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Canagliflozin-10

Canagliflozin-10 Structure
CAS No.
2161394-94-9
Chemical Name:
Canagliflozin-10
Synonyms
Canagliflozin-10;canagliflozin impurities3;canagliflozin impurities613;Canagliflozin Furanose Form (Mixture of Anomers);D-Galactitol, 1,4-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-;(2R,3R,4R,5R)-2-((R)-1,2-dihydroxyethyl)-5-(3-((5-(4- fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl) tetrahydrofuran-3,4-diol;Canagliflozin impurity 9/(2R,3R,4R,5R)-2-((R)-1,2-dihydroxyethyl)-5-(3-((5-(4- fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl) tetrahydrofuran-3,4-diol
CBNumber:
CB54819427
Molecular Formula:
C24H25FO5S
Molecular Weight:
444.52
MOL File:
2161394-94-9.mol
Modify Date:
2023/4/23 13:52:06

Canagliflozin-10 Properties

Melting point >53°C (dec)
Boiling point 673.5±55.0 °C(Predicted)
Density 1.375±0.06 g/cm3(Predicted)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly, Sonicated)
pka 13.56±0.70(Predicted)
form Solid
color White to Off-White
Stability Hygroscopic

Canagliflozin-10 Chemical Properties,Uses,Production

Uses

1-C-[3-[[5-(4-Fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucose is an intermediate used in the synthesis of Canagliflozin (C175190). Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor; Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.

Canagliflozin-10 Preparation Products And Raw materials

Raw materials

Preparation Products

(2R,3R,4R,5R)-2-((R)-1,2-dihydroxyethyl)-5-(3-((5-(4- fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl) tetrahydrofuran-3,4-diol Canagliflozin impurity 9/(2R,3R,4R,5R)-2-((R)-1,2-dihydroxyethyl)-5-(3-((5-(4- fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl) tetrahydrofuran-3,4-diol D-Galactitol, 1,4-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]- Canagliflozin Furanose Form (Mixture of Anomers) canagliflozin impurities613 canagliflozin impurities3 Canagliflozin-10 2161394-94-9