Methicillin Sodium Salt
- CAS No.
- 132-92-3
- Chemical Name:
- Methicillin Sodium Salt
- Synonyms
- meticillin sodium;Methicillin sodium;Sodium methicillin;Meticillin sodium salt;Methicillin sodium salt;METHICILLIN SODIUM USP/EP/BP;Methicillin Sodium Salt USP/EP/BP;Sodium (2,6-dimethoxyphenyl)penicillin;sodium 6-(2,6-dimethoxybenzamido)penicillanate;TIANFU-CHEM -sodium 6-(2,6-dimethoxybenzamido)penicillanate
- CBNumber:
- CB4874973
- Molecular Formula:
- C17H19N2NaO6S
- Molecular Weight:
- 402.39733
- MOL File:
- 132-92-3.mol
- Modify Date:
- 2023/6/8 9:02:49
| Melting point | 196-197℃ |
|---|---|
| Boiling point | 640℃ |
| Flash point | >110°(230°F) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | powder |
| color | white to off-white |
| Water Solubility | Slightly soluble in acetone. Soluble in ethanol or water |
| Sensitive | Light Sensitive |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H317-H319-H334-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-42/43 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | XH8950000 | |||||||||
| Toxicity | LD50 oral in mouse: > 4gm/kg | |||||||||
| NFPA 704 |
|
Methicillin Sodium Salt Chemical Properties,Uses,Production
Description
Methicillin is a semisynthetic penicillin antibiotic that can inhibit bacterial cell wall synthesis. It can be used to study methicillin-resistance in S. aureus.
Uses
Targets primarily the cell wall of Gram-positive organisms especially Staphylococcus aureus. Methicillin is used to study bacterium susceptibility, and to inhibit cell-wall synthesis. PBP's are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Methicillin Sodium Salt is inactivated by gastric acid so it is given to cells by other means in which gastric acid is not present in vitro.
Clinical Use
During 1960, methicillin sodium, 2,6-dimethoxyphenylpenicillinsodium (Staphcillin), the second penicillin produced asa result of the research that developed synthetic analogs, wasintroduced for medicinal use.
Methicillin sodium is particularly resistant to inactivationby the penicillinase found in staphylococci and somewhatmore resistant than penicillin G to penicillinase fromBacillus cereus.
Methicillin Sodium Salt Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21675 | 55 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | China | 9626 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |