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Benzenebutanamine, α-(3,4-dimethoxyphenyl)-N,N-dimethyl-, hydrochloride (1:1)

Benzenebutanamine, α-(3,4-dimethoxyphenyl)-N,N-dimethyl-, hydrochloride (1:1) Structure
CAS No.
5974-09-4
Chemical Name:
Benzenebutanamine, α-(3,4-dimethoxyphenyl)-N,N-dimethyl-, hydrochloride (1:1)
Synonyms
CBNumber:
CB53357324
Molecular Formula:
C20H27NO2.ClH
Molecular Weight:
349.9
MOL File:
5974-09-4.mol
Modify Date:
2023/5/9 9:30:44
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Benzenebutanamine, α-(3,4-dimethoxyphenyl)-N,N-dimethyl-, hydrochloride (1:1) Properties

Melting point 146-148°

Benzenebutanamine, α-(3,4-dimethoxyphenyl)-N,N-dimethyl-, hydrochloride (1:1) Chemical Properties,Uses,Production

Originator

Monzal ,Boenhringer Ingelheim

Manufacturing Process

1.5 mole magnesium and 1 mole 3-phenylpropyl bromide were used for preparing of ester solution of Grignar reagent. 1 mole (3,4- dimethoxyphenyl)dimethylaminoacetonitrile in absolute ester was added to above reagent dropwise. Then the mixture was heated for 3 hours to reflux. On cooling it was poured into ice with 12% hydrochloric acid. The ester layer was separated. The water layer was alkalized with concentrate ammonia and ammonium chloride. The precipitated oil was dissolved in ester, dried over sodium sulfate and distilled in vacuum after removing of ester to give α-(3,4- dimethoxyphenyl)-N,N-dimethylbenzenebutanamine (vertabutine); BP: 166°- 168°C/0.1 mm Hg. Yield 85%. The free base may be turn into colorless hydrochloride by adding of equivalent of hydrochloric acid in ester; MP: 146°- 148°C.

Therapeutic Function

Uterine relaxant

Benzenebutanamine, α-(3,4-dimethoxyphenyl)-N,N-dimethyl-, hydrochloride (1:1) Preparation Products And Raw materials

Raw materials

Magnesium 1-Bromo-3-phenylpropane

Preparation Products

Benzenebutanamine, α-(3,4-dimethoxyphenyl)-N,N-dimethyl-, hydrochloride (1:1) Suppliers

Global( 2)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd. 15800340161 CHINA 6846 58 Inquiry
Supplier Advantage
AFINE CHEMICALS LIMITED 58
Shanghai Hao Zhun Biological Technology Co., Ltd. 58

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5974-09-4