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Cimetidine

Cimetidine Structure
CAS No.
51481-61-9
Chemical Name:
Cimetidine
Synonyms
CIMITIDINE;TAGAMET;CIMETIDINE A;CIMETIDINE USP;1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine;Cimal;Notul;Ulhys;Peptol;Tratul
CBNumber:
CB4229414
Molecular Formula:
C10H16N6S
Molecular Weight:
252.34
MOL File:
51481-61-9.mol
Modify Date:
2024/7/24 17:31:20
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Cimetidine Properties

Melting point 139-144°C
Boiling point 476.2±55.0 °C(Predicted)
Density 1.2583 (rough estimate)
refractive index 1.5700 (estimate)
storage temp. 2-8°C
solubility Slightly soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute mineral acids.
form Solid
pka pKa 6.80 (Uncertain)
color White to Off-White
Water Solubility 0.5 g/100 mL at 20 ºC
Merck 14,2279
InChIKey AQIXAKUUQRKLND-UHFFFAOYSA-N
CAS DataBase Reference 51481-61-9(CAS DataBase Reference)
NIST Chemistry Reference Cimetidine(51481-61-9)
IARC 3 (Vol. 50) 1990
EPA Substance Registry System Guanidine, N-cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]- (51481-61-9)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H303-H360
Precautionary statements  P202-P405-P501a-P201-P280-P308+P313
Hazard Codes  T,Xn
Risk Statements  60-42/43-36/37/38-20/22
Safety Statements  53-26-36/37/39-45-36-22
WGK Germany  3
RTECS  MF0035500
HS Code  29339900
Toxicity LD50 in mice, rats (mg/kg): 2600, 5000 orally; 150, 106 i.v.; 470, 650 i.p. (Brimblecombe)
NFPA 704
0
3 0

Cimetidine price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) C4522 Cimetidine 51481-61-9 5G ₹8573.4 2022-06-14 Buy
Sigma-Aldrich(India) C4522 Cimetidine 51481-61-9 10G ₹14083.33 2022-06-14 Buy
Sigma-Aldrich(India) PHR1075 Cimetidine Pharmaceutical Secondary Standard; Certified Reference Material 51481-61-9 1G ₹8356.9 2022-06-14 Buy
Sigma-Aldrich(India) C4522 Cimetidine 51481-61-9 25G ₹27603.75 2022-06-14 Buy
TCI Chemicals (India) C1252 Cimetidine 51481-61-9 25G ₹12900 2022-05-26 Buy
Product number Packaging Price Buy
C4522 5G ₹8573.4 Buy
C4522 10G ₹14083.33 Buy
PHR1075 1G ₹8356.9 Buy
C4522 25G ₹27603.75 Buy
C1252 25G ₹12900 Buy

Cimetidine Chemical Properties,Uses,Production

Description

Cimetidine is a representative of first-generation antihistamine drugs that block H2 receptors.

Chemical Properties

White Solid

Uses

Cimetidine is used for treating ulcer problems of the stomach and duodenum and for other conditions accompanied by an elevation of acidity and excess secretion of gastric juice. It is used for preventing injuries and the blood flow of the upper regions of the gastrointestinal tract.

Definition

ChEBI: A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H -receptor antagonist that inhibits the production of acid in stomach.

Indications

Cimetidine, the first released H2-blocker, like histamine, contains an imidazole ring structure. It is well absorbed following oral administration, with peak blood levels 45 to 90 minutes after drug ingestion. Blood levels remain within therapeutic concentrations for approximately 4 hours after a 300-mg dose. Following oral administration, 50 to 75% of the parent compound is excreted unchanged in the urine; the rest appears primarily as the sulfoxide metabolite.

General Description

White crystals with a slight sulfur-mercaptan odor.

Air & Water Reactions

Slightly water soluble.

Fire Hazard

Flash point data for Cimetidine are not available. Cimetidine is probably combustible.

Biological Activity

Widely used H 2 histamine antagonist which has more recently been described as an inverse agonist. Also a potent I 1 imidazoline binding site ligand.

