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Vardenafil hydrochloride trihydrate

Vardenafil hydrochloride trihydrate Structure
CAS No.
330808-88-3
Chemical Name:
Vardenafil hydrochloride trihydrate
Synonyms
VARDENAFIL HYDROCHLORIDE TRIHYDRATE;Vardenafil hydrochloride CRS;Vardenafil for system suitability;Vardenafil Hydrochloride (1711010);vardenafil hydrochloride trihyrate;Verdenafil Hydrochloride Trihydrate;2-(2-ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride hydrate;2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride trihydrate;2-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one,hydrochloride, hydrate (1:1:3);IMidazo[5,1-f][1,2,4]triazin-4(1H)-one,2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-Methyl-7-propyl-,hydrochloride, hydrate (1:1:3)
CBNumber:
CB01230855
Molecular Formula:
C23H35ClN6O5S
Molecular Weight:
543.08
MOL File:
330808-88-3.mol
Modify Date:
2024/7/2 8:54:55
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Vardenafil hydrochloride trihydrate Properties

storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility ≥13.3 mg/mL in DMSO; ≥3.42 mg/mL in EtOH with gentle warming and ultrasonic; ≥95 mg/mL in H2O
form Solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H373
Precautionary statements  P260-P264-P270-P301+P310-P314-P405
RIDADR  UN 2811 6.1 / PGIII
HS Code  2933595960
NFPA 704
0
2 0

Vardenafil hydrochloride trihydrate price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PHR2720 Vardenafil Hydrochloride certified reference material, pharmaceutical secondary standard 330808-88-3 500MG ₹22700.03 2022-06-14 Buy
Product number Packaging Price Buy
PHR2720 500MG ₹22700.03 Buy

Vardenafil hydrochloride trihydrate Chemical Properties,Uses,Production

Description

Vardenafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50s = 0.2-1.2 nM) and PDE6 (IC50 = 2 nM). It is selective for PDE5 and PDE6 over PDE1 and PDE11 (IC50s = 230 and 130 nM, respectively). Vardenafil (4 mg/kg per day for three weeks) improves erectile function in a rat model of acute arteriogenic erectile dysfunction by increasing intracavernous pressure and mean arterial pressure, and this effect persists for at least two weeks following the end of treatment. Chronic vardenafil administration at a dose of 2 mg/kg for five weeks in subordinate mice reduces the latency to mount and increases the frequency of mounting behavior. Formulations containing vardenafil have been used in the treatment of erectile dysfunction.

Uses

Vardenafil hydrochloride trihydrate is a potent inhibitor of PDE5 (IC50 = 0.2-1.2 nM) that less effectively blocks the activities of PDE6, PDE1, and PDE11 (IC50s = 2, 230, and 130 nM, respectively). PDE5 inhibitors, including vardenafil, have applications in several conditions, including erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.[Cayman Chemical]

Vardenafil hydrochloride trihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Vardenafil hydrochloride trihydrate Suppliers

Global( 96)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
Macleods Pharmaceuticals Limited +91-2266762800 +91-2266762800 Maharashtra, India 116 58 Inquiry
Century Pharmaceuticals Ltd +91-2652361581 +91-2652361581 Gujarat, India 53 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Manus Aktteva Biopharma LLP +91 79 26463394 Gujarat, India 275 58 Inquiry
MACLEODS PHARMACEUTICALS LTD New Delhi, India 106 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Supplier Advantage
Ralington Pharma 58
Macleods Pharmaceuticals Limited 58
Century Pharmaceuticals Ltd 58
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Manus Aktteva Biopharma LLP 58
MACLEODS PHARMACEUTICALS LTD 58
SynZeal Research Pvt Ltd 58
Pharma Affiliates 58

Vardenafil hydrochloride trihydrate Spectrum

Vardenafil hydrochloride trihydrate(330808-88-3)1HNMR

330808-88-3(Vardenafil hydrochloride trihydrate)Related Search:

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IMidazo[5,1-f][1,2,4]triazin-4(1H)-one,2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-Methyl-7-propyl-,hydrochloride, hydrate (1:1:3) Vardenafil for system suitability Verdenafil Hydrochloride Trihydrate Vardenafil hydrochloride CRS 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride trihydrate vardenafil hydrochloride trihyrate Vardenafil Hydrochloride TrihydrateQ: What is Vardenafil Hydrochloride Trihydrate Q: What is the CAS Number of Vardenafil Hydrochloride Trihydrate Q: What is the storage condition of Vardenafil Hydrochloride Trihydrate Vardenafil Hydrochloride (1711010) 2-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one,hydrochloride, hydrate (1:1:3) VARDENAFIL HYDROCHLORIDE TRIHYDRATE 2-(2-ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride hydrate 330808-88-3