27-DEOXYACTEIN
- CAS No.
- 264624-38-6
- Chemical Name:
- 27-DEOXYACTEIN
- Synonyms
- Deoxycosimatin;27-DEOXYACTEIN;26-DEOXYACTEIN;DEOXYACTEIN, 27-;23-EPI-26-DEOXYACTEIN;23-EPI-26-Deoxyactein (20 mg);DEOXYACTEIN, 27-(23-EPI-26-DEOXYACTEIN)(P);Inhibitor,26Deoxyactein,26-Deoxyactein,inhibit,26 Deoxyactein;β-D-Xylopyranoside, (3β,12β,16β,23S,24R,25R)-12-(acetyloxy)-16,23:23,26:24,25-triepoxy-9,19-cyclolanostan-3-yl;(3beta,12beta,16beta,23S,24R,25R)-12-(Acetyloxy)-16,23:23,26:24,25-triepoxy-9,19-cyclolanostan-3-yl beta-D-xylopyranoside
- CBNumber:
- CB5365803
- Molecular Formula:
- C37H56O10
- Molecular Weight:
- 660.83
- MOL File:
- 264624-38-6.mol
- Modify Date:
- 2023/5/4 17:34:36
| Melting point | 253～254℃ |
|---|---|
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), Methanol (Very Slightly), Pyridine (Slightly) |
| form | Solid |
| pka | 13.03±0.70(Predicted) |
| color | White to Off-White |
| Stability | Hygroscopic |
27-DEOXYACTEIN Chemical Properties,Uses,Production
Description
23-epi-26-Deoxyactein is a triterpene glycoside and a major constituent of black cohosh (C. racemosa). It reduces intracellular calcium concentrations, collapse of the mitochondrial membrane potential, production of reactive oxygen species (ROS), and cardiolipin peroxidation and inhibits autophagy and apoptosis in osteoblastic MC3T3-E1 cells induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). 23-epi-26-Deoxyactein (0.01-10 μM) reduces production of ROS and IL-1β and cell death induced by methylglyoxal in RIN-m5F β-cells.
Uses
27-Deoxyactein has shown stimulation of osteoblast function and inhibits bone resorbing mediators in the treatment of osteoporosis. It is a derivative of Actein (A191800), a gamma secretase modulators derived from botanicals.
27-DEOXYACTEIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18648 | 58 | Inquiry |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | CHINA | 1824 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3777 | 58 | Inquiry |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | China | 3000 | 58 | Inquiry |
| LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | China | 2972 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Shanghai Zhiyun Biotechnology Co., Ltd | 13119135307 | China | 2768 | 58 | Inquiry |
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