ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Metabolism >PPAR activators >WY-14643
WY-14643
- CAS No.
- 50892-23-4
- Chemical Name:
- WY-14643
- Synonyms
- CS-737;WY-14643;Pirinixic;NSC 310038;wyeth14,643;Chloro Acid;pirnixicacid;99.0%(LC&PIRINIXIC ACID;WY-14643/WY14643
- CBNumber:
- CB9345027
- Molecular Formula:
- C14H14ClN3O2S
- Molecular Weight:
- 323.8
- MOL File:
- 50892-23-4.mol
- Modify Date:
- 2024/11/19 15:53:33
| Melting point | 155°C |
|---|---|
| Boiling point | 514.4±50.0 °C(Predicted) |
| Density | 1.2984 (rough estimate) |
| refractive index | 1.5630 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO (up to 40 mg/ml). |
| form | White crystalline solid |
| pka | 2.99±0.10(Predicted) |
| color | Off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H319-H335-H350 | |||||||||
| Precautionary statements | P201-P301+P312+P330-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 45-22-36/37/38 | |||||||||
| Safety Statements | 53-26-36/37/39-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AG2915000 | |||||||||
| HS Code | 2933.59.9500 | |||||||||
| Hazardous Substances Data | 50892-23-4(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
WY-14643 price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C7081 | WY-14643 | 50892-23-4 | 10MG | ₹6137.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C7081 | WY-14643 | 50892-23-4 | 50MG | ₹18640.65 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C1323 | [4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid | 50892-23-4 | 1G | ₹7400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C1323 | [4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid | 50892-23-4 | 5G | ₹18200 | 2022-05-26 | Buy |
WY-14643 Chemical Properties,Uses,Production
Uses
WY-14643 has been used:
- as a positive control for transfection and luciferase assay
- to stimulate bone marrow–derived macrophages (BMDM) for autophagic flux analysis
- to analyze the regulation of fatty acid metabolism-immune nexus (FAMIN) expression in cell culture
General Description
WY-14643 prevents lipopolysaccharide (LPS)-induced inflammation in synovial fibroblasts. It protects cortical neurons from pro-inflammatory mediator-induced cell injuries. WY-14643 has inhibitory effects on pro-inflammatory responses in microglia. It improves oxido-nitrosative stress in disease models and reduces the generation of reactive oxygen species (ROS), nitric oxide (NO) and lipid peroxidation end-products in the brain.
Biological Activity
Selective PPAR α agonist (EC 50 values are 0.63, 32 and > 100 μ M at PPAR α , PPAR γ and PPAR δ respectively). Negatively inhibits NF- κ B transcriptional activity and decreases the inflammatory response in vitro and in vivo .
Safety Profile
Moderately toxic by ingestion. Suspected carcinogen with experimental carcinogenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl-, NOx and SOx
WY-14643 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 177)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32956 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29810 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32161 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34563 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 22787 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6391 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
50892-23-4(WY-14643)Related Search:
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WY-14643/WY14643
((4-chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)-aceticaci
((4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thio)-aceticaci
4-chloro-6-(2,3-xylidino)-2-*pyrimidinylthioaceti
pirnixicacid
NSC 310038
Acetic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-
wyeth14,643
[4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]-2-PYRIMIDINYL]THIACETIC ACID
(4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]-2-PYRIMIDINYL)THIOACETIC ACID
[4-CHLORO-6-(2,3-XYLIDINO)-2-PYRIMIDINYLTHIO]ACETIC ACID
PIRINIXIC ACID
WY-14643
Pirinixic
(4-CHLORO-6-(2,3-XYLIDINO)-2-PYRIMIDYL-THIO)ACETICACID
4-CHLORO-6-(2,3-XYLIDINO)-2- PYRIMIDINYLTHIOACETIC
4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid, Pirinixic acid
[[4-Chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl]thio]acetic acid
pirinixic acid (WY 14643)
WY-14643 (Pirinixic Acid)
WY-14643 - CAS 50892-23-4 - Calbiochem
WY14643; PIRINIXIC ACID;WY 14643;WY-14643
CS-737
[4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid >
Chloro Acid
99.0%(LC&
WY-14643 USP/EP/BP
2-((4-Chloro-6-((2,3-dimethylphenyl)amino)pyrimidin-2-yl)thio)acetic acid
WY 14643, PPARalpha agonist
50892-23-4
Gene Regulation and Expression
PPAR and RXR Regulators
BioChemical
Cell Signaling and Neuroscience
Cell Biology
Inhibitors
Intracellular receptor
Inhibitor