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Tetrabenazine

CAS No.: 58-46-8

Chemical Name:: Tetrabenazine

Synonyms: Xenazine;Nitoman;Rubigen;Ro 1-9569;TETRABENAZINE;(3R,11bR)-rel-;TBZ,racemic mixture;TetrabezineImpurity5;Tetrabenazine(Xenazine);Butyl benzene that lamictal

CBNumber:: CB5339246

Molecular Formula:: C19H27NO3

Molecular Weight:: 317.42

MOL File:: 58-46-8.mol

MSDS File:: SDS

Modify Date:: 2023/9/15 16:16:51

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Tetrabenazine Properties

Melting point	128-130?C
Boiling point	456.71°C (rough estimate)
Density	1.12
refractive index	1.5180 (estimate)
storage temp.	2-8°C
solubility	DMSO: >10mg/mL
pka	6.46±0.40(Predicted)
form	solid
color	White
Merck	14,9182
BRN	40090
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
InChIKey	MKJIEFSOBYUXJB-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

Hazard Codes

Risk Statements

Safety Statements

24/25

RIDADR

3249

WGK Germany

RTECS

DK2275000

HazardClass

6.1(b)

PackingGroup

III

HS Code

29339900

NFPA 704

	0
1		0

Tetrabenazine price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	T2952	Tetrabenazine ≥98% (HPLC), solid	58-46-8	10MG	₹15252.43	2022-06-14	Buy
Sigma-Aldrich(India)	T2952	Tetrabenazine ≥98% (HPLC), solid	58-46-8	50MG	₹70394.98	2022-06-14	Buy
Sigma-Aldrich(India)	5.09892	Tetrabenazine, TBZ - CAS 58-46-8 - Calbiochem A monoamine-depleting agent that blocks vesicular monoamine transporter 2 activity. Promotes late-stage differentiation of Pdx1 + pancreatic progenito	58-46-8	10MG	₹15290	2022-06-14	Buy
TCI Chemicals (India)	T2839	Tetrabenazine	58-46-8	200MG	₹9400	2022-05-26	Buy
TCI Chemicals (India)	T2839	Tetrabenazine	58-46-8	1G	₹20800	2022-05-26	Buy

Product number	Packaging	Price	Buy
T2952	10MG	₹15252.43	Buy
T2952	50MG	₹70394.98	Buy
5.09892	10MG	₹15290	Buy
T2839	200MG	₹9400	Buy
T2839	1G	₹20800	Buy

Tetrabenazine Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Uses

Tetrabenazine has been used for dopamine uptake assays in mouse brain cells¹. Tetrabenazine has also been used for non-specific binding assays in postnuclear supernatants derived from PC-12 and CV-1 cells².

Definition

ChEBI: A benzoquinolizine that is 1,2,3,4,4a,9,10,10a-octahydrophenanthrene in which the carbon at position 10a is replaced by a nitrogen and which is substituted by an isobutyl group at position 2, an oxo group at position 3, and methoxy groups at positions 6 an 7.

General Description

A cell permeable benzoquinolizine based compound that acts as a monoamine-depleting agent by blocking the activity vesicular monoamine transporter 2. Promotes late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3 (Ngn3)-positive endocrine precursors without increasing their proliferation. Increases the number of insulin expressing cells in a dose dependent manner (EC₅₀ = 220 nM) and this effect is significantly enhanced when cells are simultaneously treated with dibutyryl cAMP. Embryonic stem cells treated with TBZ and/or dibutyryl cAMP and then grafted into kidney capsule of AKITA mice reduce hyperglycemia, improve fasting blood glucose levels, and show an increase in plasma C-peptide levels.

Biological Activity

Potent inhibitor of vesicular monoamine uptake; depletes stores of dopamine, serotonin and noradrenalin. Binds with high affinity (IC 50 = 3.2 nM) to vesicular monoamine transporter (VMAT) in chromaffin granule membranes and displays higher affinity for VMAT2 than VMAT1. Also reported to block dopamine receptors. Causes behavioral depression; inhibits locomotor activity and produces hypothermia upon systemic administration in rats and mice.

Purification Methods

Crystallise it from MeOH. The hydrochloride has m 208-210o, and the oxime has m 158o (from EtOH). [Beilstein 21 III/IV 6488.]

