Acarbose

Acarbose Properties

Melting point	165-170°C
alpha	D18 +165° (c = 0.4 in water)
Boiling point	675.05°C (rough estimate)
Density	1.4278 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	2-8°C
solubility	Very soluble in water, soluble in methanol, practically insoluble in methylene chloride.
form	Solid
pka	12.39±0.20(Predicted)
color	White to Off-White
Water Solubility	Soluble in water.
Merck	14,18
Stability	Hygroscopic
InChIKey	XUFXOAAUWZOOIT-JMPDRRIHSA-N
LogP	-7.935 (est)
CAS DataBase Reference	56180-94-0

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Safety Statements

24/25

WGK Germany

1

RTECS

LZ7153000

HS Code

29400090

Toxicity

LD50 orl-rat: 24 g/kg NIIRDN -,2,1995

NFPA 704

	0
2		0

Acarbose price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	PHR1253	Acarbose Pharmaceutical Secondary Standard; Certified Reference Material	56180-94-0	500MG	₹11593.58	2022-06-14	Buy
Sigma-Aldrich(India)	A8980	Acarbose ≥95%	56180-94-0	1G	₹27657.88	2022-06-14	Buy
TCI Chemicals (India)	A2485	Acarbose	56180-94-0	1G	₹6800	2022-05-26	Buy
TCI Chemicals (India)	A2485	Acarbose	56180-94-0	5G	₹19100	2022-05-26	Buy
SRL	65457	Acarbose extrapure, 95%	56180-94-0	1Gms	₹6400	2022-05-26	Buy

Product number	Packaging	Price	Buy
PHR1253	500MG	₹11593.58	Buy
A8980	1G	₹27657.88	Buy
A2485	1G	₹6800	Buy
A2485	5G	₹19100	Buy
65457	1Gms	₹6400	Buy

Acarbose Chemical Properties,Uses,Production

Description

Acarbose, a complex oligosaccharide isolated from Actinoplanes, is reportedly useful as an adjuvant therapy in diabetes. By inhibiting alpha-glucosidase, acarbose delays carbohydrate metabolism in the gastrointestinal tract and modulates changes in food induced blood sugar levels.

Chemical Properties

Off-White Solid

Uses

Acarbose is pseudo-oligosaccharide with a terminal C7-cyclitol patented in 1975 by Bayer. Acarbose is a component of the amylostatin complex produced by a species of Actinoplanes and Streptomyces. Acarbose acts as a potent inhibitor of alpha-glucosidases and saccharases. Since 1990, acarbose has been used therapeutically for the treatment of type 2 diabetes.

Definition

ChEBI: A tetrasaccharide derivative consisting of a dideoxy-4-{[4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl C7 cyclitol moiety [called valienol (or valienamine)] linked via nitrogen to isomaltotriose.

World Health Organization (WHO)

Acarbose, ana-glucosidase inhibitor, is used as an adjunctive therapy in the control of postprandial hyperglycaemia in non-insulin-dependent diabetes mellitus. Use of two or more hypoglycaemic drugs is not recommended.

General Description

Acarbose is a naturally occurring oligosaccharide,which is obtained from the microorganism Actinoplanes utahensis. It is a white to off-white powder that is soluble in water and has a pKa of 5.1. As one mightexpect, its affinity for α-glucosidase is based on it being apolysaccharide that the enzyme attempts to hydrolyze. Thisallows acarbose to act as a competitive inhibitor, which inturn reduces the intestinal absorption of starch, dextrin, anddissacharides.
It is sold as 25-, 50-, and 100-mg tablets (Precose,generics) dosed with the first bite of each meal, up to t.i.d. Acarbose potently inhibits the glucoamylase activity of MGAM α-glucosidases and the sucrase activity of α-glucosidases, where as isomaltase activity is at most moderately inhibited at concentrations in the range of those in theintestinal lumen upon oral dosing, and trehalase and lactaseare not significantly inhibited. Some inhibition of pancreaticα-amylases may also contribute to the clinical effects.
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Clinical Use

Based on the structure of acarbose, it should come as nosurprise that little intact acarbose reaches the systemic circulation;instead, acarbose is extensively biotransformed by the actionof microbes and digestive enzymes in the gut. Only about35% of the radioactivity in a dose of ¹⁴C-labeled acarbose administeredorally to men was excreted in the urine, appearingas several metabolites, some of which are phase II conversionproducts of 4-methylpyrogallol (O-methyl, O-sulfate, orO-glucuronide conjugates); the methylpyrogallol fragmentarises from the terminal valienamine pseudosugar. That thesebiotransformation products are mostly formed in the gut isshown by the fact that nearly 90% of an intravenously administereddose of acarbose is excreted intact in urine.

