ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate

CAS No.: 769195-26-8

Chemical Name:: Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate

Synonyms: RETAG-003;Sitagliptin-10;Sitagliptin Impurity 55;Sitagliptin EP Impurity 17;3-oxo-4-(2,4,5-trifluorophenyl;Methyl 3-oxo-4-(2,4,5-trifluorophenyl);Methyl 2,4,5-trifluoro-b-oxo-benzenebutanoate;Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate;Benzenebutanoicacid,2,4,5-trifluoro-b-oxo-,Methylester;2,4,5-Trifluoro-β-oxo-benzenebutanoic Acid Methyl Ester

CBNumber:: CB01010402

Molecular Formula:: C11H9F3O3

Molecular Weight:: 246.19

MOL File:: 769195-26-8.mol

MSDS File:: SDS

Modify Date:: 2024/3/22 17:12:53

Request For Quotation

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Properties

Melting point	40-41 °C
Boiling point	273.3±35.0 °C(Predicted)
Density	1.330±0.06 g/cm3(Predicted)
refractive index	1.469
Flash point	115.5±20.8 °C
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	9.95±0.46(Predicted)
color	Pale Yellow to Light Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301+H311-H315-H319
Precautionary statements	P501-P270-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P405
HS Code	2918300090

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Chemical Properties,Uses,Production

Chemical Properties

Off-white solid

Uses

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate is a useful synthetic intermediate in the synthesis of Sitagliptin (S491000); a trizolopyrazine dipeptidyl peptidase (DPP) IV inhibitor for the treatment of type II diabetes.

Preparation

The preparation of methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate is as follows:Stage 1: (2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole In acetonitrile for 3.5h;Stage 2: monomethyl monopotassium malonate With triethylamine; magnesium chloride In acetonitrile at 50℃; for 8h;Stage 3: In acetonitrile at 30℃; for 26h.

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Preparation Products And Raw materials

Raw materials

Benzeneacetyl chloride, 2,4,5-trifluoro- Potassium 3-methoxy-3-oxopropanoate 2,4,5-Trifluorophenylacetic acid Benzenebutanoic acid, 2,4,5-trifluoro-β-hydroxy-, methyl ester 5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione

Methyl bromoacetate Methanol

chevron_left

1of2

chevron_right

Preparation Products

(Z)-Methyl 3-aMino-4-(2,4,5-trifluorophenyl)but-2-enoate Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)-

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Suppliers

Global( 155)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
SynThink RESEARCH CHEMICALS	+91-8177860948 +91-8177860948	Mumbai, India	494	58	Inquiry
Delta Finochem Pvt Ltd	+919923159574	Maharashtra, India	67	58	Inquiry
Actis Generics Pvt Ltd	+91-9949094333 +91-9866922779	AndhraPradesh, India	44	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Xinxiang Hongqi District Houyuan Trading Co.,Ltd	+86-0373-3695376 +86-13937349994	China	300	58	Inquiry
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	China	20308	58	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	China	16209	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21669	55	Inquiry

Supplier	Advantage
SynThink RESEARCH CHEMICALS	58
Delta Finochem Pvt Ltd	58
Actis Generics Pvt Ltd	58
A.J Chemicals	58
SynZeal Research Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Xinxiang Hongqi District Houyuan Trading Co.,Ltd	58
Henan Fengda Chemical Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55

769195-26-8(Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate)Related Search:

Succinylcholine Chloride Acarbose Ethambutol Paroxetine Sitagliptin N-Phoshate IMpurity

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one Sitagliptin phosphate Sitagliptin Impurity 31 Sitagliptin impurity H HCl Sitagliptin Impurity 34

(S)-Sitagliptin Phosphate Sitagliptin Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)- (R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate 2,4,5-TRIFLUOROBENZYL CHLORIDE

2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate

chevron_left

1of4

chevron_right

3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER 2,4,5-TRIFLUORO-BETA-OXO-BENZENEBUTANOIC ACID METHYL ESTER Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate 4-(2,4,5 )triflorophenyl 3-oxobutanoic acid, Methy ester 3-oxo-4-(2,4,5-trifluorophenyl Benzenebutanoicacid,2,4,5-trifluoro-b-oxo-,Methylester Methyl 2,4,5-trifluoro-b-oxo-benzenebutanoate Methyl 3-oxo-4-(2,4,5-trifluorophenyl) RETAG-003 Sitagliptin Impurity 55 4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester Sitagliptin-10 3-oxo-4-(2,4,5-trifluorophenyl)butanoic acid methyl ester Benzenebutanoic acid, 2,4,5-trifluoro-β-oxo-, methyl ester Sitagliptin EP Impurity 17 2,4,5-Trifluoro-β-oxo-benzenebutanoic Acid Methyl Ester ethyl (S)-3-acetamido-4-(2,4,5-trifluorophenyl)butanoate 769195-26-8