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SIB 1893

SIB 1893 Structure
CAS No.
6266-99-5
Chemical Name:
SIB 1893
Synonyms
SIB 1893;NSC 36665;(E/Z)-SIB-1893;(E/Z)SIB1893,(E/Z) SIB 1893;(E)-2-METHYL-6-STYRYL-PYRIDINE;2-METHYL-6-(2-PHENYLETHENYL)PYRIDINE;(E)-2-METHYL-6-(2-PHENYLETHYL)-PYRIDINE;Pyridine, 2-methyl-6-(2-phenylethenyl)-;2-Methyl-6-[(E)-2-phenylethenyl]pyridine
CBNumber:
CB5393055
Molecular Formula:
C14H13N
Molecular Weight:
195.26
MOL File:
6266-99-5.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:11
Request For Quotation

SIB 1893 Properties

storage temp. 2-8°C
solubility DMSO: 18 mg/mL
form solid
color White to off-white

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3

SIB 1893 Chemical Properties,Uses,Production

Uses

SIB 1893 is a selective antagonist of mGluR-5. SIB 1893 acts as a positive allosteric modulator of human metabotropic mGlu4 (1). Anticonvulsant (2).

Biological Activity

A highly selective non-competitive antagonist for the metabotropic glutamate mGlu 5 receptor subtype; displays an IC 50 value of 0.3 μ M? at hmGlu 5 , compared with > 100 μ M at hmGlu 1b , hmGlu 2 , hmGlu 6 , hmGlu 7 and hmGlu 8 . Centrally active upon systemic administration in vivo . Positive allosteric modulator at mGlu 4 receptors.

SIB 1893 Preparation Products And Raw materials

Raw materials

Preparation Products

SIB 1893 Suppliers

Global( 41)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
HangZhou YuHao Chemical Technology Co., Ltd. 0571-82693216 China 2031 58 Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826 China 48467 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9274 58 Inquiry
Jinan Jiuli Biotechnology Co. , Ltd. 486064515 China 2574 58 Inquiry
United States Biological 800.520.3011 or 781.639.5092 United States 6256 80 Inquiry
Supplier Advantage
Capot Chemical Co.,Ltd. 60
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Aladdin Scientific 58
HangZhou YuHao Chemical Technology Co., Ltd. 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58
RD International Technology Co., Limited 58
Jinan Jiuli Biotechnology Co. , Ltd. 58
United States Biological 80

6266-99-5(SIB 1893)Related Search:

ETHYLENE stilbazium iodide SIB 1893 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(3-NITROPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 4-(1,3-BENZODIOXOL-5-YL)-2-(4-METHOXYSTYRYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE
4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(3-BROMOPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(2-CHLOROPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 2-[(E)-2-(4-FLUOROPHENYL)ETHENYL]-5-OXO-4-(3,4,5-TRIMETHOXYPHENYL)-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(3-CHLOROPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 4-(1,3-BENZODIOXOL-5-YL)-2-(3,4-DICHLOROSTYRYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE
4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(4-FLUOROPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(4-CHLOROPHENYL)ETHENYL]-5H-INDENO[1,2-B]PYRIDIN-5-ONE 4-(2-FLUOROPHENYL)-2-[(E)-2-(3-METHOXYPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 2-[(E)-2-(3-CHLOROPHENYL)ETHENYL]-4-(4-HEPTYLPHENYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(2-FLUOROPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE
4-(1,3-BENZODIOXOL-5-YL)-2-(4-HYDROXYSTYRYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 4-(1,3-BENZODIOXOL-5-YL)-2-(4-NITROSTYRYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE
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SIB 1893 2-METHYL-6-(2-PHENYLETHENYL)PYRIDINE (E)-2-METHYL-6-(2-PHENYLETHYL)-PYRIDINE (E)-2-METHYL-6-STYRYL-PYRIDINE 2-Methyl-6-[(E)-2-phenylethenyl]pyridine NSC 36665 Pyridine, 2-methyl-6-(2-phenylethenyl)- (E/Z)-SIB-1893 (E/Z)SIB1893,(E/Z) SIB 1893 6266-99-5 Glutamate receptor