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4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE Structure
CAS No.
101574-65-6
Chemical Name:
4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE
Synonyms
CS-1084;4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide;4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide;(E)-4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide;4-hydroxy-N'-(4-isopropylphenyl‐ methylidene)-benzohydrazide;4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE;2-[[4-(1-Methylethyl)phenyl]methylene]hydrazide 4-hydroxybenzoic acid;4-Hydroxybenzoic acid 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide;Benzoic acid, 4-hydroxy-, 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide
CBNumber:
CB02446303
Molecular Formula:
C17H18N2O2
Molecular Weight:
282.34
MOL File:
101574-65-6.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
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4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE Properties

Density 1.12
storage temp. Inert atmosphere,2-8°C
solubility DMSO: >10mg/mL
form powder
pka 8.48±0.15(Predicted)
color white to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H317-H410
Precautionary statements  P261-P272-P273-P280-P302+P352-P333+P313
Hazard Codes  Xi,N
Risk Statements  43-50/53
Safety Statements  36/37-60-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
HazardClass  9

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) G6173 GSK 4716 ≥98% (HPLC) 101574-65-6 10MG ₹10954.9 2022-06-14 Buy
Sigma-Aldrich(India) G6173 GSK 4716 ≥98% (HPLC) 101574-65-6 50MG ₹43126.8 2022-06-14 Buy
Product number Packaging Price Buy
G6173 10MG ₹10954.9 Buy
G6173 50MG ₹43126.8 Buy

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE Chemical Properties,Uses,Production

Description

The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.

Uses

The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.[Cayman Chemical]

Biological Activity

Selective agonist at estrogen-related receptors ERR β and ERR γ . Displays selectivity over ERR α and the classical estrogen receptors.

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE Preparation Products And Raw materials

Raw materials

Preparation Products

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE Suppliers

Global( 75)Suppliers
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CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
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Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
changzhou huayang technology co., ltd 58
Alfa Chemistry 58
InvivoChem 58
Nanjing Doge Biomedical Technology Co., Ltd 58
TargetMol Chemicals Inc. 58

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE Spectrum

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE(101574-65-6)1HNMR

101574-65-6(4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE)Related Search:

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4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE
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(E)-4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide 4-Hydroxybenzoic acid 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE 2-[[4-(1-Methylethyl)phenyl]methylene]hydrazide 4-hydroxybenzoic acid 4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide CS-1084 Benzoic acid, 4-hydroxy-, 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide 4-hydroxy-N'-(4-isopropylphenyl‐ methylidene)-benzohydrazide 4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide 101574-65-6 Selective agonist at estrogen-related receptors ERRβ and ERRγ.