Safety Profile

Low toxicity by ingestion,subcutaneous, and intravenous routes. Human systemiceffects: liver function impaired. When heated todecomposition it emits toxic vapors of NOx.

Acarbose Preparation Products And Raw materials

Raw materials

Preparation Products

Acarbose Suppliers

Global( 636)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
ANWITA APIS	+919000311012	Hyderabad, India	198	58	Inquiry
Vijaya Pharma And Life Science	+91-8939866271 +91-8939866271	Tamil Nadu, India	320	58	Inquiry
OCEAN TRADING CORPORATION	+91(22) 24921669	New Delhi, India	6211	58	Inquiry
VIVAN Life Sciences Pvt. Limited.	+91(22) 2544 4584 / 2544 4585	New Delhi, India	138	50	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Otto Chemie Pvt. Ltd.	+91 9820041841	Mumbai, India	5873	58	Inquiry
Alfa Aesar	1 800 209 7001	Maharashtra, India	6913	58	Inquiry
Sisco Research Laboratories Pvt. Ltd.	+91-22-4268 5800	Mumbai, India	4317	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Triveni chemicals	08048762458	New Delhi, India	6093	58	Inquiry

Supplier	Advantage
ANWITA APIS	58
Vijaya Pharma And Life Science	58
OCEAN TRADING CORPORATION	58
VIVAN Life Sciences Pvt. Limited.	50
TCI Chemicals (India) Pvt. Ltd.	58
Otto Chemie Pvt. Ltd.	58
Alfa Aesar	58
Sisco Research Laboratories Pvt. Ltd.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Triveni chemicals	58

Acarbose Spectrum

Acarbose(56180-94-0)MS

56180-94-0(Acarbose)Related Search:

EC 2.6.1.2 Sulfamic acid Acetaminophen Glucosamine Aminopyrine

Cyclohexene 2-Cyclohexen-1-one Valienamine MALTOTRIOSE Acarbose Impurity H

Acarbose Impurity C Acarbose Impurity F Acarbose Impurity A Acarbose Impurity B Acarbose Impurity E

