Disodium hydrogen phosphate dihydrate
- CAS No.
- 10028-24-7
- Chemical Name:
- Disodium hydrogen phosphate dihydrate
- Synonyms
- DISODIUM PHOSPHATE;DISODIUM HYDROGEN PHOSPHATE;DSP;DIBASIC SODIUM PHOSPHATE;DSPA;BUFFER SOLUTION;SODIUM PHOSPHATE, DIBASIC;Sodium phosphate dibasic dihydrate;SODIUM MONOHYDROGEN PHOSPHATE;FEMA 2398
- CBNumber:
- CB4852564
- Molecular Formula:
- 2Na.HO4P.2H2O
- Molecular Weight:
- 177.99
- MOL File:
- 10028-24-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/10/13 18:16:27
| Melting point | 92,5°C |
|---|---|
| Density | 1.064 g/mL at 20 °C |
| vapor density | 4.9 (vs air) |
| storage temp. | Store at +5°C to +30°C. |
| solubility | H2O: 0.5 M at 20 °C, clear, colorless |
| form | powder |
| color | White |
| Odor | Odorless |
| PH Range | 9.1 |
| PH | 8.9-9.2 (25℃, 0.5M in H2O) |
| Water Solubility | Soluble in water |
| λmax |
λ: 260 nm Amax: 0.03 λ: 280 nm Amax: 0.03 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | KDQPSPMLNJTZAL-UHFFFAOYSA-L |
| CAS DataBase Reference | 10028-24-7(CAS DataBase Reference) |
| EPA Substance Registry System | Disodium phosphate dihydrate (10028-24-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-24/25-22 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | WC4500000 |
| F | 3 |
| HS Code | 28352200 |
| Toxicity | LD50 orally in Rabbit: > 2000 mg/kg |
Disodium hydrogen phosphate dihydrate price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 71645 | Sodium phosphate dibasic dihydrate BioXtra, ≥98.0% (T) | 10028-24-7 | 1KG | ₹4124.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 71662 | Sodium phosphate dibasic dihydrate tested according to Ph. Eur. | 10028-24-7 | 1KG | ₹6126.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 71645 | Sodium phosphate dibasic dihydrate BioXtra, ≥98.0% (T) | 10028-24-7 | 5KG | ₹9558.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 71643 | Sodium phosphate dibasic dihydrate BioUltra, for molecular biology, ≥99.0% (T) | 10028-24-7 | 250G | ₹4611.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 30435 | Sodium phosphate dibasic dihydrate puriss. p.a., reag. Ph. Eur., 98.5-101.0% (calc. to the dried substance) | 10028-24-7 | 500G | ₹4698.05 | 2022-06-14 | Buy |
Disodium hydrogen phosphate dihydrate Chemical Properties,Uses,Production
Chemical Properties
solid
Uses
Laxative.
Production Methods
Either bone phosphate (bone ash), obtained by heating bones to
whiteness, or the mineral phosphorite is used as a source of tribasic
calcium phosphate, which is the starting material in the industrial
production of dibasic sodium phosphate.
Tribasic calcium phosphate is finely ground and digested with
sulfuric acid. This mixture is then leached with hot water and
neutralized with sodium carbonate, and dibasic sodium phosphate
is crystallized from the filtrate.
Definition
ChEBI: A hydrate that is the dihydrate form of disodium hydrogenphosphate
Pharmaceutical Applications
Dibasic sodium phosphate is used in a wide variety of pharmaceutical
formulations as a buffering agent and as a sequestering agent.
Therapeutically, dibasic sodium phosphate is used as a mild laxative
and in the treatment of hypophosphatemia.
Dibasic sodium phosphate is also used in food products; for
example as an emulsifier in processed cheese.
Safety
Dibasic sodium phosphate is widely used as an excipient in
parenteral, oral, and topical pharmaceutical formulations.
Phosphate occurs extensively in the body and is involved in
many physiological processes since it is the principal anion of
intracellular fluid. Most foods contain adequate amounts of
phosphate, making hypophosphatemia (phosphate deficiency)
virtually unknown except for certain disease states or in patients
receiving total parenteral nutrition. Treatment is usually by the oral
administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed
from the gastrointestinal tract, virtually all of it being excreted in the
urine, and the remainder is excreted in the feces.
Excessive administration of phosphate, particularly intravenously,
rectally, or in patients with renal failure, can cause
hyperphosphatemia that may lead to hypocalcemia or other severe
electrolyte imbalances. Adverse effects occur less frequently
following oral consumption, although phosphates act as mild saline
laxatives when administered orally or rectally. Consequently,
gastrointestinal disturbances including diarrhea, nausea, and
vomiting may occur following the use of dibasic sodium phosphate
as an excipient in oral formulations. However, the level of dibasic
sodium phosphate used as an excipient in a pharmaceutical
formulation is not usually associated with adverse effects.
LD50 (rat, oral): 17 g/kg
storage
The anhydrous form of dibasic sodium phosphate is hygroscopic.
When heated to 40℃, the dodecahydrate fuses; at 100℃ it loses its
water of crystallization; and at a dull-red heat (about 240℃) it is
converted into the pyrophosphate, Na4P2O7. Aqueous solutions of
dibasic sodium phosphate are stable and may be sterilized by
autoclaving.
The bulk material should be stored in an airtight container, in a
cool, dry place.
Incompatibilities
Dibasic sodium phosphate is incompatible with alkaloids, antipyrine, chloral hydrate, lead acetate, pyrogallol, resorcinol and calcium gluconate, and ciprofloxacin. Interaction between calcium and phosphate, leading to the formation of insoluble calcium-phosphate precipitates, is possible in parenteral admixtures.
Regulatory Status
GRAS listed. Accepted in Europe for use as a food additive. Included in the FDA Inactive Ingredients Database (injections; infusions; nasal, ophthalmic, oral, otic, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Disodium hydrogen phosphate dihydrate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Rishi Chemical Works Pvt Ltd | +91-3322290068 +91-3322290071 | Kolkata, India | 43 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Kronox Lab Sciences Pvt Ltd | +91-9313231074 +91-9313231074 | Gujarat, India | 240 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Pd Navkar Bio Chem Pvt Ltd | +91-8022157444 +91-8022157444 | Karnataka, India | 49 | 58 | Inquiry |
| Skc Chemie Pvt Ltd | +91-9820057869 +91-7400447421 | Maharashtra, India | 13 | 58 | Inquiry |
| Annexe Chem Pvt Ltd | +91-9724624061 +91-9898722162 | Gujarat, India | 57 | 58 | Inquiry |
| Nandu Chemical Industries | +91-8362330469 +91-8362330469 | Karnataka, India | 84 | 58 | Inquiry |
| Imperial Chem Incorporation (part of Imperial Group) | +91-9723609393 +91-9723609393 | Gujarat, India | 34 | 58 | Inquiry |
| S D Fine Chem Limited | +91-9323715856 +91-9323715856 | Maharashtra, India | 368 | 58 | Inquiry |
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