Pharmacology

The main pharmacological effect of cimetidine is the suppression of gastric juice secretion associated with H2 receptors of the stomach walls. It suppresses both basal and stimulated hydrochloric acid produced by food as well as histamine and gastrine, which simultaneously lower pepsin activity.

Side effects

Cimetidine may infrequently cause diarrhea, nausea, vomiting, or mental confusion. A rare association with granulocytopenia, thrombocytopenia, and pancytopenia has been reported. Gynecomastia has been demonstrated in patients receiving either high-dose or long-term therapy.

Cimetidine Preparation Products And Raw materials

Raw materials

Potassium carbonate 4-Methylimidazole S,S'-Dimethyl dithiocarbonate Ethyl chloroacetate Methylamine
Potassium hydroxide
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Preparation Products

Cimetidine Suppliers

Global( 626)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
BTC pharm India +918790379245 AndhraPradesh, India 1269 58 Inquiry
Medi Pharma Drug House +919930911911 Mumbai, India 143 58 Inquiry
SMS Lifesciences India Ltd (MAHI Drugs Pvt Ltd) +91-40-66288888 +91-8374455507 Telangana, India 23 58 Inquiry
Vivimed Labs Ltd +914066086608 Telangana, India 61 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pavak Trade Link 08048372113Ext 422 Mumbai, India 1 58 Inquiry
Supplier Advantage
BTC pharm India 58
Medi Pharma Drug House 58
SMS Lifesciences India Ltd (MAHI Drugs Pvt Ltd) 58
Vivimed Labs Ltd 58
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
TCI Chemicals (India) Pvt. Ltd. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
Pavak Trade Link 58

Related articles

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Cimetidine Spectrum

Cimetidine(51481-61-9)MSCimetidine(51481-61-9)1HNMRCimetidine(51481-61-9)IR1Cimetidine(51481-61-9)IR2Cimetidine(51481-61-9)Raman

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SKF-92334 N-CYANO-N'-METHYL-N''-[[2-[(5-METHYL-1H-IMIDAZOL-4-YL)METHYL]THIO]ETHYL]GUANIDINE Cimetidine (base and/or unspecified salts) Peptol Tametin Tratul Ulcedin Ulcedine Ulcimet CIMETIDINE(RG) Acibilin Acinil Cimal Cimetag Cimetum Dyspamet Edalene Eureceptor FPF 1002 fpf1002 Gastromet Guanidine, N''-cyano-N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]- Guanidine, N-cyano-N'-methyl-N''-[2-[[5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]- guanidine,n-cyano-n’-methyl-n’’-(2-(((5-methyl-1h-imidazol-4-yl)methyl)thio)e guanidine,n-cyano-n’-methyl-n’’-(2-(((5-methyl-1h-imidazol-4-yl)methyl)thio)et guanidine,n-cyano-n’-methyl-n’’-[2-[[(5-methyl-1h-imidazol-4-yl)methyl]thio]et metracin n-cyano-n’-methyl-n’’-(2-(((5-methyl-1h-imidazol-4-yl)methyl)thio)ethyl)guan n-cyano-n’-methyl-n’’-(2-(((5-methyl-1h-imidazol-4-yl)methyl)thio)ethyl)guanid N-Cyano-N'-methyl-N''-((E)-2-([(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl)ethyl)guanidine 3-cyano-1-Methyl-2-(2-{[(4-Methyl-1H-iMidazol-5-yl)Methyl]sulfanyl}ethyl)guanidine NSC 335308 Ulcerex Histodil N-Cyano-N'-methyl-N''-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]-guanidine Acibilin：Acinil Aciloc Biomag Brumetidina N-Cyano-N’-methyl-N’’-[2-[[(5-methyl-1H-imidazol-4-y1)methyl]thio]ethyl]guanidine Notul UlcofMk Uleedin Uleerfen 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylthio]ethyl]guanidine Cimetidine (free base) Cimetidine,SKF-92334 Cimetidine (200 mg) Cimetidine, 250 mg CIMETIDINE(P) Ulcofalk Ulcomedina Ulcomet Ulhys valmagen venopex CIMITIDINE TYPE A/AB Cimetidine USP BP DAB