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ChemicalBook > Product Catalog >API >Antipyretic analgesics >Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) >PARECOXIB SODIUM

PARECOXIB SODIUM

PARECOXIB SODIUM Structure
CAS No.
198470-85-8
Chemical Name:
PARECOXIB SODIUM
Synonyms
Dynastat;Rayzon;SC 69124A;Parecoxib CRS;parexib sodium;Parecoxib-011-Na;Parecoxib sodium;Parecoxib sodiuM sal;Parecoxib sodiuM salt;Parecoxib Impurity 64
CBNumber:
CB21003464
Molecular Formula:
C19H19N2NaO4S
Molecular Weight:
394.42
MOL File:
198470-85-8.mol
MSDS File:
SDS
Modify Date:
2024/9/20 17:27:21
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PARECOXIB SODIUM Properties

Melting point 273-275°C
storage temp. Inert atmosphere,2-8°C
solubility DMF: 10mg/mL; DMSO: 15mg/mL; Ethanol: 3mg/mL; PBS (pH 7.2): 5mg/mL
form Powder
color White to off-white
InChI InChI=1S/C19H18N2O4S.Na.H/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;;/h4-12H,3H2,1-2H3,(H,21,22);;
InChIKey OGSQVUBPCQXSGW-UHFFFAOYSA-N
SMILES CC1ON=C(C2C=CC=CC=2)C=1C1C=CC(S(=O)(=O)NC(=O)CC)=CC=1.[NaH]

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

PARECOXIB SODIUM Chemical Properties,Uses,Production

Description

Parecoxib is a prodrug form of the COX-2 inhibitor valdecoxib . It is converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys. Parecoxib is also a cannabinoid (CB) receptor 1 agonist with an EC50 value of 2.4 μM in HEK293 cells. It reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg).

Chemical Properties

White Solid

Uses

Anti-inflammatory, analgesic.

Indications

For the short-term treatment of acute pain and post-operative pain i.e., oral surgery, abdominal hysterectomy, myomectomy, total knee replacement, total hip arthroplasty, laparoscopic cholecystectomy, inguinal hernia repair and other general surgery like diagnostic laparoscopy, gastrectomy, hernioplasty, appendectomy, hemithyroidectomy and splenectomy. Parecoxib Sodium may be used pre-operatively to prevent or reduce post-operative pain and it can reduce opioid requirements when they are used concomitantly.

Application

Parecoxib sodium is a water-soluble sodium salt of the amide prodrug of valdecoxib. Parecoxibundergoes enzymatic hydrolysis in vivo to the active moiety valdecoxib, and is formulated as apowder for solution for parenteral administration. Valdecoxib is a selective inhibitor of the enzymeCOX-2.

Biological Functions

A water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation.

Pharmacokinetics

Parecoxib (Dynastat) is a prodrug of valdecoxib. Valdecoxib is an NSAID that exhibits antiinflammatory, analgesic and antipyretic properties in animal models. The mechanism of action is believed to be due to inhibition of prostaglandin synthesis primarily through inhibition of COX-2. At therapeutic plasma concentrations in humans valdecoxib does not inhibit cyclooxygenase-1 (COX-1).

PARECOXIB SODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

PARECOXIB SODIUM Suppliers

Global( 391)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Hetero Drugs Limited +91-4023704923 +91-4023704923 Telangana, India 296 58 Inquiry
Nuray Chemicals Pvt Ltd +91-4066616700 +91-8220444745 Tamil Nadu, India 49 58 Inquiry
Aruvi Labs +91-8056181939 +91-8056181939 Tamil Nadu, India 149 58 Inquiry
Lifecare Laboratories Pvt. Ltd +91-4023750123 +91-4023750123 Hyderabad, India 18 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Aegis Pharma Chem 08048372414Ext 752 Mumbai, India 2 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
S. Zhaveri Pharmakem Pvt. Ltd 91-22-43676666 Maharashtra, India 112 58 Inquiry
Vedan Healthcare 91-9930585828 Maharashtra, India 39 58 Inquiry
Supplier Advantage
Hetero Drugs Limited 58
Nuray Chemicals Pvt Ltd 58
Aruvi Labs 58
Lifecare Laboratories Pvt. Ltd 58
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
Aegis Pharma Chem 58
SynZeal Research Pvt Ltd 58
S. Zhaveri Pharmakem Pvt. Ltd 58
Vedan Healthcare 58

PARECOXIB SODIUM Spectrum

PARECOXIB SODIUM(198470-85-8)1HNMR

198470-85-8(PARECOXIB SODIUM)Related Search:

N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)isobutyraMide 5-Methyl-3-phenyl-4-(phenylMethyl)isoxazole Valdecoxib 3'-Sulfonyl Chloride IMpurity 5-METHYL-3,4-DIPHENYL-4,5-DIHYDROISOXAZOL-5-OL 3-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonaMide
4-(4-chlorophenyl)-5-methyl-3-phenylisoxazole 2-Phenylacetophenone Valdecoxib IMpurity B Pantoprazole Sodium Paliperidone Z-Oxime
4-(3-methyl-4-phenylisoxazol-5-yl)benzenesulfonamide ethyl 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonate 5-Methyl-3,4-diphenylisoxazole DeoxyBenzoinOxime Valdecoxib 3'-SulfonaMide IMpurity
Parecoxib Impurity H Parecoxib Valdecoxib
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N-[4-(5-METHYL-3-PHENYLISOXAZOL-4-YL)PHENYLSULFONYL]PROPIONAMIDE, SODIUM SALT Parecoxib sodiuM salt N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanaMide SodiuM Salt Rayzon SC 69124A PropanaMide,N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-, sodiuM salt (1:1) Parecoxib sodiuM cloth Parecoxib sodium N-[4-(5-Methyl-3-phenylisoxazol-4-yl)phenylsulfonyl]propionamide sodium salt Parecoxib Sodium Impurity Parecoxib sodiuM sal Parecoxib sodium （Intermediate in China ONLY） sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide Parecoxib-011-Na Parecoxib Impurity 64 PARECOXIB SODIUM USP/EP/BP sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonysodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl) (propionyl)amidel) (propionyl)amide N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide Sodium Salt（Parecoxib Sodium） Dynastat N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonyl]propanamide sodium hydride Parecoxib sodium Parecoxib Impurity 22 Sodium Salt Parecoxib CRS parexib sodium Parecoxib Impurity 11 Sodium Salt 198470-85-8 98470-85-8 198470-85-5 10.98470-85-8 C19H17N2NaO4S C19H17N2O4SNa C19H18N2O4SNa Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals 198470-85-8