3,6-DIOXA-1,8-OCTANEDITHIOL
- CAS No.
- 14970-87-7
- Chemical Name:
- 3,6-DIOXA-1,8-OCTANEDITHIOL
- Synonyms
- 1,8-DIMERCAPTO-3,6-DIOXAOCTANE;2,2’-(ethylenedioxy)diethanethiol;SH-PEG2-SH;Triglycoldimercaptan;3,6-dioxa-1,8-octandithiol;3,6-dioxy-1,8-octyldithiol;3,6-DIOXA-1,8-OCTANEDITHIO;3,6-DIOXA-1,8-OCTANEDITHIOL;3,6-Dioxa-1,8-OCLanedithiol;Triethyleneglycol dimrcaptan
- CBNumber:
- CB5379455
- Molecular Formula:
- C6H14O2S2
- Molecular Weight:
- 182.3
- MOL File:
- 14970-87-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/17 18:13:28
| Boiling point | 225 °C(lit.) |
|---|---|
| Density | 1.12 g/mL at 25 °C(lit.) |
| vapor pressure | 0.39Pa at 20℃ |
| refractive index |
n |
| Flash point | 132 °C |
| solubility | Slightly soluble in water |
| form | clear liquid |
| pka | 9.34±0.10(Predicted) |
| color | Colorless to Light yellow to Light orange |
| Water Solubility | 11.4g/L at 19.8℃ |
| BRN | 1901671 |
| InChI | InChI=1S/C6H14O2S2/c9-5-3-7-1-2-8-4-6-10/h9-10H,1-6H2 |
| InChIKey | HCZMHWVFVZAHCR-UHFFFAOYSA-N |
| SMILES | C(OCCS)COCCS |
| LogP | 1.6 at 55℃ |
| CAS DataBase Reference | 14970-87-7(CAS DataBase Reference) |
| EPA Substance Registry System | Ethanethiol, 2,2'-[1,2-ethanediylbis(oxy)]bis- (14970-87-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H332-H410 | |||||||||
| Precautionary statements | P261-P264-P270-P273-P301+P310-P304+P340+P312 | |||||||||
| Hazard Codes | T,N,Xn | |||||||||
| Risk Statements | 22-23-36/37/38-51/53-20/22 | |||||||||
| Safety Statements | 26-45-61 | |||||||||
| RIDADR | UN 2810 6.1/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| HS Code | 29309090 | |||||||||
| NFPA 704 |
|
3,6-DIOXA-1,8-OCTANEDITHIOL price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 465178 | 2,2′-(Ethylenedioxy)diethanethiol 95% | 14970-87-7 | 100ML | ₹3215.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 465178 | 2,2′-(Ethylenedioxy)diethanethiol 95% | 14970-87-7 | 500ML | ₹12178.13 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D2649 | 3,6-Dioxa-1,8-octanedithiol min. 97.0 % | 14970-87-7 | 25G | ₹1800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D2649 | 3,6-Dioxa-1,8-octanedithiol min. 97.0 % | 14970-87-7 | 100G | ₹5300 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D2649 | 3,6-Dioxa-1,8-octanedithiol min. 97.0 % | 14970-87-7 | 500G | ₹9400 | 2022-05-26 | Buy |
3,6-DIOXA-1,8-OCTANEDITHIOL Chemical Properties,Uses,Production
Uses
3,6-dioxa-1,8-octanedithiol (DODT) was used for cleaving peptides in the study to develop synthetic peptide serology to treat chronic chagas disease. DODT may be used to develop non-malodorous scavenger in Fmoc-based peptide synthesis.
Definition
3,6-dioxa-1,8-octanedithiol is a dithiol monomer. This compound could be chosen as a model compound for the active sites of thioredoxins to study its reactions with cis-[Pt(NH3)2Cl4] and trans-[PtCl2(CN)4]2– (cisplatin prodrug and a model complex). The pKa values for the dithiol were characterized to be 8.7 ± 0.2 and 9.6 ± 0.2 at 25.0 °C and an ionic strength of 1.0 M. Triethylamine (TEA) and dilute H2O2 could catalyze the new Radical Ring-opening Redox Polymerization (R3P) of 3,6-dioxa-1,8-octanedithiol[1-2].
Synthesis Reference(s)
The Journal of Organic Chemistry, 33, p. 1275, 1968 DOI: 10.1021/jo01267a089
Triglycol dimercaptan
General Description
3,6-dioxa-1,8-octanedithiol is non volatile in nature.
References
[1] DONGYING MA. Formation of peptide disulfide bonds through a trans-dibromido-Pt(IV) complex oxidation reaction: Kinetic and mechanistic analyses[J]. Journal of Molecular Liquids, 2021. DOI:10.1016/j.molliq.2020.115195.
[2] ROSENTHAL-KIMEMILY Q PuskasJudit E. Green polymer chemistry: investigating the mechanism of radical ring-opening redox polymerization (R3P) of 3,6-dioxa-1,8-octanedithiol (DODT).[J]. Molecules, 2015. DOI:10.3390/molecules20046504.
3,6-DIOXA-1,8-OCTANEDITHIOL Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SANTO RIGHELLO PVT ltd | +91 9885571757 | Telangana, India | 41 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| JINING XINHE CHEMICAL CO., LTD | +8615318402391 | China | 807 | 58 | Inquiry |
| Shanghai Gubang New Materail Technology Co. LTD | 21-51317962 +8618721305404 | CHINA | 272 | 58 | Inquiry |
| Zhengzhou Anhuida Chemical Co., Ltd | +8615903659408 | China | 294 | 58 | Inquiry |
| Hebei Longbang Technology Co., LTD | +86-18032476855 +86-18032476855 | China | 942 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | China | 5832 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20296 | 58 | Inquiry |