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GS9620

GS9620 Structure
CAS No.
1228585-88-3
Chemical Name:
GS9620
Synonyms
Gs-20;GS9620;CS-925;GS 9620;GS-9620;Vesatolimod;GS9620, >=98%;GS 9620; GS9620;GS-9620(Vesatolimod);Vesatolimod GS-9620
CBNumber:
CB92666623
Molecular Formula:
C22H30N6O2
Molecular Weight:
410.51
MOL File:
1228585-88-3.mol
MSDS File:
SDS
Modify Date:
2023/9/7 16:59:03
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GS9620 Properties

Density 1.247±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (10 mg/ml)
pka 10.34±0.20(Predicted)
form solid
color Off-white
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

GS9620 Chemical Properties,Uses,Production

Description

GS-9620 is a potent and selective oral Toll-like receptor 7 (TLR7) agonist that directly activates plasmacytoid dendritic cells (pDCs). GS-9620 suppressed hepatitis B virus (HBV) in animal models of chronic infection and transiently activated HIV expressionex vivoin latently-infected peripheral blood mononuclear cells (PBMCs) from virally suppressed patients. Currently, GS-9620 is under clinical evaluation for treating chronic HBV infection and for reducing latent reservoirs in virally-suppressed HIV-infected patients.

References

Lopatin, U, et al. "Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist." Antiviral Therapy18.3(2013):409-18.
Gane, E. J., et al. "The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection." Journal of Hepatology63.2(2015):320.
Lanford, Robert E., et al. "GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees." Gastroenterology 144.7(2013):1508.

GS9620 Preparation Products And Raw materials

Raw materials

Preparation Products

GS9620 Suppliers

Global( 121)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29900 58 Inquiry
Zhejiang ZETian Fine Chemicals Co. LTD +8618957127338 China 2141 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
changzhou huayang technology co., ltd +8615250961469 China 9821 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. 0551-65418684 +8618949823763 China 25363 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Zhejiang ZETian Fine Chemicals Co. LTD 58
Chongqing Chemdad Co., Ltd 58
AFINE CHEMICALS LIMITED 58
Zhejiang J&C Biological Technology Co.,Limited 58
changzhou huayang technology co., ltd 58
InvivoChem 58
Hefei TNJ Chemical Industry Co.,Ltd. 58

GS9620 Spectrum

GS9620(1228585-88-3)1HNMR

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GS9620, >=98% 4-amino-2-butoxy-8-[[3-(pyrrolidin-1-ylmethyl)phenyl]methyl]-5,7-dihydropteridin-6-one 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one 4-Amino-2-butoxy-8-[3-(1-pyrrolidinylmethyl)benzyl]-7,8-dihydro-6(5H)-pteridinone GS 9620 GS9620 GS-9620 4-Amino-2-butoxy-7,8-dihydro-8-[[3-(1-pyrrolidinylmethyl)phenyl]methyl]-6(5H)-pteridinone 8-(3-(pyrrolidin-1-ylMethyl)benzyl)-4-aMino-2-butoxy-7,8-dihydropteridin-6(5H)-one MFCD25372045 (GS-9620) 4-Amino-2-butoxy-7,8-dihydro-8-[[3-(1-pyrrolidinylmethyl)phenyl]methyl]-6(5H)-pteridinone GS 9620 Vesatolimod GS-9620 6(5H)-Pteridinone, 4-amino-2-butoxy-7,8-dihydro-8-[[3-(1-pyrrolidinylmethyl)phenyl]methyl]- Gs-20 GS-9620(Vesatolimod) 4-amino-2-butoxy-8-Chemicalbook(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one CS-925 GS 9620; GS9620 Vesatolimod 6(5H)-Pteridinone, 4-amino-2-butoxy-7,8-dihydro-8-[[3-(1-pyrrolidinylmethyl)phenyl]methyl] HCl GS-9620 Vesatolimod GS9620 1228585-88-3 12285885-88-3 API