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2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide

2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide Structure
CAS No.
316130-82-2
Chemical Name:
2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide
Synonyms
RSVA314;AMPK Activator VI, RSVA314;AMPK Activator VI, RSVA314 - CAS 316130-82-2 - Calbiochem;2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide;Benzoic acid, 2-hydroxy-, 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide
CBNumber:
CB52750689
Molecular Formula:
C18H21N3O3
Molecular Weight:
327.38
MOL File:
316130-82-2.mol
MSDS File:
SDS
Modify Date:
2023/5/4 8:29:06
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2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide Properties

Density 1.18±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble15mg/mL, clear
pka 8.28±0.40(Predicted)
form Yellow solid
color light orange

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H315-H319-H335-H400
Precautionary statements  P261-P273-P305+P351+P338
Hazard Codes  Xi,N
Risk Statements  36/37/38-50
Safety Statements  26-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3

2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 171272 AMPK Activator VI, RSVA314 - CAS 316130-82-2 - Calbiochem The AMPK Activator VI, RSVA314 modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Biochemicals application 316130-82-2 10MG ₹10550.01 2022-06-14 Buy
Product number Packaging Price Buy
171272 10MG ₹10550.01 Buy

2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide Chemical Properties,Uses,Production

General Description

A cell permeable hydrozide that activates AMPK indirectly via a CaMKKβ-dependent pathway similar to resveratrol (Cat. No. 554325), which results in the phosphorylation of Thr-172 on the AMPKα2 subunit. This activator promotes lysosomal amyloid-β degradation in 3 cell lines nearly 40 times more potently than resveratrol with an IC50 of 1-2 μM. Treatment with RSVA314 at 1-3 μM results in a dose-dependent inhibition of the phosphorylation of 3 proteins downstream from mTOR activation including p70S6K, eukaryotic elongation factor 2 kinase (eEF2K), and S6 ribosomal protein, and promotes a robust increase in the phosphorylation of the protein raptor at Ser-792 in western blots. At the same concentrations, it elicits a strong, dose-dependent conversion of the light chain 3 (LC3) protein, a marker involved with autophagy induction, from LC3-I and LC3-II, also in western blots.

Biochem/physiol Actions

RSVA314 is a resveratrol analog that is a potent indirect activator of AMPK (AMP-activated protein kinase). RSVA314 is a potent inhibitor of adipogenesis in vitro in cultured cells and in vivo in mice. Apparently RSVA314 activates AMPK via a mechanism implicating CaMKKβ and LKB1. Also RSVA314 increases intracellular clearance of the amyloidogenic peptide Aβ, the core component of the amyloid plaques.

2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide Preparation Products And Raw materials

Raw materials

Salicylhydrazide Methyl salicylate 4-(Diethylamino)salicylaldehyde

Preparation Products

2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide Suppliers

Global( 11)Suppliers
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Matrix Scientific 803 788-9494 All other calls United States 6655 80 Inquiry
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Beijing Taize Ruida Technology Co., Ltd. 400-800-8151 13651185998 CHINA 6536 58 Inquiry
Beijing Xiangsheng Xingye Technology Co., Ltd. 0136-81184382 13681184382 CHINA 5130 58 Inquiry
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Beijing Fubo Biotechnology Co., Ltd. 010-57263844 13260236521 CHINA 6039 58 Inquiry
Guangzhou Weijia Technology Co., Ltd. 020-84224925 18300190102 CHINA 6748 58 Inquiry
Shanghai Haoran Biotechnology Co., Ltd. 021-54046791 CHINA 6968 58 Inquiry
Dongguan Biaobiao Experimental Equipment Technology Co., Ltd. 0769-89974612 CHINA 6673 58 Inquiry
Supplier Advantage
Matrix Scientific 80
Aronis 60
Riedel-de Haen AG 87
Beijing Taize Ruida Technology Co., Ltd. 58
Beijing Xiangsheng Xingye Technology Co., Ltd. 58
Beijing Shengke Boyuan Biotechnology Co., Ltd. 58
Beijing Fubo Biotechnology Co., Ltd. 58
Guangzhou Weijia Technology Co., Ltd. 58
Shanghai Haoran Biotechnology Co., Ltd. 58
Dongguan Biaobiao Experimental Equipment Technology Co., Ltd. 58
2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide RSVA314 AMPK Activator VI, RSVA314 AMPK Activator VI, RSVA314 - CAS 316130-82-2 - Calbiochem Benzoic acid, 2-hydroxy-, 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide 316130-82-2