Tetrabenazine Preparation Products And Raw materials

Raw materials

7-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 1,2,3,4-TETRAHYDROISOQUINOLINE (2-Acetyl-4-Methylpentyl)triMethylaMMoniuM Iodide 6,7-Dimethoxy-3,4-dihydroisoquinoline

Preparation Products

Tetrabenazine Suppliers

Global( 249)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Siddhivinayakchemicals	+91-912225190111 +91-9819773074	Mumbai, India	42	58	Inquiry
Vadivarhe Speciality Chemicals Limited	+91-9028832204 +91-9028832204	Maharashtra, India	38	58	Inquiry
Piramal Pharma Solutions	+919892735994	Maharashtra, India	48	58	Inquiry
Apotex Pharmachem India Pvt Ltd	+91-8022891034 +91-8022891000	Karnataka, India	109	58	Inquiry
Sun Pharmaceutical Industries Ltd	+91-2242244224 +91-2243244324	Maharashtra, India	108	58	Inquiry
Mylan Laboratories Ltd	+91-4023550543 +91-4030866666	Telangana, India	150	58	Inquiry
Apicore Pharmaceuticals Pvt Ltd	+91-2662267177 +91-2662267166	Gujarat, India	181	58	Inquiry
Equilife Laboratories Pvt Ltd	+91-8007935656 +91-9822319778	Maharashtra, India	29	58	Inquiry
Synnat Pharma Pvt Ltd	+91-9966980001 +91-9989984964	AndhraPradesh, India	22	58	Inquiry
Enaltec Labs Pvt Ltd	+91-9167119247 +91-9167119247	Maharashtra, India	49	58	Inquiry

Supplier	Advantage
Siddhivinayakchemicals	58
Vadivarhe Speciality Chemicals Limited	58
Piramal Pharma Solutions	58
Apotex Pharmachem India Pvt Ltd	58
Sun Pharmaceutical Industries Ltd	58
Mylan Laboratories Ltd	58
Apicore Pharmaceuticals Pvt Ltd	58
Equilife Laboratories Pvt Ltd	58
Synnat Pharma Pvt Ltd	58
Enaltec Labs Pvt Ltd	58

Tetrabenazine Spectrum

TETRABENAZINE(58-46-8)MS

58-46-8(Tetrabenazine )Related Search:

1-(3-METHOXY-PHENYL)-ETHYLAMINE 1-Phenethyl-4-piperidone 1-Methyl-4-piperidone N-Methylhomoveratrylamine 1-Ethyl-4-piperidone

Salsoline Tetrabenazine 2-Methyl-4-piperidone 1-Propyl-4-piperidone Tetrabenazine metabolite A,Tetrabenazine metabolite B

2H-BENZO[A]QUINOLIZIN-2-ONE, 1,3,4,6,7,11B-HEXAHYDRO-9,10-DIMETHOXY-3-(2-METHYLPROPYL)-, (3S,11BS)- 6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE 1-PHENYL-BUTYLAMINE AKOS BC-3154 1-(4-METHOXY-PHENYL)-PROPYLAMINE

Isoquinoline, 1,2,3,4-tetrahydro-2-methyl- Benzenepentanamine CHEMBRDG-BB 6594188

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1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one Nitoman Ro 1-9569 Rubigen cis-9,10-Dimethoxy-1,3,4,6,7,11b-hexahydro-3-isobutyl-2H-benzo[a]quinolizin-2-one 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydropyrido[2,1-a]isoquinolin-2-one 9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydropyrido[2,1-a]isoquinolin-2-one 3-Isobutyl-9,10-diMethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH) (3R,11bR)-rel- 3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizin-2-one 9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one (3R,11BR)-REL-1,3,4,6,7,11B-HEXAHYDRO-9,10-DIMETHOXY-3-(2-METHYLPROPYL)-2H-BENZO[A]QUINOLIZIN-2-ONE TETRABENAZINE 2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (3R,11bR)-rel- 9,10-Dimethoxy-1,3,4,6,7,11b-hexahydro-3-isobutyl-2H-benzo[a]quinolizin-2-one Tetrabenazine(Xenazine) Tetrabenazine Related Impurity 5 Tetrabenazine, 99%, a VMAT-inhibitor TBZ,racemic mixture TETRABENAZINE ISO 9001：2015 REACH TetrabenazineQ: What is Tetrabenazine Q: What is the CAS Number of Tetrabenazine Q: What is the storage condition of Tetrabenazine Q: What are the applications of Tetrabenazine Xenazine Butyl benzene that lamictal TetrabezineImpurity5 2-amino-1-(7-bromophenyl)ethanol 13C2,2H6]-Tetrabenazine, racemic mixture rel-(3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one trans (2,3)-Dihydro Tetrabenazine-d6 (Isobutyl D6) 58-46-8 164106-49-8 Serotonin receptor APIs Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Other APIs 58-46-8