Pioglitazone hydrochloride
![Pioglitazone hydrochloride Structure](CAS/GIF/112529-15-4.gif)
- CAS No.
- 112529-15-4
- Chemical Name:
- Pioglitazone hydrochloride
- Synonyms
- PIOGLITAZONE HCL;ACTOS;Piog;PiogL;AD-4833;U-72107E;U-72107A;itazone HydrochL;$350/50G,99%,IN STOCK;Pioglitazone Hydro...
- CBNumber:
- CB0411844
- Molecular Formula:
- C19H21ClN2O3S
- Molecular Weight:
- 392.9
- MOL File:
- 112529-15-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
Melting point | 193-194°C |
---|---|
RTECS | XJ5813440 |
storage temp. | 2-8°C |
solubility | DMSO: ≥10mg/mL |
form | powder |
color | white to off-white |
Water Solubility | Soluble in water (<1 mg/ml at 25°C), DMF, methanol, ethanol (4 mg/ml at 25°C), and DMSO (79 mg/ml at 25°C). |
Merck | 14,7452 |
BCS Class | 2 |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
InChIKey | GHUUBYQTCDQWRA-UHFFFAOYSA-N |
CAS DataBase Reference | 112529-15-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H319 | |||||||||
Precautionary statements | P264-P280i-P305+P351+P338-P337+P313 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/38-36 | |||||||||
Safety Statements | 22-24/25-26 | |||||||||
WGK Germany | 3 | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29341000 | |||||||||
NFPA 704 |
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Pioglitazone hydrochloride price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | E6910 | Pioglitazone hydrochloride ≥98% (HPLC) | 112529-15-4 | 10MG | ₹8746.6 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | PHR1632 | Pioglitazone hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 112529-15-4 | 500MG | ₹12004.93 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | E6910 | Pioglitazone hydrochloride ≥98% (HPLC) | 112529-15-4 | 50MG | ₹32258.5 | 2022-06-14 | Buy |
TCI Chemicals (India) | P1901 | Pioglitazone Hydrochloride | 112529-15-4 | 5G | ₹14600 | 2022-05-26 | Buy |
TCI Chemicals (India) | P1901 | Pioglitazone Hydrochloride | 112529-15-4 | 25G | ₹20800 | 2022-05-26 | Buy |
Pioglitazone hydrochloride Chemical Properties,Uses,Production
Description
Pioglitazone is a new orally active thiazolidinedione (TZD) launched in the US for the treatment of non-insulin dependent diabetes mellitus (NIDDM). It can be synthesized in 4 steps, the last one transforming an alphabromoester into thiazolidine with thiourea. As with other representatives in this class, it potently activates the nuclear receptor peroxisome proliferator-activated receptor gamma which is believed to be involved in the regulation of insulin resistance and adipogenesis. In several obese and obese diabetic animal models, treatment with Pioglitazone resulted in reductions in plasma glucose and serum lipids. In clinical studies, Pioglitazone at a once daily oral dose of 15-45 mg, as monotherapy or in combination with non-TZDs or insulin, was shown to significantly improve glycemic control in type-2 diabetes and demonstrated a beneficial effect on insulin resistance and other clinically relevant parameters as plasma levels of triglycerides or HDL-cholesterol. Pioglitazone is reported to be safe and well tolerated and is said to have a lower occurrence of hepatic toxicity as well as a low probability for drug interaction.
Chemical Properties
Colourless Prisms
Uses
Pioglitazone hydrochloride is a euglycemic agent,used as an antidiabetic.
General Description
Pioglitazone hydrochloride is an oral antidiabetic agent used in the treatment of type 2 diabetes mellitus (also known as non-insulin-dependent diabetes mellitus (NIDDM) or adult-onset diabetes.
Pioglitazone hydrochloride Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
Vardhaman P Golechha | 9704422000 | Telangana, India | 294 | 58 | Inquiry |
Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
Nivika Chemo Pharma Pvt Ltd | +91-9824176501 +91-9824176501 | Gujarat, India | 15 | 58 | Inquiry |
Vidgas science and technologies Pvt Ltd | +91-9030019844 +91-9030019844 | Telangana, India | 76 | 58 | Inquiry |
USV Pvt Ltd | +91-2267861111 +91-2225564048 | Maharashtra, India | 36 | 58 | Inquiry |
Aurobindo Pharma Limited | +914066725000 | Telangana, India | 112 | 58 | Inquiry |
Apotex Pharmachem India Pvt Ltd | +91-8022891034 +91-8022891000 | Karnataka, India | 109 | 58 | Inquiry |
Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
JPN Pharma Pvt Ltd | +919833233531 | Maharashtra, India | 33 | 58 | Inquiry |
Supplier | Advantage |
---|---|
Jigs Chemical ltd | 58 |
Vardhaman P Golechha | 58 |
Dr. Reddy's Laboratories Ltd | 58 |
Nivika Chemo Pharma Pvt Ltd | 58 |
Vidgas science and technologies Pvt Ltd | 58 |
USV Pvt Ltd | 58 |
Aurobindo Pharma Limited | 58 |
Apotex Pharmachem India Pvt Ltd | 58 |
Cipla Ltd | 58 |
JPN Pharma Pvt Ltd | 58 |
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