DIAPHORASE
| storage temp. | -20°C |
|---|---|
| form | lyophilized powder |
| color | light brown-yellow |
| EPA Substance Registry System | Dehydrogenase, lipoamide (9001-18-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| F | 3-10 |
| TSCA | Yes |
| HS Code | 3507909090 |
DIAPHORASE price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D5540 | Diaphorase from Clostridium kluyveri lyophilized powder, 3.0-20.0?units/mg protein (biuret) | 9001-18-7 | 100UNITS | ₹7881 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | WH0001728M1 | Monoclonal Anti-NQO1 antibody produced in mouse clone 1E3-A6, purified immunoglobulin, buffered aqueous solution | 9001-18-7 | 100μG | ₹48018.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D5540 | Diaphorase from Clostridium kluyveri lyophilized powder, 3.0-20.0?units/mg protein (biuret) | 9001-18-7 | 300UNITS | ₹20868 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SAB5300233 | Monoclonal Anti-NQO1 antibody produced in mouse clone 1A11, ascites fluid | 9001-18-7 | 100μL | ₹52347.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SAB5300232 | Monoclonal Anti-NQO1 antibody produced in mouse clone 4D12, ascites fluid | 9001-18-7 | 100μL | ₹52347.6 | 2022-06-14 | Buy |
DIAPHORASE Chemical Properties,Uses,Production
Uses
Diaphorase from Clostridium kluyveri, or Lipoyl dehydrogenase, has been used in a study to assess the protein-protein interactions in assembly of lipoic acid on the 2-oxoacid dehydrogenases of aerobic metabolism. Lipoyl dehydrogenase has also been used in a study to investigate the redox regulation of tyrosine nitration and 3-nitrotyrosine reduction by antioxidants.
Biochem/physiol Actions
Diaphorase catalyzes the oxidation of either β-NADH or β-NADPH in the presence of an electron acceptor such as methylene blue or 2,6-dichlorophenolindophenol. Diaphorases which are specific for either β-NADH or β-NADPH are known. The pig heart enzyme of Straub seems to have native diaphorase (β-NADH specific) as well as lipoic and lipoamide dehydrogenase activities. It is reported to be a single protein. However, Massey reports that diaphorase is probably a denatured lipoamide dehydrogenase. Pre-incubation of the pig heart preparation with Cu2+ reduces the lipoamide dehydrogenase activity and proportionately increases the β-NADH diaphorase activity. In our laboratory, we have demonstrated this copper effect to some degree on the pig heart enzyme, but no appreciable effect was observed on the Clostridium kluyveri or torula yeast preparations. The lipoamide dehydrogenase:diaphorase ratio is a measure of the denaturation.
DIAPHORASE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 25196 | 58 | Inquiry |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | China | 5990 | 58 | Inquiry |
| Hzymes Biotechnology Co. LTD | +86-02160879177 +86-13849862354 | China | 116 | 58 | Inquiry |
| Nanjing Duly Biotech Co.,Ltd | +undefined18013301590 | China | 2452 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
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