N′-(4-イソプロピルベンジリデン)-4-ヒドロキシベンズヒドラジド
N′-(4-イソプロピルベンジリデン)-4-ヒドロキシベンズヒドラジド 物理性質
- 比重(密度) :
- 1.12
- 貯蔵温度 :
- Inert atmosphere,2-8°C
- 溶解性:
- DMSO:>10mg/mL
- 外見 :
- 粉
- 酸解離定数(Pka):
- 8.48±0.15(Predicted)
- 色:
- ホワイトからオフホワイト
N′-(4-イソプロピルベンジリデン)-4-ヒドロキシベンズヒドラジド 価格
もっと(7)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC3075 |
GSK 4716 |
101574-65-6 |
50mg |
¥137000 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
G6173 |
≥98% (HPLC)
GSK 4716 ≥98% (HPLC) |
101574-65-6 |
10mg |
¥16700 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
G6173 |
≥98% (HPLC)
GSK 4716 ≥98% (HPLC) |
101574-65-6 |
50mg |
¥62400 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC3075 |
GSK 4716 |
101574-65-6 |
10mg |
¥32000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01FLC386438 |
(E)-4-HYDROXY-N'-(4-ISOPROPYLBENZYLIDENE)BENZOHYDRAZIDE |
101574-65-6 |
5g |
¥1086900 |
2021-03-23 |
購入 |
N′-(4-イソプロピルベンジリデン)-4-ヒドロキシベンズヒドラジド 化学特性,用途語,生産方法
説明
The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC
50 = 2 μM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.
使用
The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.[Cayman Chemical]
生物活性
Selective agonist at estrogen-related receptors ERR β and ERR γ . Displays selectivity over ERR α and the classical estrogen receptors.
N′-(4-イソプロピルベンジリデン)-4-ヒドロキシベンズヒドラジド 上流と下流の製品情報
原材料
準備製品
N′-(4-イソプロピルベンジリデン)-4-ヒドロキシベンズヒドラジド 生産企業
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N′-(4-イソプロピルベンジリデン)-4-ヒドロキシベンズヒドラジド スペクトルデータ(1HNMR)
101574-65-6(N′-(4-イソプロピルベンジリデン)-4-ヒドロキシベンズヒドラジド)キーワード:
- 101574-65-6
- (E)-4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide
- 4-Hydroxybenzoic acid 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide
- 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE
- 2-[[4-(1-Methylethyl)phenyl]methylene]hydrazide 4-hydroxybenzoic acid
- 4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide
- CS-1084
- Benzoic acid, 4-hydroxy-, 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide
- 4-hydroxy-N'-(4-isopropylphenyl‐
methylidene)-benzohydrazide
- 4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide
- N′-(4-イソプロピルベンジリデン)-4-ヒドロキシベンズヒドラジド
- 4-ヒドロキシ-N'-{[4-(プロパン-2-イル)フェニル]メチリデン}ベンゾヒドラジド
- N′-(4-イソプロピルベンジリデン)-4-ヒドロキシ安息香酸ヒドラジド