Chinese english Japanese Germany Korea

GSK-626616

GSK-626616 Structure
CAS No.
1025821-33-3
Chemical Name:
GSK-626616
Synonyms
GSK-626616;(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone;4(5H)-Thiazolone, 2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-, (5Z)-;GSK 626616,DYRK,Inhibitor,Dual specificity tyrosine regulated kinase,GSK-626616,GSK626616,inhibit,Dual specificity tyrosine phosphorylation regulated kinase
CBNumber:
CB63303333
Molecular Formula:
C18H10Cl2N4OS
Molecular Weight:
401.27
MOL File:
1025821-33-3.mol
Modify Date:
2023/6/30 15:45:59
Request For Quotation

GSK-626616 Properties

Melting point 281 - 282oC
Boiling point 574.8±60.0 °C(Predicted)
Density 1.55±0.1 g/cm3(Predicted)
storage temp. Refrigerator, under inert atmosphere
solubility Chloroform (Slightly, Heated), Methanol (Slightly)
pka -0.94±0.20(Predicted)
form Solid
color Pale Yellow to Light Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319-H335-H302-H315
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
NFPA 704
0
2 0

GSK-626616 Chemical Properties,Uses,Production

Uses

GSK-626616 is a potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable.

GSK-626616 Preparation Products And Raw materials

Raw materials

Preparation Products

GSK-626616 Suppliers

Global( 36)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49739 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686 China 2974 58 Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd. 15800340161 CHINA 6846 58 Inquiry
MedChemExpress 021-58955995 United States 6398 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58
InvivoChem 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
LEAPCHEM CO., LTD. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Shanghai Rechem science Co., Ltd. 58
Shanghai Hao Zhun Biological Technology Co., Ltd. 58
MedChemExpress 58

1025821-33-3(GSK-626616)Related Search:

Entospletinib (GS-9973) GS9620 GSK2643943A GS967 GSK J1
GSK-114 3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester Selonsertib Presatovir 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE
chevron_left

1of2

chevron_right
GSK-626616 (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone 4(5H)-Thiazolone, 2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-, (5Z)- GSK 626616,DYRK,Inhibitor,Dual specificity tyrosine regulated kinase,GSK-626616,GSK626616,inhibit,Dual specificity tyrosine phosphorylation regulated kinase 1025821-33-3