Acarbose Impurity D ACARBOSE FOR IDENTIFICATION Acarbose-D4

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4)-O-a-D-glucopyranosyl-(1® D-Glucose,O-4,6-dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxyMethyl)-2-cyclohexen-1-yl]aMino]-a-D-glucopyranosyl-(1® Acarbose (Acarbosum) (2R,3R,4R,5S,6R)-5-((2R,3R,4R,5S,6R)-5- O-4,6-Dideoxy-4-[[[1S-(1α,4α,5β,6α)]-4,5,6-trihydroxy-3-(hydroxyMethyl)-2-cyclohexen-1-yl]aMino]-α-D-glucopyranosyl-(1-4)-O-α-D-glucopyranosyl-(1-4)-D-glucose Acarbose API O-4,6-DIDEOXY-4-[[[1S-(1A,4A,5BETA,6A)]-4,5,6-TRIHYDROXY-3-(HYDROXYMETHYL)-2-CYCLOHEXEN-1-YL]AMINO]-ALPHA-D-GLUCOPYRANOSYL-(1-4)-O-ALPHA-D-GLUCOPYRANOSYL-(1-4)-D-GLUCOSE 5-[5-[3,4-DIHYDROXY-6-METHYL-5-[[4,5,6-TRIHYDROXY-3-(HYDROXYMETHYL)-1-CYCLOHEX-2-ENYL]AMINO]OXAN-2-YL]OXY-3,4-DIHYDROXY-6-(HYDROXYMETHYL)OXAN-2-YL]OXY-6-(HYDROXYMETHYL)OXANE-2,3,4-TRIOL -alpha-d-glucopyranosyl-(1-4)- bay-g5421 d-glucose,o-4,6-dideoxy-4-(((1s-(1-alpha,4-alpha,5-beta,6-alpha))-4,5,6-trihyd roxy-3-(hydroxymethyl)-2-cyclohexen-1-yl)amino)-alpha-d-glucopyranosyl-(1-4)-o ACARBOSE O-4,6-Dideoxy-4-[[[1S-(1a,4a,5b,6a)]-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-a-D-glucopyranosyl-(1-4)-O-a-D-glucopyranosyl-(1-4)-D-gluco-se Prandase Precos Acarbose fom Actinoplanes sp. ca. 100 FIP-AIU/mg Ascarbose D-Glucose, O-4,6-dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)- D-Glucose, O-4,6-dideoxy-4-[[4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)-, [1S-(1α,4α,5β,6α)]- O-4,6-DIDEOXY-4-[[[1S-(1A,4A,5BETA,6A)]-4,5,6-TRIHYDROXY-3-(HYDROXYMETHY O-4,6-Dideoxy-4-[[[1S-(1a,4a,5,6a)]-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-a-D-glucopyranosyl-(1-4)-O-a-D-glucopyranosyl-(1-4)-D-glucose Bay g 5421：Glucobay O-4，6-Dideoxy-4-[[[1S(1α，4α，5β，6α-)-4，5，6-trihydrDxy-3-(hydroxymethyl)-2-cyclohexen-1-y1]amino]- α-D-glucopyranosyl-(1→4)-O-α-D-ducopyranosyl-(1→4)-D-glucose 4-O-[4-O-[4-[[(1S,4R,5S,6S)-4,5,6-Trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-4,6-dideoxy-α-D-glucopyranosyl]-α-D-glucopyranosyl]-D-glucopyranose O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1-4)-O-α-D-glucopyranosyl-(1-4)-D-Glucose Acarbose ,98% 4",6"-Dideoxy-4"-([1S]-[1,4,6/5]-4,5,6-trihydroxy-3-hydroxymethyl-2-yclohexenylamino)-maltotriose 4-[[5-[[3,4-dihydroxy-6-methyl-5-[[2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-2,3,5,6-tetrahydroxyhexanal Acarbose Ep5 Acarbose for peak identification CRS Acarbose for identification CRS Acarbose CRS Acarbose Hydrate> Acarbose (Acarbosum) (Mixture ofDiastereomers) (3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S, 5S,6R)-3,4-dihydroxy-6-methyl-5-{[(1S,4R,5S,6S)-4 ,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1- yl]amino}oxan-2-yl]oxy}-3,4-dihydroxy-6-(hydroxy methyl)oxan-2-yl]oxy}-6-(hydroxymethyl)oxane-2, 3 4-triol (3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S, 5S,6R)-3,4-dihydroxy-6-methyl-5-{[(1S,4R,5S,6S)-4 ,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1- yl]amino}oxan-2-yl]oxy}-3,4-dihydroxy-6-(hydroxy methyl)oxan-2-yl]oxy}-6-(hydroxymethyl)oxane-2, 3 4-trio (2R,3R,4R,5R)-4-(((2R,3R,4R,5S,6R)-5-(((2R,3R,4S,5S,6R)-3,4-Dihydroxy-6-methyl-5-(((1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl)amino)tetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,3,5,6-tetrahydroxyhexanal Acarbose USP/EP/BP Acarboser Acarbose (1.0mg/ml in DMSO) (2R,3R,4R,5R)-4-(((2R,3R,4R,5S,6R)-5-(((2R,3R,4S,5S,6R)-3,4-Dihydroxy-6-methyl-5-(((1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl)amino)tetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,3,5,6- AcarboseQ: What is Acarbose Q: What is the CAS Number of Acarbose Q: What are the applications of Acarbose Acarbose, ≥95% Acarbose 56180-94-0 Acarbose extrapure, 95% (3S,5S)-5-[(2R,3S,5S)-5-[(2R,3S,5S)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,4-triol Acarbose (COLD SHIPMENT REQUIRED) (1000521) AMylostatin J, Bay g 5421, alpha-GHI Precose Acarbose Hydrate Glucobay Acarbos Acarbose Tablets A.?3-aminopropane-1-sulfonicacid(homotaurine). ACARBOSE 20% DC GRANULES 56180-94-0 637-07-8