5-Methyl-3,4-diphenylisoxazole
- CAS No.
- 37928-17-9
- Chemical Name:
- 5-Methyl-3,4-diphenylisoxazole
- Synonyms
- 5-Methyl-3;CAS:37928-17-9;Parecoxib Sodium-4;5-Methyl-3,4-diphenyl;Parecoxib Related Compound;5-Methyl-3,4-diphenylisoxazole;3,4-Diphenyl-5-methylisoxazole;Parecoxib SodiuM iMpurity PR-SM;Parecoxib SodiuM interMediate A;Isoxazole, 5-Methyl-3,4-diphenyl-
- CBNumber:
- CB52604537
- Molecular Formula:
- C16H13NO
- Molecular Weight:
- 235.28
- MOL File:
- 37928-17-9.mol
- Modify Date:
- 2025/4/7 17:19:15
| Melting point | 96.0 to 100.0 °C |
|---|---|
| Boiling point | 340.1±21.0 °C(Predicted) |
| Density | 1.108±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | -2.53±0.50(Predicted) |
| color | White to Off-White |
| InChIKey | ZXIRUKJWLADSJS-UHFFFAOYSA-N |
5-Methyl-3,4-diphenylisoxazole price More Price(2)
5-Methyl-3,4-diphenylisoxazole Chemical Properties,Uses,Production
Uses
5-Methyl-3,4-diphenylisoxazole is synthesis The key intermediate of Parecoxib Sodium (Parecoxib Sodium).Parecoxib Sodium is by the Pfizer of the U.S. The cox 2 inhibitor of company's research and development, listed in European Union in 2002, trade name Dynastat, is used for The short term therapy of postoperative pain.
Synthesis
In four mouthfuls of round-bottomed flasks of a 1L add compound 2 (40g), methanol (400mL), 7.7% Aqueous sodium carbonate (400mL), is heated to 70 DEG C, after stirring reaction 2h, and TLC plate monitoring raw material Fundamental reaction is complete, and solution is divided into solid-liquid biphase, is extracted with ethyl acetate, collected organic layer, with anhydrous Sodium sulfate is dried, and vacuum obtains white solid, HPLC purity: 94.9% after being spin-dried for.White solid uses 40ml ethyl acetate and the mixed solvent recrystallization of 120ml normal hexane (1:3) again, Obtaining target compound is white solid 34.2g, yield 92%, HPLC purity: 99.7%.m.p.97-98??￡? MS(m/z):236(M+H)+￡?1H NMR(400MHz,CDCl3) |?:2.43(s,3H,-CH3), 7.19-7.43 (m, 10H ,-CH=).
5-Methyl-3,4-diphenylisoxazole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1817 | 58 | Inquiry |
| Aruvi Labs | +91-8056181939 +91-8056181939 | Tamil Nadu, India | 149 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| Shivam Pharma Chemicals | 91-22-26403900 | Maharashtra, India | 656 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6514 | 58 | Inquiry |
| Aruvi Labs | 91-0-8056181939 | Tamil Nadu, India | 68 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | CHINA | 1319 | 58 | Inquiry |
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