PENTOSTATIN | 53910-25-1

PENTOSTATIN Properties

Melting point	154-157?C
alpha	D25 +76.4° (c = 1 in water); D23 +73.0° (c = 1, pH 7 buffer)
Boiling point	411.43°C (rough estimate)
Density	1.2576 (rough estimate)
refractive index	1.6081 (estimate)
storage temp.	-20°C
solubility	H2O: soluble10mg/mL, clear
pka	5.2(at 25℃)
form	White solid
color	white to beige
optical activity	[α]/D +70 to +80°, c = 1 in H2O

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301

Precautionary statements

P301+P310

Hazard Codes

Xn

Risk Statements

22

RIDADR

UN 2811 6.1 / PGIII

WGK Germany

3

HS Code

2933998090

Toxicity

LD50 oral in mouse: 227mg/kg

NFPA 704

	0
2		0

PENTOSTATIN price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0508	Pentostatin ≥95% (HPLC)	53910-25-1	5MG	₹10846.65	2022-06-14	Buy
Sigma-Aldrich(India)	SML0508	Pentostatin ≥95% (HPLC)	53910-25-1	25MG	₹43830.43	2022-06-14	Buy
Sigma-Aldrich(India)	116860	Adenosine Deaminase Inhibitor, DCF - CAS 53910-25-1 - Calbiochem The Adenosine Deaminase Inhibitor, DCF, also referenced under CAS 53910-25-1, controls the biological activity of Adenosine Deaminase.	53910-25-1	10MG	₹14260	2022-06-14	Buy

Product number	Packaging	Price	Buy
SML0508	5MG	₹10846.65	Buy
SML0508	25MG	₹43830.43	Buy
116860	10MG	₹14260	Buy

PENTOSTATIN Chemical Properties,Uses,Production

Description

Pentostatin, an adenosine deaminase inhibitor, is an orphan drug introduced for the treatment of hairy cell leukemia. The agent is considered a significant advance over alpha-interferon, the only other drug available for this indication. The majority of patients treated with pentostatin have been reported to remain in remission for at least four years. It is also under investigation for the treatment of other kinds of leukemia and in transplant rejection.

Chemical Properties

White Solid

Uses

Pentostatin is a potent antitumour antibiotic isolated from a Streptomyces species. Pentostatin is a potent inhibitor of adenine deaminase and has been used therapeutically as an antitumour agent.

Indications

Pentostatin (Nipent, deoxycoformycin) is a purine isolated from fermentation cultures of the microbe Streptomyces antibioticus. Its mechanism of action involves inhibition of the enzyme adenosine deaminase, which plays an important role in purine salvage pathways and DNA synthesis.The resulting accumulation of deoxyadenosine triphosphate (dATP) is highly toxic to lymphocytes.
Pentostatin is effective in the therapy of hairy cell leukemia, producing remissions in 80 to 90% of patients and complete remissions in more than 50%. The major toxic effects of the drug include myelosuppression, nausea, and skin rashes.

brand name

Nipent (SuperGen), Coforin (Katetsuken).

General Description

The drug is available in 10-mg vials for IV use. The drug isused to treat leukemias such as hairy cell leukemia, chroniclymphocytic leukemia, and lymphoblastic leukemia. Themechanism of action involves inhibition of the enzymeadenosine deaminase yielding increased cellular levels ofdeoxyadenosine and deoxyadenosine triphosphate (dATP).The increased levels of dATP are cytotoxic to lymphocytes.Pentostatin is a fermentation product of Streptomyces antibioticus.Resistance appears to involve decreased cellulartransport or increased expression of catabolic enzymes.Acid instability prevents oral administration, and the drug isonly administered by IV. The drug is distributed in totalbody water but does not enter the CNS. The majority of thedosage is excreted unchanged in the urine. Fatal pulmonary toxicity has occurred when pentostatin and fludarabine areused in combination. Toxicities include myelosuppression,immunosuppression, nausea, vomiting, headache, lethargy,and fatigue.

Biological Activity

Irreversible inhibitor of adenosine deaminase (K i = 2.5 pM). Anticancer agent.

Mechanism of action

Pentostatin is the most potent inhibitor of adenosine deaminase, an important and ubiquitous cellular enzyme. Inhibition of this enzyme leads to the accumulation of dATP, which inhibits ribonucleotide reductase and thus DNA synthesis.

