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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Structure
CAS No.
5428-80-8
Chemical Name:
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
Synonyms
Vacquinol-1;CS-2185;NSC13316;NSC-13316;NSC 13316;Vacquinol-1（NSC13316）;Vacquinol-1 dihydrochloride;NSC 13316;NSC13316;NSC-13316;VACQUINOL 1;VACQUINOL1;4-Quinolinemethanol,2-(4-chlorophenyl)-a-2-piperidinyl-;[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
CBNumber:
CB51254607
Molecular Formula:
C21H21ClN2O
Molecular Weight:
352.86
MOL File:
5428-80-8.mol
Modify Date:
2025/1/27 9:38:02
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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Properties

Melting point 198-199.5 °C
Boiling point 551.4±50.0 °C(Predicted)
Density 1.244±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.25 mg/ml
form A crystalline solid
pka 13.22±0.20(Predicted)
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H317-H319
Precautionary statements  P280-P305+P351+P338
HS Code  2933499090
NFPA 704
0
2 0

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Chemical Properties,Uses,Production

Description

Vacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture. A key effector of vacquinols is MAPK kinase 4 (MKK4). Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. It induces ATP depletion in glioblastoma cells (IC50 = 3.14 μM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics. Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.

Uses

Vacquinol-1 is in the vacquinol class of quinine derivatives that stimulate death in glioblastoma cells through massive macropinocytotic vacuolization, ATP depletion and eventual cytoplasmic membrane rupture.

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Preparation Products And Raw materials

Raw materials

Preparation Products

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Suppliers

Global( 80)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29808 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
TargetMol Chemicals Inc. United States 38630 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8467 58 Inquiry
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd +86-18341751992 +86-15382112998 China 892 58 Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd. +86-18621343501; +undefined18621343501 China 33338 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
TargetMol Chemicals Inc. 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 58
Shanghai Acmec Biochemical Technology Co., Ltd. 58

5428-80-8([2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol)Related Search:

Vanoxerine dihydrochloride Nintedanib Valspodar Vardenafil hydrochloride trihydrate Vandetanib
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol 4-Quinolinemethanol,2-(4-chlorophenyl)-a-2-piperidinyl- NSC 13316 NSC 13316;NSC13316;NSC-13316;VACQUINOL 1;VACQUINOL1 NSC13316 NSC-13316 CS-2185 4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl- Vacquinol-1 Vacquinol-1（NSC13316） Vacquinol-1 dihydrochloride 5428-80-8 C21H23Cl3N2O building block