camalexin
- CAS No.
- 135531-86-1
- Chemical Name:
- camalexin
- Synonyms
- camalexin;Camalexine;Camalexin >=98% (HPLC);2-(1H-indol-3-yl)thiazole;3-(Thiazol-2-yl)-1H-indole;1H-Indole, 3-(2-thiazolyl)-;2-(1H-indol-3-yl)-1,3-thiazole;3-(1,3-Thiazol-2-yl)-1H-indole;3-(1,3-Thiazol-2-yl)-1H-indole, camalexin;Phytoalexin,antifungal,Camalexin,antiproliferative,Bacterial,anticancer,ROS,Fungal,Inhibitor,Reactive Oxygen Species,inhibit,antibacterial,cruciferous
- CBNumber:
- CB51384054
- Molecular Formula:
- C11H8N2S
- Molecular Weight:
- 200.26
- MOL File:
- 135531-86-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/20 16:43:00
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
camalexin price More Price(2)
camalexin Chemical Properties,Uses,Production
Description
Camalexin is an alkaloid released by plants of the Brassicaceae family in response to pathogen infection. In addition to antimicrobial properties and a role in plant defense, camalexin exhibits antiproliferative activity in vitro against various cancer cell lines. Camalexin is active against HeLa, Jurkat, MDA-MB-231, and CEM cancer cell lines (IC50s = 50.0, 46.2, 77.7, and 67.6 μM, respectively), but it is also toxic to primary human umbilical vein endothelial cells (HUVEC; (IC50 = 74.0 μM). Camalexin induces apoptosis in Jurkat cells by increasing reactive oxygen species (ROS) levels and activating caspase-8 and caspase-9. In human prostate cancer cell lines, camalexin (25 μM) is more active against aggressive lines and increases ROS levels and apoptosis via cathepsin D relocation from lysosomes to the cytosol.
Uses
Camalexin has been used in quantification and tolerance assays in Arabidopsis thaliana leaves.
Definition
ChEBI: An indole phytoalexin that is indole substituted at position 3 by a 1,3-thiazol-2-yl group.
camalexin Preparation Products And Raw materials
camalexin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Hebei Weibang Biotechnology Co., Ltd | +8615350571055 | China | 5848 | 58 | Inquiry |
| Guangzhou Younan Technology Co., Ltd | 020-020-82000279 18988968278 | China | 4297 | 58 | Inquiry |
| Huanuo Pharmaceutical Technology (Guangxi) Co., Ltd | 13005928603 | China | 6788 | 58 | Inquiry |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | China | 4182 | 55 | Inquiry |