Pentamidine isethionate
- CAS No.
- 140-64-7
- Chemical Name:
- Pentamidine isethionate
- Synonyms
- 2512RP;PentaM;M&B-800;RP-2512;LoMidin;Benambax;Aeropent;BanaMbax;NebuPent;P.P.-2512
- CBNumber:
- CB5101632
- Molecular Formula:
- C23H36N4O10S2
- Molecular Weight:
- 592.68
- MOL File:
- 140-64-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/5 17:53:06
| Melting point | 188-194 °C(lit.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | Freely soluble in water, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
| form | powder |
| color | White to Off-White |
| Merck | 13,7192 |
| Stability | Hygroscopic |
| InChIKey | YBVNFKZSMZGRAD-UHFFFAOYSA-N |
| CAS DataBase Reference | 140-64-7(CAS DataBase Reference) |
| EPA Substance Registry System | Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-[1,5-pentanediylbis(oxy)]bis[benzenecarboximidamide] (2:1) (140-64-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H317-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-43 |
| Safety Statements | 26-36/37 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | CV6500000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 2925294500 |
| Toxicity | LD50 intraperitoneal in mouse: 63mg/kg |
Pentamidine isethionate price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P0547 | Pentamidine isethionate salt powder | 140-64-7 | 25MG | ₹4351.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P0547 | Pentamidine isethionate salt powder | 140-64-7 | 100MG | ₹5434.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P0547 | Pentamidine isethionate salt powder | 140-64-7 | 250MG | ₹8389.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P0547 | Pentamidine isethionate salt powder | 140-64-7 | 1G | ₹16930.3 | 2022-06-14 | Buy |
Pentamidine isethionate Chemical Properties,Uses,Production
Chemical Properties
White or almost white powder or colourless crystals, hygroscopic.
Uses
Pentamidine isethionate salt has been used:
- as a positive control for anti-leishmanial, anti-plasmodial and cytotoxic assays
- as a prototypical compound to analyse the inhibitor effect on human ether-a-go-go-related gene (HERG) K+ channel trafficking
- as an anti-leishmanial agent in promastigotes
Definition
ChEBI: An organosulfonate salt obtained by reaction of pentamidine with two equivalents of 2-hydroxyethylsulfonic acid.
General Description
Odorless white or almost white crystals or powder. Odor also reported as a slight butyric odor. Very bitter taste. pH (5% aqueous solution) 4.5-6.5.
Air & Water Reactions
Hygroscopic. May be sensitive to prolonged exposure to air. Aqueous solutions deteriorate on storage. Water soluble.
Reactivity Profile
Can decompose on prolonged exposure to light.
Fire Hazard
Flash point data for Pentamidine isethionate are not available; however, Pentamidine isethionate is probably combustible.
Biological Activity
Antimicrobial. Neuroprotective; inhibits constitutive nitric oxide synthase in the brain and acts as a NMDA glutamate receptor antagonist.
Clinical Use
4,4’-(Pentamethylenedioxy)dibenzamidine diisethionate(NebuPent, Pentam 300) is a water-soluble crystalline saltthat is stable to light and air. The principal use of pentamidineis for the treatment of pneumonia caused by the opportunisticpathogenic protozoan P. carinii, a frequent secondaryinvader associated with AIDS. The drug may beadministered by slow intravenous infusion or by deep intramuscularinjection for PCP. An aerosol form of pentamidineis used by inhalation for the prevention of PCP inhigh-risk patients infected with HIV who have a previoushistory of PCP infection or a low peripheral CD4+ lymphocytecount.
Pentamidine has been used for the prophylaxis and treatmentof African trypanosomiasis. It also has some value fortreating visceral leishmaniasis. Pentamidine rapidly disappearsfrom the plasma after intravenous injection and is distributedto the tissues, where it is stored for a long period.This property probably contributes to the usefulness of thedrug as a prophylactic agent.
Pentamidine isethionate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
| EMCURE PHARMACEUTICALS LTD | +91 22 3061 0000 | New Delhi, India | 93 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12459 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29901 | 58 | Inquiry |
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