ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Angiogenesis >Syk inhibitors >Entospletinib (GS-9973)

Entospletinib (GS-9973)

CAS No.: 1229208-44-9

Chemical Name:: Entospletinib (GS-9973)

Synonyms: Entospletinib;6-(1H-indazol-6-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine;GS-9973;CS-1602;GS-9973;GS 9973;GS-9973, Entospletinib;Entospletinib (GS-9973);Entospletinib Dimesylate;GS9973; GS 9973; ENTOSPLETINIB;Entospletinib (GS-9973) USP/EP/BP

CBNumber:: CB92703799

Molecular Formula:: C23H21N7O

Molecular Weight:: 411.46

MOL File:: 1229208-44-9.mol

Modify Date:: 2024/7/2 8:55:41

Request For Quotation

Entospletinib (GS-9973) Properties

Density	1.45±0.1 g/cm3(Predicted)
storage temp.	Desiccate at -20°C
solubility	insoluble in EtOH; insoluble in H2O; ≥20.55 mg/mL in DMSO
form	solid
pka	12.54±0.40(Predicted)
color	White to gray

Entospletinib (GS-9973) Chemical Properties,Uses,Production

Description

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. GS-9973 is a potent Syk inhibitor (IC₅₀ = 7.7 nM) that demonstrates 10-35-fold selectivity for Syk over a panel of 359 nonmutant kinases. In conjunction with the PI3Kδ inhibitor CAL-101 , it has been used to reduce chronic lymphocytic leukemia cell survival and to disrupt chemokine signaling at nanomolar concentrations.

Uses

GS 9973 is a selective and orally bioavailable inhibitor of spleen tyrosine kinase (Syk).

Entospletinib (GS-9973) Preparation Products And Raw materials

Raw materials

Preparation Products

Entospletinib (GS-9973) Suppliers

Global( 124)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	24607	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	China	9991	58	Inquiry
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	China	3136	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
career henan chemical co	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Coresyn Pharmatech Co., Ltd.	58
Nantong HI-FUTURE Biology Co., Ltd.	58

Entospletinib (GS-9973) Spectrum

Entospletinib (GS-9973)(1229208-44-9)¹HNMR

1229208-44-9(Entospletinib (GS-9973))Related Search:

Entrectinib GS9620 GSK2643943A GS967 GSK J1

GSK-114 GSK-626616 3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester Selonsertib Presatovir

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE Dasatinib R406 CAL-101 Ibrutinib

PRT062607 (Hydrochloride) Olaparib

chevron_left

1of4

chevron_right

GS-9973 6-(1H-Indazol-6-yl)-N-[4-(4-morpholinyl)phenyl]imidazo[1,2-a]pyrazin-8-amine Entospletinib (GS-9973) Entospletinib Dimesylate GS-9973, Entospletinib GS-9973;GS 9973 CS-1602 GS9973; GS 9973; ENTOSPLETINIB 6-(1H-indazol-6-yl)-N-(4-morpholin-4-ylphenyl)imidazo[1,2-a]pyrazin-8-amine 6-(1H-INDAZOL-6-YL)-N-(4-MORPHOLINOPHENYL)IMIDAZO[1,2-A]PYRAZIN-8-AMINE，GS-9973 Imidazo[1,2-a]pyrazin-8-amine, 6-(1H-indazol-6-yl)-N-[4-(4-morpholinyl)phenyl]- Entospletinib (GS-9973) USP/EP/BP Entospletinib 6-(1H-indazol-6-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine 1229208-44-9 Inhibitors