Clinical Use

Pentostatin is a ring-expanded purine ribonucleoside that inhibits adenosine deaminase and is used in the treatment of hairy cell leukemia. The elevated levels of deoxyadenosine triphosphate that result from inhibition of this degradative enzyme inhibit the action of ribonucleotide reductase (the enzyme that converts ribose diphosphate to deoxyribose diphosphate), thus halting DNA synthesis within the tumor cell.

Safety Profile

Poison by intravenous route. An experimental teratogen. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

PENTOSTATIN Preparation Products And Raw materials

Raw materials

Preparation Products

PENTOSTATIN Suppliers

Global( 196)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Apicore Pharmaceuticals Pvt Ltd	+91-2662267177 +91-2662267166	Gujarat, India	181	58	Inquiry
Manus Aktteva	+91 (79) 6512-3395	New Delhi, India	581	34	Inquiry
MYLAN API US LLC	080 6672 8000	New Delhi, India	44	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32836	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29824	58	Inquiry
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	China	10297	58	Inquiry
Hubei Ipure Biology Co., Ltd	+8613367258412	China	10326	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23555	58	Inquiry

Supplier	Advantage
Apicore Pharmaceuticals Pvt Ltd	58
Manus Aktteva	34
MYLAN API US LLC	58
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Fuxin Pharmaceutical	58
Hubei Ipure Biology Co., Ltd	58
ANHUI WITOP BIOTECH CO., LTD	58

PENTOSTATIN Spectrum

PENTOSTATIN(53910-25-1)¹HNMR

53910-25-1(PENTOSTATIN)Related Search:

NA Sodium deoxycholate Aclarubicin 4-Imidazolemethanol hydrochloride (1-METHYL-1H-IMIDAZOL-4-YL)METHANOL

4(5)-(2-amino-1-hydroxyethyl)imidazole PENTOSTATIN Imidazole-4-methanol

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2’-deoxycoformycin CL-67310465：NSC-218321 (8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol Pentostatin(Deoxycoformycin) Pentostatin, >=99% ci-825 cl67310465 co-vidarabine iazepin-8-ol imidazo(4,5-d)(1,3)diazepin-8-ol,3-(2-deoxy-beta-d-pentofuranosyl)-3,6,7,8-tet (8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8β-ol Coforin 2'-DeoxycoforMycin, Covidaribine, ADAI, CI 825, d-Cof, NSC 218321, PD-ADI, YK 176 nsc-218321 yk-176 Imidazo4,5-d1,3diazepin-8-ol, 3-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (8R)- Imidazo[4,5-d][1,3]diazepin-8-ol, 3-(2-deoxy-b-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (8R)- 2'-Dexoycoformycin Cl 825 Co-V Deaminase inhibitor Imidazo[4,5-d][1,3]diazepin-8-ol, 3-(2-deoxy-b-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (8R)- (9CI) Imidazo[4,5-d][1,3]diazepin-8-ol, 3-(2-deoxy-b-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)- NSC 247520 PD-ADI Vira A deaminase inhibitor 2''-DEOXYCOFORMYCIN (2''-DCF: NIPENT) -3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3，6，7，8-te-trahydroimidazo[4，5-d][1，3]diazepin-8-ol (R)-3-((2S,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol Adenosine Deaminase Inhibitor, DCF PENTOSTATIN (r)-3-(2-deoxy-beta-d-erythro-pento-furanosyl)-3,6,7,8-tetrahydroimidazo[4,5-d (r)-3-(2-deoxy-beta-d-pentofuranosyl)-3,6,7,8-tetrahydroimidazo(4,5-d)(1,3)d (r)-deoxycoformycin (r)-rahydro 2’dcf Vira A Deaminase Inhibito Imidazo[4,5-d][1,3]diazepin-8-ol, 3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (8R)- (R)-3-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol PENTOSTATIN USP/EP/BP Pentostatin (CI825 Pentostatin, 98%(HPLC) Adenosine Deaminase Inhibitor, DCF - CAS 53910-25-1 - Calbiochem (8R)-3-(2-Deoxy-b-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol dcf deoxycoformycin Nipent Reliable quality 53910-25-1 PENTOSTATIN (8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol PD-81565 PD 81565 PD81565 (8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol 53910-25-1 Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals