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Cilastatin

CAS No.: 82009-34-5

Chemical Name:: Cilastatin

Synonyms: Cilastatin acid;Cilastatin AMMoniuM Salt;(Z)-7-(((R)-2-Amino-2-carboxyethyl)thio)-2-((S)-2,2-dimethylcyclopropane-1-carboxamido)hept-2-enoic acid;mk-791;Cilastain;CILASTATIN;Cilistatin Acid;Cilastatinic acid;CILASTATIN (MK0791);Cilastatin USP/EP/BP

CBNumber:: CB2781013

Molecular Formula:: C16H26N2O5S

Molecular Weight:: 358.45

MOL File:: 82009-34-5.mol

Modify Date:: 2024/4/1 18:08:31

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Cilastatin Properties

Melting point	156-158°C
Boiling point	655.5±55.0 °C(Predicted)
Density	1.275±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
pka	2.09±0.10(Predicted)
form	Solid
color	White to Light Brown
CAS DataBase Reference	82009-34-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H312-H332-H302

Precautionary statements

P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501

NFPA 704

	0
3		0

Cilastatin Chemical Properties,Uses,Production

Description

Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase. It inhibits human renal dipeptidase (K_i = 0.7 μM), porcine dipeptidase (IC₅₀ = 0.11 μM), and bacterial metallo-β-lactamase CphA from A. hydrophila (IC₅₀ = 178 μM). Cilastatin (200 μg/ml) protects primary porcine renal proximal tubular epithelial cells from nephrotoxicity and apoptosis induced by vancomycin . In a mouse model of systemic infection, cilastatin in combination with imipenem protects mice from S. aureus, E. coli, and P. aeruginosa infection. Cilastatin was designed to inhibit renal metabolism of imipenem and prolong its half-life. Formulations containing cilastatin in combination with imipenem have been used to treat susceptible bacterial infections.

Chemical Properties

White to Light-Yellow Crystalline Powder

Uses

Cilastatin is used for treating diseases caused by polyresistant Gram-negative microorganisms and serious complex infections, including infection of S. aureus. Because of its strong activity against anaerobic bacteria, cilastatin is effective in monotherapy of intraabdominal infections. It is used for infectious diseases of the lower respiratory tract, urinary tract, gynecological infections, bacterial septicemia, and infections of the bones, skin, and so on.

Cilastatin Preparation Products And Raw materials

Raw materials

N,N'-DIOCTADECYLOXACARBOCYANINE P-TOLUENESULFONATE, 99 Amine compound 1,5-Dibromopentane Ethyl heptanoate p-Toluenesulfonic acid

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester Potassium hydroxide Ethyl diethoxyacetate (S)-(+)-2,2-Dimethylcyclopropanecarboxamide ACETYL FLUORIDE

Succinimide 1,3-Dithiane-2-carboxylic acid Tosyl chloride L-Cystine 1,3-Dimercaptopropane

Cyclopropanecarboxylic acid 2,2-Dimethylcyclopropylcyanide POTASSIUM CYANIDE Quinine Activ Ester

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Preparation Products

Cilastatin Suppliers

Global( 241)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
J S LABS	+91-7330612784 +91-7330612784	Tamil Nadu, India	160	58	Inquiry
Hetero Drugs Limited	+91-4023704923 +91-4023704923	Telangana, India	296	58	Inquiry
Nectar Lifesciences Ltd	+91-9357244445 +91-9357244445	Punjab, India	29	58	Inquiry
Unimark Remedies Ltd	+91-2267304120 +91-2267304120	Maharashtra, India	48	58	Inquiry
Sai Teja Drugs and Intermediates Pvt Ltd	+91-9963142345 +91-9963142345	Telangana, India	38	58	Inquiry
UNIMARK REMEDIES LTD	+91-022-67304000	New Delhi, India	37	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry

Supplier	Advantage
J S LABS	58
Hetero Drugs Limited	58
Nectar Lifesciences Ltd	58
Unimark Remedies Ltd	58
Sai Teja Drugs and Intermediates Pvt Ltd	58
UNIMARK REMEDIES LTD	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
SynZeal Research Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58

Cilastatin Spectrum

Cilastatin(82009-34-5)¹HNMR

82009-34-5(Cilastatin)Related Search:

Glycine Dimethyl sulfoxide CHLOROPHOSPHONAZO III Poly(dimethylsiloxane) Betahistine

Betaine N,N-Dimethylacetamide ALTRENOGEST N,N-Dimethyl-1,4-phenylenediamine Lithium diisopropylamide

N,N-Dimethylformamide Dimethyl sulfone Dimethicone ULINASTATIN Cilastatin Sodium Impurity E(EP)

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate 1-Bromo-5-chloropentane Ethyl 7-chloro-2-oxoheptanoate

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Cilistatin Acid (z)-7-[(2s)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-[[(1s)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid (r-(r*,s*-(z)))-)carbonyl)amino) mk-791 CILASTATIN Cilastain (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid [R-[R^<*>^，S^<*>^(Z)]]-7-[(2-Amino-2-carboxyethyl)thio]-2-[[(2，2-dimethylcyclopropyl)carbonyl]amino]-2-heptenoic acid (Z)-7-[[(R)-2-Amino-2-carboxyethyl]thio]-2-[[[(S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid CILASTATIN (MK0791) 2-Heptenoic acid, 7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-, (2Z)- Cilastatin USP/EP/BP CilastatinQ: What is Cilastatin Q: What is the CAS Number of Cilastatin Q: What is the storage condition of Cilastatin Q: What are the applications of Cilastatin Cilastatin acid Cilastatin AMMoniuM Salt (Z)-7-(((R)-2-Amino-2-carboxyethyl)thio)-2-((S)-2,2-dimethylcyclopropane-1-carboxamido)hept-2-enoic acid 5-(4-hydroxyphenyl)isoxazole-8-carboxylicacid Cilastatinic acid 82009-34-5 C16H26N2O5S Inhibitors Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals