Pantoprazole Sodium
- CAS No.
- 138786-67-1
- Chemical Name:
- Pantoprazole Sodium
- Synonyms
- PANTOZOL;Pantoloc;Protonix;Pantoprazol Sodium;Zurcal;Nolpaza;PANTECTA;EUPANTOL;Controloc;midazolesodium
- CBNumber:
- CB0415897
- Molecular Formula:
- C16H14F2N3NaO4S
- Molecular Weight:
- 405.35
- MOL File:
- 138786-67-1.mol
- Modify Date:
- 2024/11/17 16:00:36
| Melting point | 199-202°C |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly) |
| form | Solid |
| color | White to Pale Beige |
| Stability | Hygroscopic |
| InChI | InChI=1S/C16H14F2N3O4S.Na/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;/h3-7,15H,8H2,1-2H3;/q-1;+1 |
| InChIKey | YNWDKZIIWCEDEE-UHFFFAOYSA-N |
| SMILES | C12C=C(C=CC=1N(C(S(=O)CC1N=CC=C(OC)C=1OC)=N2)[Na])OC(F)F |
| CAS DataBase Reference | 138786-67-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-37/38-41-48 |
| Safety Statements | 22-26-36/37/39-45 |
Pantoprazole Sodium Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
General Description
Pantoprazole sodium, racemicsodium5-(difluoromethoxy)-2-[[3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sesquihydrate is a white tooff-white crystalline powder that is freely soluble in water,very slightly soluble in phosphate buffer at pH 7.4, and practicallyinsoluble in n-hexane. The benzimidazole of this drughas a weakly basic nitrogen (pyridine N, pKa 3.83) and an benzimidazoleproton (pKa 0.11), facilitating formulation as asodium salt. The stability of the compound in aqueous solutionis pH dependent; the rate of degradation increases with decreasingpH. At ambient temperature, the degradation half-lifeis approximately 2.8 hours at pH 5.0 and approximately 220hours at pH 7.8.
The absorption of pantoprazole is rapid (Cmax of2.5μg/mL, Tmax 2.5 hours) after single or multiple oral40-mg doses. Pantoprazole is well absorbed (77% bioavailability).Administration with food may delay its absorptionbut does not alter pantoprazole bioavailability. Pantoprazoleis distributed mainly in extracellular fluid. The serum proteinbinding of pantoprazole is about 98%, primarily to albumin.Pantoprazole is extensively metabolized in the liver throughthe CYP system, including O-demethylation (CYP2C19),with subsequent sulfation. Other metabolic pathways includesulfur oxidation by CYP3A4. There is no evidencethat any of the pantoprazole metabolites have significantpharmacological activity. Approximately 71% of a dose of pantoprazole is excreted in the urine, with 18% excretedin the feces through biliary excretion.
Pantoprazole Sodium Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| NB Healthcare Pvt Ltd | +91 7227055467 | Gujarat, India | 37 | 58 | Inquiry |
| THE MOLECULEZ | +91-7506703683 +91-7506703683 | Maharashtra, India | 79 | 58 | Inquiry |
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| Chynops Pharma | +919998000404 | Gujarat, India | 39 | 58 | Inquiry |
| Shree HariKrishna Pharmaceuticals | +91-9925611910 +91-9925611910 | Gujarat, India | 16 | 58 | Inquiry |
| SOLISOM HEALTHCARE LLP | +918160916499 | Gujarat, India | 14 | 58 | Inquiry |
| Chemeca Drugs Private Limited (Vegesna Laboratories Pvt Ltd) | +91-8924236065 +91-9951616502 | AndhraPradesh, India | 48 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Macleods Pharmaceuticals Limited | +91-2266762800 +91-2266762800 | Maharashtra, India | 116 | 58 | Inquiry |
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