28091 58 Inquiry
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 China 3770 55 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 China 9707 58 Inquiry
Alexis Corporation +41 61 926 8989 Switzerland 3599 74 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Aladdin Scientific 58
Aladdin Scientific 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Cayman Chemical Company 81
Shanghai EFE Biological Technology Co., Ltd. 58
Alexis Corporation 74

137592-43-9(BISINDOLYLMALEIMIDE III)Related Search:

GF109203X
BISINDOLYLMALEIMIDE III 3-[1-(3-aminopropyl)indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione 1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)- 3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione 137592-43-9 Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals