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Sitagliptin

Sitagliptin Structure
CAS No.
486460-32-6
Chemical Name:
Sitagliptin
Synonyms
Sitagliptin base;(3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;(R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;Janumet;Sitagliptin free base;Sitagliptin API;Sitagliptin-D4;Unii-qfp0p1dv7z;1,2,4-Triazolo(4,3-A)pyrazine, 7-((3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl)-5,6,7,8-tetrahydor-3-(trifluoromethyl)-;1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)-
CBNumber:
CB01449778
Molecular Formula:
C16H15F6N5O
Molecular Weight:
407.31
MOL File:
486460-32-6.mol
MSDS File:
SDS
Modify Date:
2024/7/24 13:33:21
Request For Quotation

Sitagliptin Properties

Melting point 114.1-115.7 °C
Boiling point 529.9±60.0 °C(Predicted)
Density 1.61±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 50 mg/mL (122.76 mM)
form Solid
pka 7.20±0.10(Predicted)
color White to off-white
InChI InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
InChIKey MFFMDFFZMYYVKS-SECBINFHSA-N
SMILES C(N1CCN2C(C(F)(F)F)=NN=C2C1)(=O)C[C@H](N)CC1=CC(F)=C(F)C=C1F
CAS DataBase Reference 486460-32-6(CAS DataBase Reference)
EPA Substance Registry System 1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)- (486460-32-6)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

Sitagliptin Chemical Properties,Uses,Production

Description

Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is a first-in-class oral drug launched for the treatment of type 2 diabetes. It acts by slowing the inactivation of incretins, which are endogenous peptides involved in the physiologic regulation of glucose homeostasis. Incretin hormones, including glucagonlike peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. When blood glucose concentrations are normal or elevated,GLP-1 and GIP increase the synthesis and release of insulin from pancreatic b cells via intracellular signaling pathways involving cAMP. GLP-1 also lowers glucagon secretion from pancreatic αcells, which leads to reduced hepatic glucose production.

Uses

Labeled Sitagliptin , intended for use as an internal standard for the quantification of Sitagliptin by GC- or LC-mass spectrometry.

Definition

ChEBI: Sitagliptin is a triazolopyrazine that exhibits hypoglycemic activity. It has a role as a serine proteinase inhibitor, a hypoglycemic agent, an EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor, an environmental contaminant and a xenobiotic. It is a triazolopyrazine and a trifluorobenzene.

Sitagliptin Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-3-Amino-1-(3-(Trifluoromethyl)-5,6-Dihydro-[1,2,4] Triazolo[4,3-A]Pyrazin-7(8H)-Yl)-4-(2,4,5-Trifluorophenyl) Butan-1-One Mandelate(Sgn06M)

Sitagliptin Suppliers

Global( 508)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Jigs Chemical ltd +919099003427 Gujarat, India 239 58 Inquiry
Cadila Pharmaceuticals Ltd +91-7069076657 +91-7069076657 Ahmedabad, India 54 58 Inquiry
HEMA PHARMACEUTICALS PVT LTD +91-9537936912 +91-9537936912 Gujarat, India 48 58 Inquiry
SGMR PHARMACEUTICALS PVT LTD +91-9032001889 +91-9032001889 Telangana, India 83 58 Inquiry
Bulat Pharmaceutical Pvt Ltd +91-8448085659 +91-8448085660 Haryana, India 123 58 Inquiry
Bhausa Life Sciences +91-8154986830 +91-8154986830 Gujarat, India 201 58 Inquiry
Lofty labs +91-7673920392 +91-7673920392 Telangana, India 32 58 Inquiry
Lupin Ltd +91-8019896181 +91-8019896181 Maharashtra, India 93 58 Inquiry
Glenmark Pharmaceuticals Limited +912240189999 Maharashtra, India 93 58 Inquiry
FDC Limited +912226782653 Mumbai, India 30 58 Inquiry
Supplier Advantage
Jigs Chemical ltd 58
Cadila Pharmaceuticals Ltd 58
HEMA PHARMACEUTICALS PVT LTD 58
SGMR PHARMACEUTICALS PVT LTD 58
Bulat Pharmaceutical Pvt Ltd 58
Bhausa Life Sciences 58
Lofty labs 58
Lupin Ltd 58
Glenmark Pharmaceuticals Limited 58
FDC Limited 58

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Sitagliptin Spectrum

Sitagliptin(486460-32-6)1HNMR

486460-32-6(Sitagliptin)Related Search:

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Sitafloxacin 6-Aminocaproic acid Cilostazol Doxazosin 3-Aminophenol
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Sitagliptin (3R)-3-AMino-1-[3-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,2,4-riazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-rifluorophenyl) butan-1-one Sitagliptin-D4 HCL Hsdb 7516 C53323300 Metformin / sitagliptin Metformin hydrochloride mixture with sitagliptin phosphate Metformin mixture with sitagliptin Tadalafil and its interMediate Sitaglipitin (S)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one CS-282 Sitagliptin (Metformin,MK-0431) (790712-60-6) sitagliptin Siglitatin Sitag 1,2,4-Triazolo[4,3-a]pyrazine,7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)- SitagL Sitagliptin USP/EP/BP Sitaglitpin base (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one (Sitagliptin Impurity) (3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one Sitagliptin BaseQ: What is Sitagliptin Base Q: What is the CAS Number of Sitagliptin Base Q: What is the storage condition of Sitagliptin Base (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one (R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one Sitagliptin (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one Sitagliptin base Sitagliptin-D4 1,2,4-Triazolo(4,3-A)pyrazine, 7-((3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl)-5,6,7,8-tetrahydor-3-(trifluoromethyl)- Janumet Unii-qfp0p1dv7z Sitagliptin API 1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)- Sitagliptin free base SIT-BASE N-Methyl-L-alanine 3913-67-5 Trimethoprim Impurity 54 486460-32-6 1011232-08-8 C16H15F6N5O Heterocycles Pharmaceutical intermediate API 486460-32-6