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2-Bromo-5-chloro-1,3-difluorobenzene

2-Bromo-5-chloro-1,3-difluorobenzene Structure
CAS No.
883546-16-5
Chemical Name:
2-Bromo-5-chloro-1,3-difluorobenzene
Synonyms
4-Chloro-2,6-difluorobromobenzene;3,5-Difluoro-4-bromo-chlorobenzene;1-Bromo-4-chloro-2,6-difluorobenzene;4-Bromo-1-chloro-3,5-difluorobenzene;2-Bromo-5-chloro-1,3-difluorobenzene;Benzene, 2-broMo-5-chloro-1,3-difluoro-;2-Bromo-5-Chloro-1,3-Difluorobenzene,>98%;4-Bromo-1-chloro-3,5-difluorobenzene ISO 9001:2015 REACH;1-Bromo-4-chloro-2,6-difluorobenzene [4-Bromo-3,5-difluorochlorobenzen
CBNumber:
CB4971779
Molecular Formula:
C6H2BrClF2
Molecular Weight:
227.43
MOL File:
883546-16-5.mol
Modify Date:
2024/2/19 14:08:00

2-Bromo-5-chloro-1,3-difluorobenzene Properties

Boiling point 176℃
Density 1.805
Flash point 60℃
storage temp. Sealed in dry,Room Temperature

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HazardClass  IRRITANT
HS Code  2903998090

2-Bromo-5-chloro-1,3-difluorobenzene Chemical Properties,Uses,Production

Synthesis

2-Bromo-5-chloro-1,3-difluorobenzene is synthesised using 4-bromo-3,5-difluoroaniline as a raw material by chemical reaction. The specific synthesis steps are as follows:
4-bromo-3,5-difluoroaniline (25.0g, 117mmol), copper chloride (I) (23.1g, 230mmol) and copper chloride (II) (47.0g, 350mmol) in acetonitrile (150 mL) mixed solution in, it was added dropwise acetonitrile (50 mL) solution of isoamyl nitrite (49.0mL, 350mmol) at room temperature. After stirring for 4 hours at room temperature the mixture solution, poured into 2N hydrochloric acid (300mL), diethyl - ether (200m And extracted with L × 3). The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to obtain a crude product of a brown solid. By purifying this product by a silica gel column (hexane), 2-bromo-5-chloro-1,3-difluorobenzene as a yellow oil (21.4 g, yield: 81%) was obtained.
2-Bromo-5-chloro-1,3-difluorobenzene synthesis

Uses

2-Bromo-5-chloro-1,3-difluorobenzene is an organic intermediate that can be used to prepare other heterocyclic compounds as materials for organic electroluminescent devices.

2-Bromo-5-chloro-1,3-difluorobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-1-chloro-3,5-difluorobenzene 1-Bromo-4-chloro-2,6-difluorobenzene 4-Chloro-2,6-difluorobromobenzene Benzene, 2-broMo-5-chloro-1,3-difluoro- 1-Bromo-4-chloro-2,6-difluorobenzene [4-Bromo-3,5-difluorochlorobenzen 2-Bromo-5-Chloro-1,3-Difluorobenzene,>98% 3,5-Difluoro-4-bromo-chlorobenzene 4-Bromo-1-chloro-3,5-difluorobenzene ISO 9001:2015 REACH 2-Bromo-5-chloro-1,3-difluorobenzene 883546-16-5 C6H2F2BrCl Phenetole Fluorine series