Olodaterol

CAS No.: 868049-49-4

Chemical Name:: Olodaterol

Synonyms: Olodaterol free base;Odaro;BI-1744;Striverdi;Olodaterol;OLODATEROL D3;BI 1744(Olodaterol;Striverdi Respimat);Olodaterol USP/EP/BP;Olodaterol ImpurityＡ

CBNumber:: CB52484977

Molecular Formula:: C21H26N2O5

Molecular Weight:: 386.44

MOL File:: 868049-49-4.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:11

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Olodaterol Properties

Boiling point	649.0±55.0 °C(Predicted)
Density	1.250
solubility	DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml; DMSO: 15 mg/ml; Ethanol: 1 mg/ml
form	A crystalline solid
pka	9.42±0.20(Predicted)
color	Light yellow to khaki
Stability	Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Danger

Hazard statements

H302-H319-H372

Precautionary statements

P264-P280-P305+P351+P338-P337+P313P-P260-P264-P270-P314-P501-P264-P270-P301+P312-P330-P501

NFPA 704

	0
2		0

Olodaterol Chemical Properties,Uses,Production

Description

In 2013, olodaterol (also known BI-1744 CL) was approved for the treatment of chronic obstructive pulmonary disease (COPD) in Russia (March), Canada (June), and the EuropeanUnion (October). Olodaterol is delivered via the Respimat? Soft Mist? inhaler. Olodaterol was discovered from an effort to identify a β2-adrenergic receptor agonist that could be given once daily and with a superior safety profile over known β2- adrenergic receptor agonists. Olodaterol is a potent β2 agonist (EC₅₀=0.1 nM, intrinsic activity=88%) and is highly selective for the β2 receptor over β1 and β3 receptors. In preclinical models in guinea pigs and dogs, olodaterol had a rapid onset of action and provided bronchoprotection over 24 h. Mechanistic studies indicated that olodaterol forms a highly stable complex with the β2-adrenergic receptor, with a dissociation half-life of 17.8 h. The synthesis of olodaterol proceeds through an (R)-styrene epoxide that is prepared via enantioselective reduction of an α-chloroketone intermediate. Ring opening of the epoxide with 1-(4- methoxyphenyl)-2-methylpropan-2-amine provides olodaterol.

Definition

ChEBI: A member of the class of benzoxazine that is 6-hydroxy-1,4-benzoxazin-3-one in which the hydrogen at position 4 is replaced by a (1R)-1-hydroxy-2-{[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino}ethyl group. Used (as its hydrochloride salt) for long-term treatment of airflow obstruction in patients with chronic obstructive pulmonary disease including chronic bronchitis and/or emphysema.

Olodaterol Preparation Products And Raw materials

Raw materials

8-[(1R)-1-Hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-6-(phenylmethoxy)-2H-1,4-benzoxazin-3(4H)-one 6-benzyloxy-8-((R)-2-chloro-1-hydroxy-ethyl)-4H-benzo[1,4]-oxazin-3-one

Preparation Products

Olodaterol Suppliers

Global( 95)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6739	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6754	58	Inquiry
Hebei Yanxi Chemical Co., Ltd.	+8617531153977	China	5855	58	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	China	19910	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32965	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29871	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39894	58	Inquiry
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	China	9310	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
Hebei Yanxi Chemical Co., Ltd.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Baoji Guokang Bio-Technology Co., Ltd.	58

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6-Hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one 2H-1,4-Benzoxazin-3(4H)-one, 6-hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]- BI 1744(Olodaterol Striverdi Respimat) Olodaterol Olodaterol ImpurityＡ　 BI-1744 Striverdi Olodaterol, 98%, a long acting β2-adrenoceptor agonist OLODATEROL;BI-1744;STRIVERDI Olodaterol, 6-Hydroxy-8-[(1r)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2h-1,4-benzoxazin-3(4h)-one STRIVERDI RESPIMAT; BI 1744; BI1744 (R)-6-hydroxy-8-(1-hydroxy-2-((1-(4-methoxyphenyl)-2-methylpropan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 6 - hydroxy - 8 - [(1 r) - 1 - hydroxy - 2 - [[2 - (4 - methoxy phenyl) - 1, 1-2 methyl ethyl] amino] ethyl] - 2 h - 1, 4 - benzo oxazine - 3 (4 h) - one Olodaterol USP/EP/BP Olodaterol Discontinued OLODATEROL D3 Olodaterol D3 HydrochlorideQ: What is Olodaterol D3 Hydrochloride Q: What is the CAS Number of Olodaterol D3 Hydrochloride Q: What are the applications of Olodaterol D3 Hydrochloride Olodaterol free base 6-hydroxy-8-(1-hydroxy-2-((2-(4-methoxyphenyl)-1,1-dimethylethyl)amino)ethyl)-2H-1,4-benzoxazin-3(4H)-one Odaro 868049-49-4